The hyperthermic and neurotoxic effects of ‘Ecstasy’ (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype (Q35872606)

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scientific article published on August 1, 1995

Language	Label	Description	Also known as
English	The hyperthermic and neurotoxic effects of ‘Ecstasy’ (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype	scientific article published on August 1, 1995

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scholarly article

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Europe PubMed Central

PMC publication ID

10 August 2017

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The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype (English)

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

The hyperthermic and neurotoxic effects of ‘Ecstasy’ (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype (English)

1 reference

10.1111/J.1476-5381.1995.TB15037.X

https://api.crossref.org/works/10.1111/J.1476-5381.1995.TB15037.X

23 May 2024

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M. I. Colado

1

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J. L. Williams

2

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A. R. Green

3

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1 August 1995

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10 August 2017

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23 May 2024

https://europepmc.org/articles/PMC1908797

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7582557

23 May 2024

https://europepmc.org/articles/PMC1908797?pdf=render

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online access status

content deliverer

Europe PubMed Central

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7582557

23 May 2024

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1476-5381.1995.tb15037.x

1 reference

10.1111/J.1476-5381.1995.TB15037.X

https://api.crossref.org/works/10.1111/J.1476-5381.1995.TB15037.X

23 May 2024

https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1995.tb15037.x

1 reference

10.1111/J.1476-5381.1995.TB15037.X

https://api.crossref.org/works/10.1111/J.1476-5381.1995.TB15037.X

23 May 2024

British Journal of Pharmacology

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10 August 2017

115

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10 August 2017

7

1 reference

Europe PubMed Central

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10 August 2017

1281-1289

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

alpha-Phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia

1 reference

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11 July 2018

Participation of cytochrome P450-2B and -2D isozymes in the demethylenation of methylenedioxymethamphetamine enantiomers by rats

1 reference

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5‐HT loss in rat brain following 3, 4‐methylenedioxymethamphetamine (MDMA), p‐chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine

1 reference

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11 July 2018

A study of the mechanism of MDMA ('ecstasy')-induced neurotoxicity of 5-HT neurones using chlormethiazole, dizocilpine and other protective compounds

1 reference

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Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals

1 reference

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Incidence of recreational use of 3,4-methylenedimethoxymethamphetamine (MDMA, "ecstasy") on an undergraduate campus

1 reference

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11 July 2018

Stereochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain

1 reference

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11 July 2018

The effect of MDMA ("Ecstasy") and its optical isomers on schedule-controlled responding in mice.

1 reference

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11 July 2018

Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain

1 reference

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11 July 2018

Effects of the enantiomers of MDA, MDMA and related analogues on [3H]serotonin and [3H]dopamine release from superfused rat brain slices

1 reference

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11 July 2018

The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain

1 reference

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11 July 2018

The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats

1 reference

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11 July 2018

The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man.

1 reference

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11 July 2018

Behavioral and neurochemical effects of orally administered MDMA in the rodent and nonhuman primate.

1 reference

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11 July 2018

The effect of optical isomers of 3,4-methylenedioxymethamphetamine (MDMA) on stereotyped behavior in rats

1 reference

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11 July 2018

Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity.

1 reference

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11 July 2018

(+/-)3,4-Methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates

1 reference

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11 July 2018

3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites

1 reference

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11 July 2018

Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine

1 reference

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11 July 2018

Stereochemical differences in the metabolism of 3,4-methylenedioxymethamphetamine in vivo and in vitro: a pharmacokinetic analysis

1 reference

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11 July 2018

Methylenedioxymethamphetamine-induced hyperthermia and neurotoxicity are independently mediated by 5-HT2 receptors

1 reference

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11 July 2018

MDMA: historical perspectives

1 reference

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11 July 2018

Metabolism of methylenedioxymethamphetamine: formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct.

1 reference

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11 July 2018

3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine

1 reference

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Quinine is a more potent inhibitor than quinidine in rat of the oxidative metabolic routes of methoxyphenamine which involve debrisoquine 4-hydroxylase

1 reference

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Effect of 3,4-methylenedioxymethamphetamine on [3H]paroxetine binding in the frontal cortex and blood platelets of rats

1 reference

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Alterations in hippocampal function following repeated exposure to the amphetamine derivative methylenedioxymethamphetamine ("Ecstasy").

1 reference

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11 July 2018

Molecular genetics of the debrisoquin-sparteine polymorphism

1 reference

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Determination of the mechanism of demethylenation of (methylenedioxy)phenyl compounds by cytochrome P450 using deuterium isotope effects

1 reference

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Protection against oxidative damage to CNS by α-phenyl-tert-butyl nitrone (PBN) and other spin-trapping agents: A novel series of nonlipid free radical scavengers

1 reference

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Regiochemical differences in cytochrome P450 isozymes responsible for the oxidation of methylenedioxyphenyl groups by rabbit liver

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Serotonin 5-HT1-like receptors mediate hyperactivity in rats induced by 3,4-methylenedioxymethamphetamine

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Enzymatic and chemical demethylenation of (methylenedioxy)amphetamine and (methylenedioxy)methamphetamine by rat brain microsomes

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Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")

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Effects of 3,4-dihydroxymethamphetamine and 2,4,5-trihydroxymethamphetamine, two metabolites of 3,4-methylenedioxymethamphetamine, on central serotonergic and dopaminergic systems

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Lack of serotonin neurotoxicity after intraraphe microinjection of (+)-3,4-methylenedioxymethamphetamine (MDMA)

1 reference

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Role of dopamine autoxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced parkinsonism.

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Methylenedioxyamphetamine: neurotoxic effects on serotonergic projections to brainstem nuclei in the rat

1 reference

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Methylenedioxymethamphetamine: a potentially neurotoxic amphetamine analogue

1 reference

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Ecstasy, 3–4 Methylenedioxymethamphetamine (MDMA), a Fatality Associated with Coagulopathy and Hyperthermia

1 reference

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Ion trap tandem mass spectrometric evidence for the metabolism of 3,4-(methylenedioxy)methamphetamine to the potent neurotoxins 2,4,5-trihydroxymethamphetamine and 2,4,5-trihydroxyamphetamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/7582557

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based on heuristic

inferred from PubMed ID database lookup

Multiple severe complications from recreational ingestion of MDMA ('Ecstasy')

1 reference

https://pubmed.ncbi.nlm.nih.gov/7582557

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/7582557

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of non-human primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/7582557

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydroxylation of debrisoquine using perfused liver isolated from Sprague Dawley and DA rats: comparison with in-vivo results

1 reference

https://pubmed.ncbi.nlm.nih.gov/7582557

12 December 2020

based on heuristic

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3,4-Methylenedioxymethamphetamine ("ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/7582557

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct morphologic classes of serotonergic axons in primates exhibit differential vulnerability to the psychotropic drug 3,4-methylenedioxymethamphetamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/7582557

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute and subchronic effects of methylenedioxymethamphetamine [(+/-)MDMA] on locomotion and serotonin syndrome behavior in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/7582557

12 December 2020

based on heuristic

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Reserpine does not prevent 3,4-methylenedioxymethamphetamine-induced neurotoxicity in the rat

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of inducers and inhibitors on the metabolism in vitro and neurochemical effects in vivo of MDMA

1 reference

https://pubmed.ncbi.nlm.nih.gov/7582557

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6)

1 reference

https://pubmed.ncbi.nlm.nih.gov/7582557

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An evaluation of cytochrome P450 isoform activities in the female dark agouti (DA) rat: relevance to its use as a model of the CYP2D6 poor metaboliser phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/7582557

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Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse

1 reference

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12 December 2020

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Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/7582557

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/7582557

12 December 2020

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inferred from PubMed ID database lookup

Animal modelling of human polymorphic drug oxidation—the metabolism of debrisoquine and phenacetin in rat inbred strains

1 reference

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12 December 2020

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Purification and characterization of the rat liver microsomal cytochrome P-450 involved in the 4-hydroxylation of debrisoquine, a prototype for genetic variation in oxidative drug metabolism

1 reference

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Bufuralol 1'-hydroxylase activity of the rat. Strain differences and the effects of inhibitors

1 reference

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'Eve' and 'Ecstasy'. A report of five deaths associated with the use of MDEA and MDMA

1 reference

https://pubmed.ncbi.nlm.nih.gov/7582557

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/7582557

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The spin trap reagent alpha-phenyl-N-tert-butyl nitrone prevents 'ecstasy'-induced neurodegeneration of 5-hydroxytryptamine neurones

13

1 reference

10.1111/J.1476-5381.1995.TB15037.X

https://api.crossref.org/works/10.1111/J.1476-5381.1995.TB15037.X

23 May 2024

Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy").

24

1 reference

10.1111/J.1476-5381.1995.TB15037.X

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Neurotoxicity of MDMA and related compounds: anatomic studies

43

1 reference

10.1111/J.1476-5381.1995.TB15037.X

https://api.crossref.org/works/10.1111/J.1476-5381.1995.TB15037.X

23 May 2024

Identifiers

10.1111/J.1476-5381.1995.TB15037.X

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

ResearchGate publication ID

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