Integration of glycosphingolipid metabolism and cell-fate decisions in cancer and stem cells: review and hypothesis (Q35932889)

11 August 2017

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title

Integration of glycosphingolipid metabolism and cell-fate decisions in cancer and stem cells: review and hypothesis (English)

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11 August 2017

Erhard Bieberich

1

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11 August 2017

publication date

1 January 2004

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11 August 2017

published in

Glycoconjugate Journal

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11 August 2017

volume

21

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11 August 2017

issue

6

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11 August 2017

page(s)

315-327

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Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death.

11 August 2017

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Tumor-Associated Carbohydrate Antigens Defining Tumor Malignancy: Basis for Development of Anti-Cancer Vaccines

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Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line

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Neuroblastic and Schwannian stromal cells of neuroblastoma are derived from a tumoral progenitor cell.

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Sphingolipid Depletion Increases Formation of the Scrapie Prion Protein in Neuroblastoma Cells Infected with Prions

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Synthesis and characterization of novel ceramide analogs for induction of apoptosis in human cancer cells

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Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid.

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THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies

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12 December 2020

Characterization of serine palmitoyltransferase activity in Chinese hamster ovary cells

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12 December 2020

A new cell surface, detergent-insoluble glycoprotein matrix of human and hamster fibroblasts. The role of disulfide bonds in stabilization of the matrix

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12 December 2020

Regulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases

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12 December 2020

Kinase suppressor of Ras is ceramide-activated protein kinase

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12 December 2020

De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway

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12 December 2020

Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter

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Apaf1 is required for mitochondrial pathways of apoptosis and brain development

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A seed for Alzheimer amyloid in the brain.

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Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals

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12 December 2020

Ganglioside function in calcium homeostasis and signaling

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12 December 2020

Ceramide induces cell cycle arrest and upregulates p27kip in nasopharyngeal carcinoma cells

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12 December 2020

Selective ceramide binding to protein kinase C-alpha and -delta isoenzymes in renal mesangial cells

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12 December 2020

Stage-specific embryonic antigens (SSEA-3 and -4) are epitopes of a unique globo-series ganglioside isolated from human teratocarcinoma cells

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12 December 2020

The topoisomerase inhibitors camptothecin and etoposide induce a CD95-independent apoptosis of activated peripheral lymphocytes

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12 December 2020

Phosphorylation of Raf by ceramide-activated protein kinase

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12 December 2020

Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells

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12 December 2020

A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation.

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12 December 2020

De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.

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12 December 2020

Raft ceramide in molecular medicine

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12 December 2020

Ceramide stimulates a cytosolic protein phosphatase

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12 December 2020

Chromatin neutral sphingomyelinase and its role in hepatic regeneration

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12 December 2020

Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism

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12 December 2020

Immunohistochemical localization of murine stage-specific embryonic antigens in human testicular germ cell tumors

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12 December 2020

Hydrophobic interactions of tubulin

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12 December 2020

Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

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12 December 2020

Identification of a common sphingolipid-binding domain in Alzheimer, prion, and HIV-1 proteins.

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12 December 2020

Cancer dormancy: role of cyclin-dependent kinase inhibitors in induction of cell cycle arrest mediated via membrane IgM.

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12 December 2020

Hypothesis: ceramide conditionally activates atypical protein kinases C, Raf-1 and KSR through binding to their cysteine-rich domains

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12 December 2020

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

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12 December 2020

Cell membrane GM1 ganglioside is a functional coreceptor for fibroblast growth factor 2

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12 December 2020

New globoseries glycosphingolipids in human teratocarcinoma reactive with the monoclonal antibody directed to a developmentally regulated antigen, stage-specific embryonic antigen 3

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12 December 2020

GM1 ganglioside inhibits amyloid beta-protein induced-cytokine release

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12 December 2020

Association of cellular prion protein with gangliosides in plasma membrane microdomains of neural and lymphocytic cells

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12 December 2020

Differential requirement for caspase 9 in apoptotic pathways in vivo.

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12 December 2020

Absence of p53-dependent cell cycle regulation in pluripotent mouse cell lines

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12 December 2020

Ganglioside/protein kinase signals triggering cytoskeletal actin reorganization

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12 December 2020

The role of cell death in regulating the size and shape of the mammalian forebrain

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12 December 2020

Contrasting patterns of retinoblastoma protein expression in mouse embryonic stem cells and embryonic fibroblasts

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12 December 2020

Differentiation of human neuroblastoma cells in vitro--morphological changes induced by dibutyrl cyclic AMP

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12 December 2020

Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

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12 December 2020

Characterization of high-affinity binding between gangliosides and amyloid beta-protein

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12 December 2020

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase

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12 December 2020

Lubricating cell signaling pathways with gangliosides

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12 December 2020

Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid

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12 December 2020

Vaccine therapy for small cell lung cancer

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12 December 2020

Regulation of cyclin-dependent kinase 2 activity by ceramide

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12 December 2020

Sphingolipids as receptor modulators. An overview

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12 December 2020

Serine palmitoyltransferase: role in apoptotic de novo ceramide synthesis and other stress responses

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12 December 2020

Surface carbohydrates of hamster fibroblasts. I. Chemical characterization of surface-labeled glycosphingolipids and aspecific ceramide tetrasaccharide for transformants

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12 December 2020

CD95 Signaling via Ceramide-rich Membrane Rafts

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12 December 2020

Ganglioside glycosyltransferases organize in distinct multienzyme complexes in CHO-K1 cells.

1 reference

12 December 2020

Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-kappaB/JNK kinase and cell survival

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12 December 2020

Ceramide-mediated clustering is required for CD95-DISC formation

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12 December 2020

The role of globo-series glycolipids in neuronal cell differentiation--a review

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12 December 2020

Neutral sphingomyelinase: Localization in rat liver nuclei and involvement in regeneration/proliferation

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12 December 2020

Development regulation of ganglioside metabolism

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12 December 2020

Lipid rafts-protein association and the regulation of protein activity

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12 December 2020

De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase

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12 December 2020

Biosynthesis of proteins, nucleic acids and glycosphingolipids by synchronized KB cells

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12 December 2020

P53 mediates ceramide-induced apoptosis in SKN-SH cells

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12 December 2020

Differential effects of glycolipid biosynthesis inhibitors on ceramide-induced cell death in neuroblastoma cells

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12 December 2020

Role for ceramide in cell cycle arrest.

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12 December 2020

Protein-ribosome-mRNA display: affinity isolation of enzyme-ribosome-mRNA complexes and cDNA cloning in a single-tube reaction

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12 December 2020

Size distribution of retrovirally marked lineages matches prediction from population measurements of cell cycle behavior

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12 December 2020

Production of ceramides causes apoptosis during early neural differentiation in vitro

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12 December 2020

Taxol-induced ceramide generation and apoptosis in human breast cancer cells

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12 December 2020

p21 promotes ceramide-induced apoptosis and antagonizes the antideath effect of Bcl-2 in human hepatocarcinoma cells

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12 December 2020

Mouse monoclonal IgG3 antibody detecting GD3 ganglioside: a phase I trial in patients with malignant melanoma

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12 December 2020

Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase

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12 December 2020

Ganglioside modulation of neural cell adhesion molecule and N-cadherin-dependent neurite outgrowth

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12 December 2020

Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis

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12 December 2020

Cerebellar neurons lacking complex gangliosides degenerate in the presence of depolarizing levels of potassium

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12 December 2020

GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

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12 December 2020

Expression of gangliosides in neuronal development of P19 embryonal carcinoma stem cells

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12 December 2020

The growth arrest and downregulation of c-myc transcription induced by ceramide are related events dependent on p21 induction, Rb underphosphorylation and E2F sequestering

1 reference

12 December 2020

Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells.

1 reference

12 December 2020

Regulation of ganglioside biosynthesis in the nervous system

1 reference

12 December 2020

Intermediate filaments and their associates: multi-talented structural elements specifying cytoarchitecture and cytodynamics

1 reference

12 December 2020

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha

1 reference

12 December 2020

Extracellular carbohydrate-signal triggering cAMP-dependent protein kinase-dependent neuronal actin-reorganization

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12 December 2020

Glycosylation defining cancer malignancy: new wine in an old bottle

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12 December 2020

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid

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12 December 2020

Sialidase gene transfection enhances epidermal growth factor receptor activity in an epidermoid carcinoma cell line, A431.

1 reference

12 December 2020

Ceramide in rafts (detergent-insoluble fraction) mediates cell death in neurotumor cell lines

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12 December 2020

1-phenyl-2-decanoylamino-3-morpholino-1-propanol chemosensitizes neuroblastoma cells for taxol and vincristine.

1 reference

12 December 2020

Expression of gangliosides in an immortalized neural progenitor/stem cell line

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12 December 2020

Induction of p53-independent p21 during ceramide-induced G1 arrest in human hepatocarcinoma cells

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12 December 2020

N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells

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12 December 2020

Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide

1 reference

12 December 2020

Identification of a cancer stem cell in human brain tumors

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12 December 2020

Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis

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12 December 2020

Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action

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12 December 2020

Identification of ceramide binding proteins in neuronal cells: a critical point of view.

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12 December 2020

Tubulin Anchoring to Glycolipid-enriched, Detergent-resistant Domains of the Neuronal Plasma Membrane

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12 December 2020

Hydrophobic chromatography of tubulin on immobilized colchicine columns with various spacers

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12 December 2020

Changes in composition of newly synthesized sphingolipids of HeLa cells during the cell cycle -- suppression of sphingomyelin and higher-glycosphingolipid synthesis and accumulation of ceramide and glucosylceramide in mitotic cells

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12 December 2020

Expression and localization of Lewis(x) glycolipids and GD1a ganglioside in human glioma cells

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12 December 2020

The effects of GM1 and bFGF synergistically inducing adult rat bone marrow stromal cells to form neural progenitor cells and their differentiation

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12 December 2020

Glucosylceramide synthase and apoptosis

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12 December 2020

Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3.

1 reference

12 December 2020

Ceramide mimics tumour necrosis factor-alpha in the induction of cell cycle arrest in endothelial cells. Induction of the tumour suppressor p53 with decrease in retinoblastoma/protein levels

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12 December 2020

Cell-cycle-dependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M.

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12 December 2020

The novel second messenger ceramide: identification, mechanism of action, and cellular activity

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12 December 2020

Prion rods contain small amounts of two host sphingolipids as revealed by thin-layer chromatography and mass spectrometry

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12 December 2020

A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1

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12 December 2020

Gangliosides--a new therapeutic agent against stroke and Alzheimer's disease

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12 December 2020

Pluripotency and tumorigenicity.

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12 December 2020

Lipid rafts make for slippery platforms

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12 December 2020

The function of PML in p53-dependent apoptosis

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12 December 2020

Membrane dynamics and cell polarity: the role of sphingolipids

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12 December 2020

Neural stem cells and regulation of cell number

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12 December 2020

Ceramide: second messenger or modulator of membrane structure and dynamics?

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12 December 2020

Identification of two RNA cis-elements that function to regulate the 5' splice site selection of Bcl-x pre-mRNA in response to ceramide

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12 December 2020

Ceramide selectively displaces cholesterol from ordered lipid domains (rafts): implications for lipid raft structure and function

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12 December 2020

Ceramide glycosylation potentiates cellular multidrug resistance

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12 December 2020

Involvement of p27(kip1) in ceramide-mediated apoptosis in HL-60 cells

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12 December 2020

Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line

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12 December 2020

Ceramide-induced apoptosis by translocation, phosphorylation, and activation of protein kinase Cdelta in the Golgi complex

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12 December 2020

Antitumor activity via inhibition of glycosphingolipid biosynthesis.

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12 December 2020

A vital role for glycosphingolipid synthesis during development and differentiation

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12 December 2020

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12 December 2020

Lipid rafts: elusive or illusive?

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12 December 2020

Ganglioside GD2 specific monoclonal antibody 3F8: a phase I study in patients with neuroblastoma and malignant melanoma

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12 December 2020

Cancer stem cells persist in many cancer cell lines

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12 December 2020

Importance of C1B domain for lipid messenger-induced targeting of protein kinase C.

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12 December 2020

Glycolipid core structure switching from globo- to lacto- and ganglio-series during retinoic acid-induced differentiation of TERA-2-derived human embryonal carcinoma cells

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12 December 2020

Enhanced insulin sensitivity in mice lacking ganglioside GM3.

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12 December 2020

Regulation of apoptosis during neuronal differentiation by ceramide and b-series complex gangliosides

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12 December 2020

Regulation of ganglioside biosynthesis in the nervous system

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12 December 2020

10.1023/B:GLYC.0000046274.35732.47

Identifiers

DOI

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Dimensions Publication ID

11 August 2017

1025483702

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