A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis. (Q35923499)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26035393%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

title

A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26035393%20AND%20SRC:MED&resulttype=core&format=json

amyotrophic lateral sclerosis

16 February 2020

main subject

0 references

1 reference

4

1 reference

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16 February 2020

Bharath Wootla

6

1 reference

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16 February 2020

Sang-Hyun Oh

11

1 reference

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16 February 2020

Moses Rodriguez

13

1 reference

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16 February 2020

author name string

Xiaohua Xu

1

1 reference

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16 February 2020

Aleksandar Denic

2

1 reference

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16 February 2020

Luke R Jordan

3

1 reference

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16 February 2020

Arthur E Warrington

5

1 reference

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16 February 2020

Louisa M Papke

7

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16 February 2020

Laurie J Zoecklein

8

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16 February 2020

Daehan Yoo

9

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16 February 2020

Jonah Shaver

10

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16 February 2020

Larry R Pease

12

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16 February 2020

language of work or name

1 reference

28 May 2015

1 reference

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Disease Models & Mechanisms

16 February 2020

published in

1 reference

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16 February 2020

volume

8

1 reference

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16 February 2020

issue

8

1 reference

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16 February 2020

page(s)

831-842

1 reference

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Creative Commons Attribution 3.0 Unported

16 February 2020

copyright license

start time

18 May 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4527295/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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2 October 2017

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Myelin-associated glycoprotein and its axonal receptors

2 October 2017

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Naturally occurring auto-antibodies in homeostasis and disease

2 October 2017

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Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS.

2 October 2017

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Anti-amyloid beta protein antibody passage across the blood-brain barrier in the SAMP8 mouse model of Alzheimer's disease: an age-related selective uptake with reversal of learning impairment

2 October 2017

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Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice.

2 October 2017

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A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS.

2 October 2017

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Unraveling the mechanisms involved in motor neuron degeneration in ALS

2 October 2017

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Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration

2 October 2017

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2 October 2017

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Mechanisms of neurodegeneration in amyotrophic lateral sclerosis

2 October 2017

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2 October 2017

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2 October 2017

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Human monoclonal antibodies reactive to oligodendrocytes promote remyelination in a model of multiple sclerosis

2 October 2017

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Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects

2 October 2017

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Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions

2 October 2017

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Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis

2 October 2017

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2 October 2017

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Spinal transection reduces both spinal antinociception and CNS concentration of systemically administered morphine in rats

2 October 2017

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Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism

2 October 2017

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Mobility measurement by analysis of fluorescence photobleaching recovery kinetics

2 October 2017

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The mechanism of action of cholera toxin in pigeon erythrocyte lysates

2 October 2017

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A method improving the accuracy of fluorescence recovery after photobleaching analysis.

2 October 2017

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Clonal evolution in Waldenstrom macroglobulinemia highlights functional role of B-cell receptor

11 July 2018

1 reference

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Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

Direct observation of myelination in vivo in the mature human central nervous system. A model for the behaviour of oligodendrocyte progenitors and their progeny.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

Localization patterns for immunoglobulins and albumins in the brain suggest diverse mechanisms for their transport across the blood-brain barrier (BBB)

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

Rodent models of amyotrophic lateral sclerosis.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

Gangliosides as regulators of cell signaling: ganglioside-protein interactions or ganglioside-driven membrane organization?

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

Exposure levels of anti-LINGO-1 Li81 antibody in the central nervous system and dose-efficacy relationships in rat spinal cord remyelination models after systemic administration.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

Surface plasmon sensor based on the enhanced light transmission through arrays of nanoholes in gold films.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

Binding of soluble myelin-associated glycoprotein to specific gangliosides induces the association of p75NTR to lipid rafts and signal transduction.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

Localized surface plasmon resonance sensing of lipid-membrane-mediated biorecognition events.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

Neuron-binding human monoclonal antibodies support central nervous system neurite extension

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

Lipid rafts mediate the interaction between myelin-associated glycoprotein (MAG) on myelin and MAG-receptors on neurons

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

The adhesion protein TAG-1 has a ganglioside environment in the sphingolipid-enriched membrane domains of neuronal cells in culture

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

Direct evidence that a human antibody derived from patient serum can promote myelin repair in a mouse model of chronic-progressive demyelinating disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

The specificity of monoclonal antibody A2B5 to c-series gangliosides.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

Kinetic analysis of antibody-antigen interactions at a supported lipid monolayer.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

Cholera toxin binding affinity and specificity for gangliosides determined by surface plasmon resonance

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

Binding of soluble myelin-associated glycoprotein to specific gangliosides induces the association of p75NTR to lipid rafts and signal transduction

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4527295

Ultrasmooth Patterned Metals for Plasmonics and Metamaterials

14 November 2018

1 reference

12 December 2020

From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Arthrobacter ureafaciens sialidase isoenzymes, L, M1 and M2, cleave fucosyl GM1

1 reference

12 December 2020

Tubulin Anchoring to Glycolipid-enriched, Detergent-resistant Domains of the Neuronal Plasma Membrane

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12 December 2020

Amyotrophic lateral sclerosis associated with mutations in superoxide dismutase: a putative mechanism of degeneration

1 reference

12 December 2020

The influence of polyvalency on the binding properties of antibodies

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12 December 2020

Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS

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12 December 2020

Time course of neuropathology in the spinal cord of G86R superoxide dismutase transgenic mice

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12 December 2020

Identifiers

DOI

10.1242/DMM.020727

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26035393%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26035393%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

PubMed publication ID

26035393

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26035393%20AND%20SRC:MED&resulttype=core&format=json