Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease. (Q35903308)

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23 January 2020

title

Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease (English)

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23 January 2020

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3

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23 January 2020

author name string

Manolya Ezgimen

1

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23 January 2020

Huiguo Lai

2

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23 January 2020

Kyungae Lee

4

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23 January 2020

Gregory Cuny

5

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23 January 2020

David A Ostrov

6

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23 January 2020

Radhakrishnan Padmanabhan

7

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publication date

11 February 2012

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23 January 2020

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volume

94

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23 January 2020

issue

1

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23 January 2020

page(s)

18-24

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Serotype-Specific Structural Differences in the Protease-Cofactor Complexes of the Dengue Virus Family

23 January 2020

cites work

1 reference

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Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease

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Identification and Biochemical Characterization of Small-Molecule Inhibitors of West Nile Virus Serine Protease by a High-Throughput Screen

27 July 2018

1 reference

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Pathogenic flaviviruses.

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Structural evidence for regulation and specificity of flaviviral proteases and evolution of theFlaviviridaefold

27 July 2018

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Characterization of the West Nile virus protease substrate specificity and inhibitors.

27 July 2018

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Cleavage preference distinguishes the two-component NS2B–NS3 serine proteinases of Dengue and West Nile viruses

27 July 2018

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Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

27 July 2018

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Recent advances in the molecular biology of west nile virus

27 July 2018

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Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.

27 July 2018

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Transmission cycles, host range, evolution and emergence of arboviral disease

27 July 2018

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Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease

27 July 2018

1 reference

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Molecular biology of flaviviruses

27 July 2018

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Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors.

27 July 2018

1 reference

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Purified NS2B/NS3 serine protease of dengue virus type 2 exhibits cofactor NS2B dependence for cleavage of substrates with dibasic amino acids in vitro

27 July 2018

1 reference

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Cotranslational membrane insertion of the serine proteinase precursor NS2B-NS3(Pro) of dengue virus type 2 is required for efficient in vitro processing and is mediated through the hydrophobic regions of NS2B.

27 July 2018

1 reference

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Dengue 2 virus NS2B and NS3 form a stable complex that can cleave NS3 within the helicase domain

27 July 2018

1 reference

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Mutagenesis of the yellow fever virus NS2B protein: effects on proteolytic processing, NS2B-NS3 complex formation, and viral replication

27 July 2018

1 reference

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Deletion analysis of dengue virus type 4 nonstructural protein NS2B: identification of a domain required for NS2B-NS3 protease activity

27 July 2018

1 reference

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On the size of the active site in proteases. I. Papain

27 July 2018

1 reference

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Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331929

In vitro processing of dengue virus type 2 nonstructural proteins NS2A, NS2B, and NS3

27 July 2018

1 reference

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Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331929

Processing of the yellow fever virus nonstructural polyprotein: a catalytically active NS3 proteinase domain and NS2B are required for cleavages at dibasic sites

27 July 2018

1 reference

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In vitro synthesis of West Nile virus proteins indicates that the amino-terminal segment of the NS3 protein contains the active centre of the protease which cleaves the viral polyprotein after multiple basic amino acids

27 July 2018

1 reference

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Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5

27 July 2018

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The molecular biology of West Nile Virus: a new invader of the western hemisphere

27 July 2018

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Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses

24 September 2018

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10.1016/J.ANTIVIRAL.2012.02.003

24 September 2018

Identifiers

DOI

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23 January 2020

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23 January 2020

PubMed publication ID

22343093

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