Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration (Q35925767)

11 August 2017

Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration (English)

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11 August 2017

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5

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13 June 2020

Andrew B. West

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13 June 2020

author name string

João P L Daher

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13 June 2020

Hisham A Abdelmotilib

2

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13 June 2020

Xianzhen Hu

3

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13 June 2020

Laura A Volpicelli-Daley

4

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13 June 2020

Kyle B Fraser

6

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13 June 2020

Elie Needle

7

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13 June 2020

Yi Chen

8

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13 June 2020

Stefanus J Steyn

9

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13 June 2020

Paul Galatsis

10

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13 June 2020

Warren D Hirst

11

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13 June 2020

language of work or name

English

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publication date

15 June 2015

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Journal of Biological Chemistry

11 August 2017

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13 June 2020

volume

290

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13 June 2020

issue

32

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13 June 2020

page(s)

19433-19444

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describes a project that uses

13 June 2020

ImageJ

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11 June 2022

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based on heuristic

inferred from PubMed Central ID database lookup

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rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration

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Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs

2 October 2017

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Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasis

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High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain

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2 October 2017

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11 July 2018

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11 July 2018

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The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia.

11 July 2018

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11 July 2018

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Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging

24 September 2018

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Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification

24 September 2018

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24 September 2018

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24 September 2018

Identifiers

DOI

10.1074/JBC.M115.660001

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26078453%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26078453%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference