Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity. (Q35875403)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049070%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity (English)

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15 January 2020

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3

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15 January 2020

author name string

Sarah Navina

1

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15 January 2020

Chathur Acharya

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15 January 2020

Lidiya S Orlichenko

4

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15 January 2020

Catherine J Baty

5

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15 January 2020

Sruti S Shiva

6

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15 January 2020

Chandra Durgampudi

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Jenny M Karlsson

8

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15 January 2020

Kenneth Lee

9

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15 January 2020

Kyongtae T Bae

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15 January 2020

Alessandro Furlan

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15 January 2020

Jaideep Behari

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15 January 2020

Shiguang Liu

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15 January 2020

Teresa McHale

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15 January 2020

Larry Nichols

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15 January 2020

Georgios Ioannis Papachristou

16

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15 January 2020

Dhiraj Yadav

17

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15 January 2020

Vijay P Singh

18

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English

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publication date

1 November 2011

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Science Translational Medicine

15 January 2020

published in

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volume

3

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15 January 2020

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107ra110

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issue

107

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A diversity of SERCA Ca2+ pump inhibitors

15 January 2020

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice

11 July 2018

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11 July 2018

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11 July 2018

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Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes

11 July 2018

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Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

11 July 2018

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11 July 2018

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Alcohol redirects CCK-mediated apical exocytosis to the acinar basolateral membrane in alcoholic pancreatitis

11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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Supramaximal cholecystokinin displaces Munc18c from the pancreatic acinar basal surface, redirecting apical exocytosis to the basal membrane

11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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Neutrophil apoptosis during the development and resolution of oleic acid-induced acute lung injury in the rat.

11 July 2018

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11 July 2018

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Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

11 July 2018

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Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships

11 July 2018

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11 July 2018

Postburn pancreatitis

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Influence of trypsin on lipolysis in human fat cells. Comparison with rat adipocytes

11 July 2018

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Demonstration of phosphates in calcium deposits: a modification of von Kossa's reaction

11 July 2018

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Studies on subcutaneous fat necrosis of the newborn

11 July 2018

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Severe acute pancreatitis requiring drainage therapy: findings on computed tomography as predictor of patient outcome.

11 July 2018

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Expression changes of angiotensin II pathways and bioactive mediators during human preadipocytes-visceral differentiation.

24 September 2018

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The role of free fatty acids, pancreatic lipase and Ca+ signalling in injury of isolated acinar cells and pancreatitis model in lipoprotein lipase-deficient mice

24 September 2018

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Enhanced susceptibility to pancreatitis in severe hypertriglyceridaemic lipoprotein lipase-deficient mice and agonist-like function of pancreatic lipase in pancreatic cells.

24 September 2018

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Determination of lipolysis in isolated primary adipocytes

24 September 2018

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Combination of recombinant human growth hormone and propranolol decreases hypermetabolism and inflammation in severely burned children

24 September 2018

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Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition

24 September 2018

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Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice.

24 September 2018

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Clinical significance of increased lipase levels on admission to the ICU.

24 September 2018

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Obesity is an independent risk factor of mortality in severely injured blunt trauma patients.

24 September 2018

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Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity

24 September 2018

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Insulin treatment improves the systemic inflammatory reaction to severe trauma

24 September 2018

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Functioning acinar cell carcinoma of the pancreas

24 September 2018

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Degree of in vivo inhibition of human gastric and pancreatic lipases by Orlistat (Tetrahydrolipstatin, THL) in the stomach and small intestine

24 September 2018

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Serum free fatty acid concentration in patients with acute pancreatitis

24 September 2018

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Change in saturated fat intake is associated with progression of carotid and femoral intima-media thickness, and with levels of soluble intercellular adhesion molecule-1.

24 September 2018

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Serine protease inhibitor causes F-actin redistribution and inhibition of calcium-mediated secretion in pancreatic acini

24 September 2018

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Analysis of the toxic effects of linoleic acid, 12,13-cis-epoxyoctadecenoic acid, and 12,13-dihydroxyoctadecenoic acid in rabbit renal cortical mitochondria

24 September 2018

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Palmitate-induced apoptosis can occur through a ceramide-independent pathway

24 September 2018

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Water immersion stress prevents caerulein-induced pancreatic acinar cell nf-kappa b activation by attenuating caerulein-induced intracellular Ca2+ changes

24 September 2018

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Effect of cerulein hyperstimulation on the paracellular barrier of rat exocrine pancreas.

24 September 2018

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Behavior of serum interleukin 12 in human acute pancreatitis

24 September 2018

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Obesity increases the severity of acute pancreatitis: performance of APACHE-O score and correlation with the inflammatory response

22 October 2018

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12 December 2020

Intracellular transport of pancreatic zymogens during caerulein supramaximal stimulation

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12 December 2020

Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis

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12 December 2020

Admission resistin levels predict peripancreatic necrosis and clinical severity in acute pancreatitis.

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12 December 2020

Body Mass Index (BMI) and mortality in patients with severe burns: is there a "tilt point" at which obesity influences outcome?

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12 December 2020

Obesity increases risk of organ failure after severe trauma

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12 December 2020

New properties of the soybean trypsin inhibitor: Inhibition of human neutrophil elastase and its effect on acute pulmonary injury

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12 December 2020

Free fatty acids in serum of patients with acute necrotizing or edematous pancreatitis

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12 December 2020

Intraperitoneal free fatty acids induce severe hypocalcemia in rats: a model for the hypocalcemia of pancreatitis

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12 December 2020

Urinary free fatty acids bound to albumin aggravate tubulointerstitial damage

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12 December 2020

Serum Profiles of Interleukin-18 in Different Severity Forms of Human Acute Pancreatitis

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12 December 2020

Methods for measuring abdominal obesity in the prediction of severe acute pancreatitis, and their correlation with abdominal fat areas assessed by computed tomography

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12 December 2020

Clinical relevance of caspase-1 activated cytokines in acute pancreatitis: high correlation of serum interleukin-18 with pancreatic necrosis and systemic complications

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12 December 2020

Human acute pancreatitis: its pathogenesis in the light of immunocytochemical and ultrastructural findings in acinar cells

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12 December 2020

Low mortality and high morbidity in severe acute pancreatitis without organ failure: a case for revising the Atlanta classification to include "moderately severe acute pancreatitis"

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12 December 2020

Mode of action of tetrahydrolipstatin: a derivative of the naturally occurring lipase inhibitor lipstatin

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12 December 2020

Renal excretion of free fatty acids

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12 December 2020

Significant elevation of serum interleukin-18 levels in patients with acute pancreatitis

1 reference

12 December 2020

Pancreatic steatosis: harbinger of type 2 diabetes in obese rodents

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12 December 2020

Leukotoxin, a linoleate epoxide: its implication in the late death of patients with extensive burns

1 reference

12 December 2020

Obesity as a predictor of severity in acute pancreatitis

1 reference

12 December 2020

Simultaneous measurement of the rates of appearance of palmitic and linoleic acid in critically ill infants

1 reference

12 December 2020

Tubular complexes in cerulein- and oleic acid-induced pancreatitis in rats: glycoconjugate pattern, immunocytochemical, and ultrastructural findings

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12 December 2020

Albumin-bound fatty acids induce mitochondrial oxidant stress and impair antioxidant responses in proximal tubular cells

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12 December 2020

10.1126/SCITRANSLMED.3002573

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049070%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049070%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference