Single periocular injection of celecoxib-PLGA microparticles inhibits diabetes-induced elevations in retinal PGE2, VEGF, and vascular leakage. (Q35885116)

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scientific article published in March 2006

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English	Single periocular injection of celecoxib-PLGA microparticles inhibits diabetes-induced elevations in retinal PGE2, VEGF, and vascular leakage.	scientific article published in March 2006

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17 January 2020

Single periocular injection of celecoxib-PLGA microparticles inhibits diabetes-induced elevations in retinal PGE2, VEGF, and vascular leakage (English)

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17 January 2020

Surya P Ayalasomayajula

2

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17 January 2020

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Aniruddha C Amrite

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17 January 2020

Narayan P S Cheruvu

3

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17 January 2020

Uday B Kompella

4

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17 January 2020

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1 March 2006

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17 January 2020

Investigative Ophthalmology Visual Science

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17 January 2020

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17 January 2020

1149-1160

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17 January 2020

3

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17 January 2020

Size-dependent disposition of nanoparticles and microparticles following subconjunctival administration.

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11 July 2018

Periocular routes for retinal drug delivery

1 reference

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11 July 2018

Pharmacological profile of celecoxib, a specific cyclooxygenase-2 inhibitor

1 reference

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Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy

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Interaction between NO and COX pathways in retinal cells exposed to elevated glucose and retina of diabetic rats

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COX-2 inhibition and colorectal cancer

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Beta-cyclodextrin complexes of celecoxib: molecular-modeling, characterization, and dissolution studies.

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Simvastatin inhibits leukocyte accumulation and vascular permeability in the retinas of rats with streptozotocin-induced diabetes

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Periocular Injection of Microspheres Containing PKC412 Inhibits Choroidal Neovascularization in a Porcine Model

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11 July 2018

Subconjunctival nano- and microparticles sustain retinal delivery of budesonide, a corticosteroid capable of inhibiting VEGF expression

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Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line

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Induction of vascular endothelial growth factor by 4-hydroxynonenal and its prevention by glutathione precursors in retinal pigment epithelial cells

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Regulation by PGE2 of the production of interleukin-6, macrophage colony stimulating factor, and vascular endothelial growth factor in human synovial fibroblasts

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A biodegradable injectable implant sustains systemic and ocular delivery of an aldose reductase inhibitor and ameliorates biochemical changes in a galactose-fed rat model for diabetic complications

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Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression

1 reference

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COX-2 inhibitors and the cardiovascular system

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UV radiation and prostaglandin E2 up-regulate vascular endothelial growth factor (VEGF) in cultured human fibroblasts

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Pharmacological inhibition of diabetic retinopathy: aminoguanidine and aspirin

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Effect of cyclosporin-A on the blood--retinal barrier permeability in streptozotocin-induced diabetes.

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Prostaglandin E2 and vasoactive intestinal peptide increase vascular endothelial cell growth factor mRNAs in lung cancer cells

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Leukocyte-mediated endothelial cell injury and death in the diabetic retina

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Pathogenetic potential of leukocytes in diabetic retinopathy

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Upregulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat.

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11 July 2018

Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy

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Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization

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Histopathology of diabetic retinopathy in man.

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Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders

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Diabetic macular edema. A review

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The correlation between excessive vitreal protein levels, prostaglandin E2 levels, and the blood retinal barrier

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Physical stability and solubility advantage from amorphous celecoxib: the role of thermodynamic quantities and molecular mobility

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24 September 2018

Subconjunctivally administered celecoxib-PLGA microparticles sustain retinal drug levels and alleviate diabetes-induced oxidative stress in a rat model

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Retinal delivery of celecoxib is several-fold higher following subconjunctival administration compared to systemic administration

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Persistent secretion of vascular endothelial growth factor into the vitreous cavity in proliferative diabetic retinopathy after vitrectomy

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Blood-retinal barrier breakdown induced by activation of protein kinase C via vascular endothelial growth factor in streptozotocin-induced diabetic rats

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VEGF164Is Proinflammatory in the Diabetic Retina

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Inhibition of protein kinase C decreases prostaglandin-induced breakdown of the blood-retinal barrier

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24 September 2018

Celecoxib, a selective cyclooxygenase-2 inhibitor, inhibits retinal vascular endothelial growth factor expression and vascular leakage in a streptozotocin-induced diabetic rat model

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Protein levels in the vitreous of rats with streptozotocin-induced diabetes mellitus.

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The relation between expression of vascular endothelial growth factor and breakdown of the blood-retinal barrier in diabetic rat retinas

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and secretion of vascular permeability factor/vascular endothelial growth factor by human retinal pigment epithelial cells

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https://pubmed.ncbi.nlm.nih.gov/16505053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib in rats

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advanced glycation end products induce blood-retinal barrier dysfunction in normoglycemic rats

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based on heuristic

inferred from PubMed ID database lookup

Hypoxic regulation of vascular endothelial growth factor in retinal cells

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1167/IOVS.05-0531

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Europe PubMed Central

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17 January 2020

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Europe PubMed Central

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17 January 2020

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17 January 2020

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