Site-saturation mutagenesis of position V117 in OXA-1 β-lactamase: effect of side chain polarity on enzyme carboxylation and substrate turnover (Q35911779)

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scientific article published on 28 March 2012

Language	Label	Description	Also known as
English	Site-saturation mutagenesis of position V117 in OXA-1 β-lactamase: effect of side chain polarity on enzyme carboxylation and substrate turnover	scientific article published on 28 March 2012

Statements

scholarly article

1 reference

Europe PubMed Central

11 August 2017

Site-saturation mutagenesis of position V117 in OXA-1 β-lactamase: effect of side chain polarity on enzyme carboxylation and substrate turnover (English)

1 reference

Europe PubMed Central

11 August 2017

author name string

Jennifer S Buchman

1

1 reference

Europe PubMed Central

11 August 2017

Kyle D Schneider

2

1 reference

Europe PubMed Central

11 August 2017

Aaron R Lloyd

3

1 reference

Europe PubMed Central

11 August 2017

Stephanie L Pavlish

4

1 reference

Europe PubMed Central

11 August 2017

David A Leonard

5

1 reference

Europe PubMed Central

11 August 2017

language of work or name

0 references

publication date

28 March 2012

1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

51

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Europe PubMed Central

11 August 2017

14

1 reference

Europe PubMed Central

11 August 2017

3143-3150

1 reference

Europe PubMed Central

11 August 2017

An Amino Acid Position at Crossroads of Evolution of Protein Function: ANTIBIOTIC SENSOR DOMAIN OF BlaR1 PROTEIN FROM STAPHYLOCOCCUS AUREUS VERSUS CLASS D -LACTAMASES

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336100

27 July 2018

Lysine N -Decarboxylation Switch and Activation of the -Lactam Sensor Domain of BlaR1 Protein of Methicillin-resistant Staphylococcus aureus

1 reference

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Structures of the Class D Carbapenemase OXA-24 from Acinetobacter baumannii in Complex with Doripenem

1 reference

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Three factors that modulate the activity of class D β-lactamases and interfere with the post-translational carboxylation of Lys70

1 reference

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Critical role of tryptophan 154 for the activity and stability of class D beta-lactamases

1 reference

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Diversity, epidemiology, and genetics of class D beta-lactamases

1 reference

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27 July 2018

Mutation of the active site carboxy-lysine (K70) of OXA-1 beta-lactamase results in a deacylation-deficient enzyme

1 reference

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The role of OXA-1 beta-lactamase Asp(66) in the stabilization of the active-site carbamate group and in substrate turnover

1 reference

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Saturation mutagenesis of Asn152 reveals a substrate selectivity switch in P99 cephalosporinase

1 reference

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Crystal structure of the sensor domain of the BlaR penicillin receptor from Bacillus licheniformis

1 reference

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Structural basis for imipenem inhibition of class C beta-lactamases

1 reference

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BOCILLIN FL, a sensitive and commercially available reagent for detection of penicillin-binding proteins

1 reference

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Kinship and diversification of bacterial penicillin-binding proteins and beta-lactamases

1 reference

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A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

1 reference

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Calculation of protein extinction coefficients from amino acid sequence data

1 reference

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Identification of BlaR, the signal transducer for beta-lactamase production in Bacillus licheniformis, as a penicillin-binding protein with strong homology to the OXA-2 beta-lactamase (class D) of Salmonella typhimurium.

1 reference

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A standard numbering scheme for the class A beta-lactamases

1 reference

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Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution

1 reference

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27 July 2018

The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem

1 reference

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24 September 2018

Characterization of the beta-lactam antibiotic sensor domain of the MecR1 signal sensor/transducer protein from methicillin-resistant Staphylococcus aureus.

1 reference

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Discrete steps in sensing of beta-lactam antibiotics by the BlaR1 protein of the methicillin-resistant Staphylococcus aureus bacterium

1 reference

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24 September 2018

OXA-type carbapenemases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336100

24 September 2018

Bacterial resistance to beta-lactam antibiotics: compelling opportunism, compelling opportunity

1 reference

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X-ray crystal structure of the acylated beta-lactam sensor domain of BlaR1 from Staphylococcus aureus and the mechanism of receptor activation for signal transduction

1 reference

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Crystal structures of the Apo and penicillin-acylated forms of the BlaR1 beta-lactam sensor of Staphylococcus aureus

1 reference

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Resistance to beta-lactam antibiotics and its mediation by the sensor domain of the transmembrane BlaR signaling pathway in Staphylococcus aureus

1 reference

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Unexpected advanced generation cephalosporinase activity of the M69F variant of SHV beta-lactamase

1 reference

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Structural milestones in the reaction pathway of an amide hydrolase: substrate, acyl, and product complexes of cephalothin with AmpC beta-lactamase

1 reference

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Critical involvement of a carbamylated lysine in catalytic function of class D -lactamases

1 reference

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Crystal structures of the class D beta-lactamase OXA-13 in the native form and in complex with meropenem

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A proteolytic transmembrane signaling pathway and resistance to beta-lactams in staphylococci

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Lysine N(zeta)-decarboxylation in the BlaR1 protein from Staphylococcus aureus at the root of its function as an antibiotic sensor

1 reference

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12 December 2020

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Identifiers

10.1021/BI201896K

1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

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