Gene transfer vector biodistribution: pivotal safety studies in clinical gene therapy development (Q35904455)

11 August 2017

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title

Gene transfer vector biodistribution: pivotal safety studies in clinical gene therapy development (English)

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11 August 2017

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Gonin P

1

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11 August 2017

Gaillard C

series ordinal

2

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11 August 2017

publication date

1 October 2004

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11 August 2017

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11 August 2017

volume

11 Suppl 1

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11 August 2017

page(s)

S98-S108

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3302378

11 August 2017

exact match

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cites work

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Cirrhotic rat livers with extensive fibrosis can be safely transduced with clinical-grade adenoviral vectors. Evidence of cirrhosis reversion

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Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses

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CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors

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Accurate estimation of transduction efficiency necessitates a multiplex real-time PCR.

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Subcutaneous Administration of a Replication-Competent Adenovirus Expressing HSV-tk to Cotton Rats: Dissemination, Persistence, Shedding, and Pathogenicity

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Plasmid DNA-entrapped nanoparticles engineered from microemulsion precursors: in vitro and in vivo evaluation

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Adenovirus-mediated gene therapy for mucopolysaccharidosis VII: involvement of cross-correction in wide-spread distribution of the gene products and long-term effects of CTLA-4Ig coexpression

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Use of quantitative TaqMan real-time PCR to track the time-dependent distribution of gene transfer vectors in vivo

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21 January 2018

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21 January 2018

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21 January 2018

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Direct intramuscular injection with recombinant AAV vectors results in sustained expression in a dog model of hemophilia

21 January 2018

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21 January 2018

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Cancer Gene Therapy Using Plasmid DNA: Pharmacokinetic Study of DNA Following Injection in Mice

21 January 2018

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Cationic liposome-mediated intravenous gene delivery

21 January 2018

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In vivo disposition characteristics of plasmid DNA complexed with cationic liposomes

21 January 2018

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Systemic gene therapy: biodistribution and long-term expression of a transgene in mice

21 January 2018

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Gene transfer in vivo with DNA-liposome complexes: lack of autoimmunity and gonadal localization

21 January 2018

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Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans

21 January 2018

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Phase I study of direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7, in patients with metastatic melanoma

21 January 2018

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Tissue distribution of liposome-mediated epidermal growth factor receptor antisense gene therapy

21 January 2018

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Plasmid DNA malaria vaccine: tissue distribution and safety studies in mice and rabbits

21 January 2018

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Physiological effects of human growth hormone produced after hydrodynamic gene transfer of a plasmid vector containing the human ubiquitin promotor

21 January 2018

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Development of a novel non-human primate model for preclinical gene vector safety studies. Determining the effects of intracerebral HSV-1 inoculation in the common marmoset: a comparative study

21 January 2018

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Preclinical safety evaluation of G207, a replication-competent herpes simplex virus type 1, inoculated intraprostatically in mice and nonhuman primates

21 January 2018

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Preclinical safety testing of DISC-hGMCSF to support phase I clinical trials in cancer patients

21 January 2018

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Efficient transduction of liver and muscle after in utero injection of lentiviral vectors with different pseudotypes

21 January 2018

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Evaluating the potential of germ line transmission after intravenous administration of recombinant adenovirus in the C3H mouse.

21 January 2018

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Absence of germline infection in male mice following intraventricular injection of adenovirus

21 January 2018

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Potential for germ line transmission after intramyocardial gene delivery by adeno-associated virus

21 January 2018

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Direct exposure of mouse spermatozoa to very high concentrations of a serotype-2 adeno-associated virus gene therapy vector fails to lead to germ cell transduction

21 January 2018

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Aerosol gene delivery in vivo

21 January 2018

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Aerosol-mediated delivery of recombinant adenovirus to the airways of nonhuman primates

21 January 2018

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Tissue distribution of the Ankara strain of vaccinia virus (MVA) after mucosal or systemic administration

21 January 2018

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Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates.

21 January 2018

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Gene therapy. Safer and virus-free?

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302378

Aerosolization of cationic lipid-DNA complexes: lipoplex characterization and optimization of aerosol delivery conditions.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302378

Intraluminal water increases expression of plasmid DNA in rat lung

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302378

Simulated lung transfection by nebulization of liposome cDNA complexes using a cascade impactor seeded with 2-CFSME0-cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302378

Biodistribution of an adenoviral vector carrying the luciferase reporter gene following intravesical or intravenous administration to a mouse

21 January 2018

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7 January 2021

Nasal absorption and biodistribution of plasmid DNA: an alternative route of DNA vaccine delivery

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7 January 2021

Rate of biodistribution of STEALTH liposomes to tumor and skin: influence of liposome diameter and implications for toxicity and therapeutic activity

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7 January 2021

Peptide-Retargeted Adenovirus Encoding a Tissue Inhibitor of Metalloproteinase-1 Decreases Restenosis after Intravascular Gene Transfer

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Intraarticular gene transfer of TNFR:Fc suppresses experimental arthritis with reduced systemic distribution of the gene product

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Physicochemical and pharmacokinetic characteristics of plasmid DNA/cationic liposome complexes

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7 January 2021

Gene Transfer In Vivo with DNA–Liposome Complexes: Safety and Acute Toxicity in Mice

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7 January 2021

Biodistribution and pharmacokinetics of aerosol and intravenously administered DNA-polyethyleneimine complexes: optimization of pulmonary delivery and retention

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Nonclinical toxicology in support of licensure of gene therapies. Arlington, VA, USA, March 13-14, 2003

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Aerosol administration of a recombinant adenovirus expressing CFTR to cystic fibrosis patients: a phase I clinical trial

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Optimization of formulations and conditions for the aerosol delivery of functional cationic lipid:DNA complexes

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7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302378

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11 August 2017

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