sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers (Q35945633)

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English	sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers	scientific article

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scholarly article

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Europe PubMed Central

11 August 2017

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers (English)

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Europe PubMed Central

11 August 2017

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Alzheimer's disease

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cerebrospinal fluid

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Christine Van Broeckhoven

21

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Christine Van Broeckhoven

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Kristel Sleegers

20

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Kristel Sleegers

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11 August 2017

Christian Haass

27

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Christian Haass

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Sebastiaan Engelborghs

19

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Sebastiaan Engelborghs

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11 August 2017

Marc Suárez-Calvet

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Marc Suárez-Calvet

1

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Daniel A. Alcolea

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Daniel Alcolea

6

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Joan Domingo Gispert

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Juan Domingo Gispert

10

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José Luis Molinuevo

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José L Molinuevo

14

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Henrik Zetterberg

22

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Henrik Zetterberg

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11 August 2017

24

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Kaj Blennow

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11 August 2017

Gernot Kleinberger

2

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Gernot Kleinberger

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5

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Axel Rominger

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11 August 2017

Matthias Brendel

4

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Matthias Brendel

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11 August 2017

Miguel Ángel Araque Caballero

3

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Miguel Ángel Araque Caballero

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11 August 2017

8

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Alberto Lleó

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11 August 2017

Raquel Sanchez-Valle

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object named as

Raquel Sánchez-Valle

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11 August 2017

12

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Anna Antonell

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11 August 2017

13

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Lorena Rami

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11 August 2017

Michael T Heneka

17

object named as

Michael T Heneka

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11 August 2017

author name string

Juan Fortea

7

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11 August 2017

Rafael Blesa

9

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11 August 2017

Frederic Brosseron

15

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11 August 2017

Andreas Traschütz

16

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11 August 2017

Hanne Struyfs

18

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11 August 2017

Bengt Nellgård

23

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11 August 2017

Alexander Crispin

25

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11 August 2017

Michael Ewers

26

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11 August 2017

publication date

3 March 2016

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11 August 2017

EMBO Molecular Medicine

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11 August 2017

8

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11 August 2017

466-476

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5

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11 August 2017

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

Neuroinflammation in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology

1 reference

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2 October 2017

Microglial pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

1 reference

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2 October 2017

Body fluid cytokine levels in mild cognitive impairment and Alzheimer's disease: a comparative overview

1 reference

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2 October 2017

Microglial dysfunction in brain aging and Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

Heterozygous TREM2 mutations in frontotemporal dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement

1 reference

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2 October 2017

TREM2 Variants in Alzheimer's Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

1 reference

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2 October 2017

An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

1 reference

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2 October 2017

Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

1 reference

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2 October 2017

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

1 reference

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2 October 2017

Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

1 reference

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2 October 2017

The TREM receptor family and signal integration

1 reference

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2 October 2017

Intrathecal chemokine synthesis in mild cognitive impairment and Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features

1 reference

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2 October 2017

Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

1 reference

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A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

2 October 2017

Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

11 July 2018

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

11 July 2018

Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

11 July 2018

Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5120370

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Frequency of stages of Alzheimer-related lesions in different age categories

1 reference

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Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic and very mild Alzheimer's disease.

1 reference

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In Vivo Detection of Age- and Disease-Related Increases in Neuroinflammation by 18F-GE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer's Transgenic Mice.

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24 September 2018

TREM2 and Risk of Alzheimer's Disease--Friend or Foe?

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24 September 2018

The clinical use of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative.

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24 September 2018

Depression in mild cognitive impairment is associated with progression to Alzheimer's disease: a longitudinal study

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Relationship between β-Secretase, inflammation and core cerebrospinal fluid biomarkers for Alzheimer's disease.

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Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia.

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24 September 2018

Different profiles of Alzheimer's disease cerebrospinal fluid biomarkers in controls and subjects with subjective memory complaints.

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Altered plasma cytokine levels in Alzheimer's disease: correlation with the disease progression.

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24 September 2018

Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS.

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Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses?

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Neuropathological and neuropsychological changes in "normal" aging: evidence for preclinical Alzheimer disease in cognitively normal individuals.

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24 September 2018

Identifiers

10.15252/EMMM.201506123

1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

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