The Farnesoid X Receptor (FXR) as modulator of bile acid metabolism (Q35919255)

11 August 2017

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title

The Farnesoid X Receptor (FXR) as modulator of bile acid metabolism (English)

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11 August 2017

4

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11 August 2017

1

Folkert Kuipers

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author name string

Folkert Kuipers

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1

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11 August 2017

Thierry Claudel

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2

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11 August 2017

Ekkehard Sturm

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3

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11 August 2017

1 December 2004

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Reviews in Endocrine and Metabolic Disorders

11 August 2017

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11 August 2017

5

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11 August 2017

4

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11 August 2017

319-326

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https://scigraph.springernature.com/pub.10.1023/b:remd.0000045103.00467.9a

11 August 2017

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cites work

Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer

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12 December 2020

Farnesoid X Receptor Regulates Bile Acid-Amino Acid Conjugation

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12 December 2020

Cellular localization and up-regulation of multidrug resistance-associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver

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12 December 2020

Nuclear receptor regulation of cholesterol and bile acid metabolism.

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12 December 2020

Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis

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12 December 2020

The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp

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12 December 2020

Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane

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12 December 2020

Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway

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12 December 2020

Identification of a nuclear receptor for bile acids

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12 December 2020

Identification of a nuclear receptor that is activated by farnesol metabolites

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12 December 2020

Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors

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12 December 2020

Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine

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12 December 2020

Molecular mechanisms of cholestasis: causes and consequences of impaired bile formation

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12 December 2020

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

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12 December 2020

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

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12 December 2020

Identification of the bile acid binding proteins in human serum by photoaffinity labeling

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12 December 2020

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

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12 December 2020

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression

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12 December 2020

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

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12 December 2020

Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1

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12 December 2020

Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis

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12 December 2020

12 alpha-hydroxylase activity in human liver and its relation to cholesterol 7 alpha-hydroxylase activity

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12 December 2020

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

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12 December 2020

Structural basis for bile acid binding and activation of the nuclear receptor FXR

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12 December 2020

Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice

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12 December 2020

Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited

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12 December 2020

Identification of gene-selective modulators of the bile acid receptor FXR.

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12 December 2020

Intracellular transport of bile acids

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12 December 2020

Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor

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12 December 2020

Hepatic basolateral sodium-dependent-bile acid transporter expression in two unusual cases of hypercholanemia and in extrahepatic biliary atresia

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12 December 2020

Molecular pathogenesis of cholestasis.

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12 December 2020

Bile acid sulfotransferase I from rat liver sulfates bile acids and 3-hydroxy steroids: purification, N-terminal amino acid sequence, and kinetic properties.

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12 December 2020

The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate

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12 December 2020

Correlation of farnesoid X receptor coactivator recruitment and cholesterol 7alpha-hydroxylase gene repression by bile acids

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12 December 2020

Bile acids: natural ligands for an orphan nuclear receptor

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12 December 2020

Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription

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12 December 2020

6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

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12 December 2020

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

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12 December 2020

Glucuronidation of hyodeoxycholic acid in human liver. Evidence for a selective role of UDP-glucuronosyltransferase 2B4.

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12 December 2020

The enzymes, regulation, and genetics of bile acid synthesis

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12 December 2020

Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7alpha-hydroxylase

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12 December 2020

Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter.

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12 December 2020

Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation

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12 December 2020

The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver

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12 December 2020

Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol

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12 December 2020

Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system

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12 December 2020

Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes

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12 December 2020

Enhanced expression of the human multidrug resistance protein 3 by bile salt in human enterocytes. A transcriptional control of a plausible bile acid transporter

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12 December 2020

FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity

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12 December 2020

Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

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12 December 2020

Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids

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12 December 2020

Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter

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12 December 2020

Alternative splicing of the rat sodium/bile acid transporter changes its cellular localization and transport properties

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12 December 2020

Cytokines tumor necrosis factor and interleukin-6 in experimental biliary obstruction in mice

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12 December 2020

Genes and cholestasis.

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12 December 2020

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

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12 December 2020

Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein

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12 December 2020

The synthesis of taurocholic and glycocholic acids by preparations of human liver. II. An analysis of the stimulating effect of the L fraction.

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12 December 2020

Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression

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12 December 2020

Purification and characterization of cholyl-CoA: taurine N-acetyltransferase from the liver of domestic fowl (Gallus gallus)

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12 December 2020

Identification of a chemical tool for the orphan nuclear receptor FXR.

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12 December 2020

Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver

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12 December 2020

Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases.

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12 December 2020

Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump

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12 December 2020

Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter

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12 December 2020

In situ localization of the hepatocytic Na+/Taurocholate cotransporting polypeptide in rat liver

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12 December 2020

Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis

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12 December 2020

Retinoid X receptor (RXR) agonist-induced antagonism of farnesoid X receptor (FXR) activity due to absence of coactivator recruitment and decreased DNA binding

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12 December 2020

Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4

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12 December 2020

10.1023/B:REMD.0000045103.00467.9A

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Dimensions Publication ID

11 August 2017

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