Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8(+) T cells and activating Foxp3(+) regulatory T cells. (Q35913679)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22523067%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8(+) T cells and activating Foxp3(+) regulatory T cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22523067%20AND%20SRC:MED&resulttype=core&format=json

2,4-dinitro-1-thiocyanobenzene

29 January 2020

main subject

1 reference

allergic contact dermatitis

ChEBI release 2020-05-28

ChEBI ID

53051

1 reference

7

1 reference

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29 January 2020

Mercedes Gómez de Agüero

1

1 reference

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29 January 2020

Marc Vocanson

2

1 reference

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29 January 2020

Adrien Kissenpfennig

6

1 reference

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29 January 2020

author name string

Fériel Hacini-Rachinel

3

1 reference

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29 January 2020

Morgan Taillardet

4

1 reference

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29 January 2020

Tim Sparwasser

5

1 reference

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29 January 2020

Dominique Kaiserlian

8

1 reference

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29 January 2020

Bertrand Dubois

9

1 reference

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29 January 2020

language of work or name

English

0 references

publication date

23 April 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22523067%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Investigation

29 January 2020

published in

1 reference

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29 January 2020

volume

122

1 reference

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29 January 2020

issue

5

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29 January 2020

page(s)

1700-1711

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Langerhans cells are negative regulators of the anti-Leishmania response.

29 January 2020

cites work

1 reference

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Modification and expulsion of keratins by human epidermal keratinocytes upon hapten exposure in vitro

11 July 2018

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Steady state migratory RelB+ langerin+ dermal dendritic cells mediate peripheral induction of antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells

11 July 2018

1 reference

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Acute ablation of Langerhans cells enhances skin immune responses

11 July 2018

1 reference

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Langerhans cells serve as immunoregulatory cells by activating NKT cells.

11 July 2018

1 reference

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Inducible costimulator (ICOS) is a marker for highly suppressive antigen-specific T cells sharing features of TH17/TH1 and regulatory T cells.

11 July 2018

1 reference

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The mandatory role of IL-10-producing and OX40 ligand-expressing mature Langerhans cells in local UVB-induced immunosuppression

11 July 2018

1 reference

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Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells

11 July 2018

1 reference

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CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells

11 July 2018

1 reference

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Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10.

11 July 2018

1 reference

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Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin

11 July 2018

1 reference

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Plasmacytoid dendritic cells mediate oral tolerance

11 July 2018

1 reference

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Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336977

Identification of a novel population of Langerin+ dendritic cells

11 July 2018

1 reference

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Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state

11 July 2018

1 reference

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The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336977

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336977

CD4+ CD25+ regulatory T cells suppress contact hypersensitivity reactions by blocking influx of effector T cells into inflamed tissue

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336977

Impaired Langerhans cell migration in psoriasis

11 July 2018

1 reference

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Immune mechanisms of allergen-specific sublingual immunotherapy

11 July 2018

1 reference

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Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity

11 July 2018

1 reference

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Studies of hypersensitivity to low molecular weight substances. II. Reactions of some allergenic substituted dinitrobenzenes with cysteine or cystine of skin proteins

11 July 2018

1 reference

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Immunoregulation in the tissues by gammadelta T cells

11 July 2018

1 reference

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Langerhans cells renew in the skin throughout life under steady-state conditions

11 July 2018

1 reference

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Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

11 July 2018

1 reference

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Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity.

11 July 2018

1 reference

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Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen

11 July 2018

1 reference

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Peptide-conjugated hapten groups are the major antigenic determinants for trinitrophenyl-specific cytotoxic T cells

11 July 2018

1 reference

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Glucocorticosteroids modify Langerhans cells to produce TGF-β and expand regulatory T cells.

11 July 2018

1 reference

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Compensatory role of Langerhans cells and langerin-positive dermal dendritic cells in the sensitization phase of murine contact hypersensitivity

24 September 2018

1 reference

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Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells

24 September 2018

1 reference

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Sequential role of plasmacytoid dendritic cells and regulatory T cells in oral tolerance

24 September 2018

1 reference

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Tacrolimus and TGF-beta act synergistically on the generation of Langerhans cells

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336977

Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336977

Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336977

Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336977

Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336977

Quality of life of patients with allergic contact dermatitis: an exploratory analysis by gender, ethnicity, age, and occupation.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336977

Human epidermal langerhans cells express the immunoregulatory enzyme indoleamine 2,3-dioxygenase

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336977

Human CD25+ regulatory T cells maintain immune tolerance to nickel in healthy, nonallergic individuals

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336977

Innate CD4+CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336977

Skin inflammation during contact hypersensitivity is mediated by early recruitment of CD8+ T cytotoxic 1 cells inducing keratinocyte apoptosis.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336977

Migratory Dendritic Cells Transfer Antigen to a Lymph Node-Resident Dendritic Cell Population for Efficient CTL Priming

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336977

Epidermal and dermal dendritic cells display differential activation and migratory behavior while sharing the ability to stimulate CD4+ T cell proliferation in vivo

14 November 2018

1 reference

12 December 2020

Skin exposure to weak and moderate contact allergens induces IFNgamma production by lymph node cells of CD4+ T-cell-depleted mice

1 reference

12 December 2020

Epicutaneous Immunotherapy Results in Rapid Allergen Uptake by Dendritic Cells through Intact Skin and Downregulates the Allergen-Specific Response in Sensitized Mice

1 reference

12 December 2020

Allergic contact dermatitis

1 reference

12 December 2020

Langerhans Cells Activate Naive Self-Antigen-Specific CD8 T Cells in the Steady State

1 reference

12 December 2020

Specific Immunologic Tolerance to Dinitrofluorobenzene Following Topical Application of Dinitrothiocyanobenzene: Modulation by Suppressor T Cells

1 reference

12 December 2020

Major histocompatibility complex class I-restricted CD8+ T cells and class II-restricted CD4+ T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene

1 reference

12 December 2020

A re-appraisal of the skin-sensitizing activity of 2,4-dinitrothiocyanobenzene

1 reference

12 December 2020

Entry into afferent lymphatics and maturation in situ of migrating murine cutaneous dendritic cells

1 reference

12 December 2020

CD8+ T cells produce IL-2, which is required for CD(4+)CD25+ T cell regulation of effector CD8+ T cell development for contact hypersensitivity responses

1 reference

12 December 2020

Comparative analysis of nasal and oral mucosa dendritic cells

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI59725

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22523067%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22523067%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22523067%20AND%20SRC:MED&resulttype=core&format=json