PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques (Q35913702)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22523065%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques (English)

1 reference

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29 January 2020

2

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7

Rama Rao Amara

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29 January 2020

5

Gordon J Freeman

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6

Guido Silvestri

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4

Steven E Bosinger

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29 January 2020

author name string

Ravi Dyavar Shetty

series ordinal

1

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29 January 2020

Kehmia Titanji

series ordinal

3

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29 January 2020

language of work or name

English

0 references

publication date

23 April 2012

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Journal of Clinical Investigation

29 January 2020

published in

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29 January 2020

volume

122

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issue

5

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page(s)

1712-1716

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Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

29 January 2020

cites work

1 reference

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Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections

27 July 2018

1 reference

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TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury

27 July 2018

1 reference

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PD-1 blockade in rhesus macaques: impact on chronic infection and prophylactic vaccination

27 July 2018

1 reference

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Enhancing SIV-specific immunity in vivo by PD-1 blockade

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336983

SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336983

Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336983

Restoring function in exhausted CD8 T cells during chronic viral infection

27 July 2018

1 reference

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Contribution of claudin-5 to barrier properties in tight junctions of epithelial cells

27 July 2018

1 reference

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Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque

27 July 2018

1 reference

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Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336983

Persistent microbial translocation and immune activation in HIV-1-infected South Africans receiving combination antiretroviral therapy.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336983

Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336983

Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response

24 September 2018

1 reference

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The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

24 September 2018

1 reference

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Microbial translocation is a cause of systemic immune activation in chronic HIV infection

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336983

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336983

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336983

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336983

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336983

The relationship between simian immunodeficiency virus RNA levels and the mRNA levels of alpha/beta interferons (IFN-alpha/beta) and IFN-alpha/beta-inducible Mx in lymphoid tissues of rhesus macaques during acute and chronic infection

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3336983

Expression of junctional adhesion molecules on the human lymphatic endothelium

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22523065

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI60612

1 reference

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29 January 2020

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29 January 2020

PubMed publication ID

22523065

1 reference