Human mitochondrial DNA helicase TWINKLE is both an unwinding and annealing helicase (Q35922647)

11 August 2017

Human mitochondrial DNA helicase TWINKLE is both an unwinding and annealing helicase (English)

1 reference

11 August 2017

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Doyel Sen

1

1 reference

11 August 2017

Divya Nandakumar

series ordinal

2

1 reference

11 August 2017

Guo-Qing Tang

series ordinal

3

1 reference

11 August 2017

Smita S Patel

series ordinal

4

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11 August 2017

language of work or name

English

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publication date

1 March 2012

1 reference

Journal of Biological Chemistry

11 August 2017

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11 August 2017

287

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11 August 2017

18

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11 August 2017

14545-14556

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The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Functional roles of the N- and C-terminal regions of the human mitochondrial single-stranded DNA-binding protein

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

The human mitochondrial replication fork in health and disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Dynamic effects of cofactors and DNA on the oligomeric state of human mitochondrial DNA helicase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Eukaryotic DNA replication control: lock and load, then fire

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Clinical and molecular aspects of diseases of mitochondrial DNA instability.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Physiological and biochemical defects in carboxyl-terminal mutants of mitochondrial DNA helicase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Branch migration enzyme as a Brownian ratchet.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Modular architecture of the hexameric human mitochondrial DNA helicase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Base-stacking and base-pairing contributions into thermal stability of the DNA double helix

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Reconstitution of a minimal mtDNA replisome in vitro

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Structure and function of hexameric helicases.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

A ring-opening mechanism for DNA binding in the central channel of the T7 helicase-primase protein

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

DNA binding in the central channel of bacteriophage T7 helicase-primase is a multistep process. Nucleotide hydrolysis is not required

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Interactions of bacteriophage T7 DNA primase/helicase protein with single-stranded and double-stranded DNAs

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

The gene 4 protein of bacteriophage T7. Characterization of helicase activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Cell Envelope and Shape of Escherichia coli K12. Crosslinking with Dimethyl Imidoesters of the Whole Cell Wall

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Large scale purification and biochemical characterization of T7 primase/helicase proteins. Evidence for homodimer and heterodimer formation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Single-stranded DNA binding proteins unwind the newly synthesized double-stranded DNA of model miniforks.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Structure-function defects of the twinkle amino-terminal region in progressive external ophthalmoplegia

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Structure-function defects of the TWINKLE linker region in progressive external ophthalmoplegia.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

The N-terminal domain of TWINKLE contributes to single-stranded DNA binding and DNA helicase activities

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

The accessory subunit B of DNA polymerase gamma is required for mitochondrial replisome function

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3340288

Structural studies of the archaeal MCM complex in different functional states

24 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M111.309468

Nucleotide-dependent binding of the gene 4 protein of bacteriophage T7 to single-stranded DNA

21 January 2018

1 reference

12 December 2020

Bacteriophage T7 DNA helicase binds dTTP, forms hexamers, and binds DNA in the absence of Mg2+. The presence of dTTP is sufficient for hexamer formation and DNA binding

1 reference

12 December 2020

T7 RNA polymerase-induced bending of promoter DNA is coupled to DNA opening

1 reference

12 December 2020

Oligomeric states of bacteriophage T7 gene 4 primase/helicase

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M111.309468

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

22383523

1 reference