Antibiotic pharmacokinetic and pharmacodynamic considerations in critical illness (Q35944927)

11 August 2017

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title

Antibiotic pharmacokinetic and pharmacodynamic considerations in critical illness (English)

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11 August 2017

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Rina Mehrotra

1

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11 August 2017

Raffaele De Gaudio

series ordinal

2

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11 August 2017

Mark Palazzo

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3

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11 August 2017

language of work or name

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5 November 2004

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11 August 2017

Intensive Care Medicine

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11 August 2017

30

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11 August 2017

12

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11 August 2017

2145-2156

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https://scigraph.springernature.com/pub.10.1007/s00134-004-2428-9

11 August 2017

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cites work

Killing of Pseudomonas aeruginosa during continuous and intermittent infusion of ceftazidime in an in vitro pharmacokinetic model

1 reference

https://api.crossref.org/works/10.1007%2FS00134-004-2428-9

Pharmacokinetics of systemically administered antibiotics in patients with thermal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00134-004-2428-9

Gentamicin Sulfate Pharmacokinetics: Lower Levels of Gentamicin in Blood during Fever

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00134-004-2428-9

A meta-analysis of the relative efficacy and toxicity of single daily dosing versus multiple daily dosing of aminoglycosides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00134-004-2428-9

A meta-analysis of extended-interval dosing versus multiple daily dosing of aminoglycosides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00134-004-2428-9

Single or multiple daily doses of aminoglycosides: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00134-004-2428-9

Risk factors for the development of auditory toxicity in patients receiving aminoglycosides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00134-004-2428-9

Risk Factors for Nephrotoxicity in Patients Treated with Aminoglycosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00134-004-2428-9

Experience with a once-daily aminoglycoside program administered to 2,184 adult patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00134-004-2428-9

Ciprofloxacin-induced, low-level resistance to structurally unrelated antibiotics in Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00134-004-2428-9

Cefotaxime in bronchopulmonary infections--a clinical and pharmacological study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00134-004-2428-9

High-performance liquid chromatography measurement of antimicrobial concentrations in polymorphonuclear leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00134-004-2428-9

Bronchial Secretion Levels of Amikacin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00134-004-2428-9

Amikacin sulfate levels in human serum and bile

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00134-004-2428-9

Intraventricular levels of amikacin after intravenous administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00134-004-2428-9

Ciprofloxacin concentrations in bone and muscle after oral dosing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00134-004-2428-9

Penetration of antibiotics into respiratory secretions.

21 January 2018

1 reference

12 December 2020

Low plasma cefepime levels in critically ill septic patients: pharmacokinetic modeling indicates improved troughs with revised dosing

1 reference

12 December 2020

Continuous infusion versus intermittent administration of ceftazidime in critically ill patients with suspected gram-negative infections

1 reference

12 December 2020

Analysis of 1,186 Episodes of Gram-Negative Bacteremia in Non-University Hospitals: The Effects of Antimicrobial Therapy

1 reference

12 December 2020

A meta-analysis of studies on the safety and efficacy of aminoglycosides given either once daily or as divided doses

1 reference

12 December 2020

Tissue penetration of the new quinolones in humans

1 reference

12 December 2020

Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients

1 reference

12 December 2020

Continuous infusion of vancomycin in post-neurosurgical staphylococcal meningitis in adults

1 reference

12 December 2020

Gram-negative bacteremia. IV. Re-evaluation of clinical features and treatment in 612 patients

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12 December 2020

Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicity

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12 December 2020

Respiratory tract penetration of ciprofloxacin

1 reference

12 December 2020

Ascitic fluid and serum cefotaxime and desacetyl cefotaxime levels in patients treated for bacterial peritonitis

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12 December 2020

[Continuous administration of vancomycin in patients with severe burns]

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12 December 2020

Continuous infusion of vancomycin in methicillin-resistant staphylococcus infection.

1 reference

12 December 2020

Cefotaxime concentration in the bile and wall of the gallbladder

1 reference

12 December 2020

Advancing age and acute infection influence the kinetics of ceftazidime

1 reference

12 December 2020

Effects of method of antibiotic administration on extravascular penetration: cross-over study of cefazolin given by intermittent injection or constant infusion

1 reference

12 December 2020

The rate of bactericidal action of penicillin in vitro as a function of its concentration, and its paradoxically reduced activity at high concentrations against certain organisms

1 reference

12 December 2020

Teicoplanin therapy for Staphylococcus aureus septicaemia: relationship between pre-dose serum concentrations and outcome

1 reference

12 December 2020

[Bronchial diffusion of piperacillin in 18 intensive care patients]

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12 December 2020

An evaluation of optimal sampling strategy and adaptive study design.

1 reference

12 December 2020

The kinetics of cefuroxime in ascitic and pleural fluid

1 reference

12 December 2020

Characterization and quantitation of the pharmacodynamics of fluconazole in a neutropenic murine disseminated candidiasis infection model

1 reference

12 December 2020

Cellular uptake and cell-associated activity of third generation cephalosporins

1 reference

12 December 2020

Cefuroxime versus ampicillin and chloramphenicol for the treatment of bacterial meningitis. Report from a Swedish Study Group

1 reference

12 December 2020

Pharmacodynamic factors of antibiotic efficacy

1 reference

12 December 2020

Vancomycin penetration of uninfected pleural fluid exudate after continuous or intermittent infusion

1 reference

12 December 2020

The importance of pharmacokinetic/pharmacodynamic surrogate markers to outcome. Focus on antibacterial agents

1 reference

12 December 2020

The influence of protein binding upon tissue fluid levels of six beta-lactam antibiotics

1 reference

12 December 2020

Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients

1 reference

12 December 2020

The bactericidal action of penicillin in vivo: the participation of the host, and the slow recovery of the surviving organisms

1 reference

12 December 2020

Conditions for the emergence of resistance to cefpirome and ceftazidime in experimental endocarditis due to Pseudomonas aeruginosa

1 reference

12 December 2020

Kinetics of antimicrobial activity

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12 December 2020

Pharmacodynamic evaluation of factors associated with the development of bacterial resistance in acutely ill patients during therapy

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12 December 2020

Antibiotic concentrations in ascitic fluid of patients with ascites and bacterial peritonitis

1 reference

12 December 2020

In vivo efficacy of continuous infusion versus intermittent dosing of ceftazidime alone or in combination with amikacin relative to human kinetic profiles in a Pseudomonas aeruginosa rabbit endocarditis model

1 reference

12 December 2020

Pharmacodynamic effects of meropenem on gram-negative bacteria.

1 reference

12 December 2020

Biliary pharmacokinetic profile of piperacillin: experimental data and evaluation in man.

1 reference

12 December 2020

The influence of ascites on the pharmacokinetics of amikacin

1 reference

12 December 2020

Cerebrospinal fluid penetration and pharmacokinetics of vancomycin administered by continuous infusion to mechanically ventilated patients in an intensive care unit

1 reference

12 December 2020

A randomized study of carbenicillin plus cefamandole or tobramycin in the treatment of febrile episodes in cancer patients

1 reference

12 December 2020

Failure of a once-daily regimen of cefonicid for treatment of endocarditis due to Staphylococcus aureus.

1 reference

12 December 2020

In vitro pharmacodynamics of ceftazidime against Pseudomonas aeruginosa isolates from cystic fibrosis patients

1 reference

12 December 2020

Killing and regrowth of bacteria in vitro: a review.

1 reference

12 December 2020

Establishing MIC breakpoints and the interpretation of in vitro susceptibility tests.

1 reference

12 December 2020

Postantibiotic effect in Pseudomonas aeruginosa following single and multiple aminoglycoside exposures in vitro

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12 December 2020

Gentamicin volume of distribution in critically ill septic patients

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12 December 2020

Effect of protein binding on antibiotic activity in vivo

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12 December 2020

The in-vivo postantibiotic effect of imipenem and other new antimicrobials

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12 December 2020

Continuous infusion versus intermittent administration of meropenem in critically ill patients

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12 December 2020

Post-antibiotic effect of three quinolones against gram negative isolates from urine.

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12 December 2020

High teicoplanin uptake by human neutrophils

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12 December 2020

In-vivo assessment of in-vitro killing patterns of Pseudomonas aeruginosa

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12 December 2020

The Value of Routine Microbial Investigation in Ventilator-Associated Pneumonia

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12 December 2020

Impact of the antibiotic dosage schedule on efficacy in experimental lung infections.

1 reference

12 December 2020

Role of serum protein binding and multiple antibiotic doses in the extravascular distribution of ceftizoxime and cefotaxime

1 reference

12 December 2020

Continuous versus intermittent administration of ceftazidime in intensive care unit patients with nosocomial pneumonia

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12 December 2020

Continuous infusion of beta-lactam antibiotics

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12 December 2020

Outer membrane proteins profiles of Pseudomonas aeruginosa after the post-antibiotic effect of imipenem

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12 December 2020

Effects of treatment and the metabolic response to injury on drug clearance: a prospective study with piperacillin.

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12 December 2020

Predictive value of susceptibility tests for the outcome of antibacterial therapy

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12 December 2020

Intermittent bolus dosing of ceftazidime in critically ill patients.

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12 December 2020

Concentration of amoxycillin and clavulanate in lung compartments in adults without pulmonary infection

1 reference

12 December 2020

Altered pharmacokinetics of ceftazidime in critically ill patients

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12 December 2020

Outcomes analysis of delayed antibiotic treatment for hospital-acquired Staphylococcus aureus bacteremia

1 reference

12 December 2020

Penetration of vancomycin into human lung tissue

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12 December 2020

The post-antimicrobial suppressive effect of quinolone agents.

1 reference

12 December 2020

Changes in gentamicin pharmacokinetic profiles induced by mechanical ventilation

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12 December 2020

Dynamics of the action of penicillin in experimental animals; observations on mice

1 reference

12 December 2020

Continuous infusion ceftazidime in intensive care: a randomized controlled trial

1 reference

12 December 2020

Clinical pharmacokinetics of piperacillin-tazobactam combination in patients with major burns and signs of infection

1 reference

12 December 2020

Should continuous infusion of beta-lactam antibiotics be the first-line approach?

1 reference

12 December 2020

Pharmacokinetics of amoxycillin/clavulanic acid in serum and ascitic fluid in cirrhotic patients

1 reference

12 December 2020

The inductive role of ionic binding in the bactericidal and postexposure effects of aminoglycoside antibiotics with implications for dosing

1 reference

12 December 2020

Aztreonam pharmacokinetics in burn patients

1 reference

12 December 2020

In vivo postantibiotic effect in a thigh infection in neutropenic mice

1 reference

12 December 2020

Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration

1 reference

12 December 2020

The use of glycopeptides in intensive care and anaesthesia

1 reference

12 December 2020

Intravenous cefotaxime in children with bacterial meningitis

1 reference

12 December 2020

Pharmacokinetics of ceftazidime in serum and suction blister fluid during continuous and intermittent infusions in healthy volunteers

1 reference

12 December 2020

Continuous versus intermittent infusion of vancomycin in severe Staphylococcal infections: prospective multicenter randomized study

1 reference

12 December 2020

The penetration of imipenem/cilastatin into ascitic fluid in patients with chronic liver disease

1 reference

12 December 2020

Penetration of antibiotics into the cerebro-spinal fluid in inflammatory conditions. 3. Gentamicin

1 reference

12 December 2020

Bile levels of imipenem in patients with T-drain following the administration of imipenem/cilastatin

1 reference

12 December 2020

In vivo efficacy of continuous infusion versus intermittent dosing of linezolid compared to vancomycin in a methicillin-resistant Staphylococcus aureus rabbit endocarditis model.

1 reference

12 December 2020

Challenges to antibiotic activity in tissue

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12 December 2020

Effect of the ratio of surface area to volume on the penetration of antibiotics in to extravascular spaces in an in vitro model

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12 December 2020

Penetration of intravenous and oral ciprofloxacin into sterile and empyemic human pleural fluid

1 reference

12 December 2020

Questioning dosing regimens of ciprofloxacin

1 reference

12 December 2020

The entry of antibiotics into human monocytes

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12 December 2020

Pharmacokinetics and ascitic fluid penetration of piperacillin in cirrhosis

1 reference

12 December 2020

Intraphagocytic penetration of antibiotics

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12 December 2020

Pharmacodynamic effects of ciprofloxacin, fleroxacin and lomefloxacin in vivo and in vitro.

1 reference

12 December 2020

Penetration of ceftazidime into human tissue in patients undergoing cardiac surgery

1 reference

12 December 2020

Pharmacokinetics of ceftazidime and ceftriaxone and their penetration into the ascitic fluid

1 reference

12 December 2020

In vivo and in vitro study of several pharmacodynamic effects of meropenem

1 reference

12 December 2020

Optimizing aminoglycoside therapy for nosocomial pneumonia caused by gram-negative bacteria

1 reference

12 December 2020

Penetration of aminoglycosides in uninfected pleural exudates and in pleural empyemas

1 reference

12 December 2020

Effect of schedule of administration on the therapeutic efficacy of penicillin; importance of the aggregate time penicillin remains at effectively bactericidal levels

1 reference

12 December 2020

The postantibiotic effect of antifungal agents against common pathogenic yeasts

1 reference

12 December 2020

Clinical significance of tissue penetration of antibiotics in the respiratory tract

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12 December 2020

Serum bactericidal activity of ceftazidime: continuous infusion versus intermittent injections.

1 reference

12 December 2020

Pharmacokinetic profiles of high-dose intravenous ciprofloxacin in severe sepsis. The Baragwanath Ciprofloxacin Study Group

1 reference

12 December 2020

The selection of appropriate dosages for intravenous ciprofloxacin

1 reference

12 December 2020

Imipenem penetration into bronchial secretions

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12 December 2020

Correlation of pharmacokinetic indices with therapeutic outcome in patients receiving aminoglycosides

1 reference

12 December 2020

Antibiotic dosing issues in lower respiratory tract infection: population-derived area under inhibitory curve is predictive of efficacy

1 reference

12 December 2020

10.1007/S00134-004-2428-9

Identifiers

DOI

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11 August 2017

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