Dual targeting of therapeutics to endothelial cells: collaborative enhancement of delivery and effect (Q35878956)

10 August 2017

Dual targeting of therapeutics to endothelial cells: collaborative enhancement of delivery and effect (English)

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10 August 2017

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Colin F Greineder

1

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author name string

Jacob B Brenza

2

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10 August 2017

Ronald Carnemolla

3

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10 August 2017

Sergei Zaitsev

4

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10 August 2017

Elizabeth D Hood

5

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10 August 2017

Daniel C Pan

6

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10 August 2017

Bi-Sen Ding

7

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10 August 2017

Charles T Esmon

8

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10 August 2017

Ann Marie Chacko

9

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10 August 2017

Vladimir R Muzykantov

10

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10 August 2017

language of work or name

English

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publication date

7 May 2015

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10 August 2017

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10 August 2017

29

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10 August 2017

8

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10 August 2017

3483-3492

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Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Advanced drug delivery systems for antithrombotic agents.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Bio-inspired liposomal thrombomodulin conjugate through bio-orthogonal chemistry.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Quantitative analysis of thrombomodulin-mediated conversion of protein C to APC: translation from in vitro to in vivo.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Collaborative enhancement of antibody binding to distinct PECAM-1 epitopes modulates endothelial targeting

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Drug carriers for vascular drug delivery

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

The thrombomodulin analog Solulin promotes reperfusion and reduces infarct volume in a thrombotic stroke model

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Delivery of siRNA therapeutics: barriers and carriers

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Targeting antioxidant and antithrombotic biotherapeutics to endothelium

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

The endothelium in acute lung injury/acute respiratory distress syndrome

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Recent approaches to intracellular delivery of drugs and DNA and organelle targeting

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Biomedical aspects of targeted delivery of drugs to pulmonary endothelium

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Targeting of antioxidant and anti-thrombotic drugs to endothelial cell adhesion molecules

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Vascular targeting agents as cancer therapeutics

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

The dawning era of polymer therapeutics

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Studies of a novel human thrombomodulin immobilized substrate: surface characterization and anticoagulation activity evaluation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

The normal role of Activated Protein C in maintaining homeostasis and its relevance to critical illness

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Efficacy and safety of recombinant human activated protein C for severe sepsis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Metalloproteolytic release of endothelial cell protein C receptor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

11 July 2018

The biology of PECAM-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Thrombomodulin release in baboon sepsis: its dependence on the dose of Escherichia coli and the presence of tumor necrosis factor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

The roles of protein C and thrombomodulin in the regulation of blood coagulation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Recombinant human activated protein C as a therapy for severe sepsis: lessons learned?

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Catalytic efficiency of a thrombomodulin-functionalized membrane-mimetic film in a flow model.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Dose-response study of recombinant human soluble thrombomodulin (ART-123) in the prevention of venous thromboembolism after total hip replacement.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Covalently immobilized thrombomodulin inhibits coagulation and complement activation of artificial surfaces in vitro

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Dysfunction of Endothelial Protein C Activation in Severe Meningococcal Sepsis

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4511192

Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial

14 November 2018

1 reference

12 December 2020

Sequential co-immobilization of thrombomodulin and endothelial protein C receptor on polyurethane: activation of protein C

1 reference

12 December 2020

Contributions of the extracellular and cytoplasmic domains of platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) in regulating cell-cell localization

1 reference

12 December 2020

Intravenous recombinant soluble human thrombomodulin prevents venous thrombosis in a rat model

1 reference

12 December 2020

Isolation of IgG antibody Fv-DNA from various mouse and rat hybridoma cell lines using the polymerase chain reaction with a simple set of primers

1 reference

12 December 2020

Immobilization of human thrombomodulin onto poly(ether urethane urea) for developing antithrombogenic blood-contacting materials

1 reference

12 December 2020

Release of thrombomodulin from endothelial cells by concerted action of TNF-alpha and neutrophils: in vivo and in vitro studies

1 reference

12 December 2020

Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes

1 reference

12 December 2020

The endothelial protein C receptor impairs the antibacterial response in murine pneumococcal pneumonia and sepsis

1 reference

12 December 2020

Identifiers

DOI

10.1096/FJ.15-271213

1 reference

release_53jqc5as6bcw3ft4nfl4mudao4

10 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/53jqc5as6bcw3ft4nfl4mudao4

24 November 2022

mapped directly with Wikidata item

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10 August 2017

1 reference