The molecular classification of medulloblastoma: driving the next generation clinical trials (Q35946293)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22189395%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

The molecular classification of medulloblastoma: driving the next generation clinical trials (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22189395%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

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1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22189395%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

James M Olson

series ordinal

2

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19 January 2020

publication date

1 February 2012

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22189395%20AND%20SRC:MED&resulttype=core&format=json

Current Opinion in Pediatrics

19 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22189395%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

volume

24

1 reference

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19 January 2020

issue

1

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19 January 2020

page(s)

33-39

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22189395%20AND%20SRC:MED&resulttype=core&format=json

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

19 January 2020

cites work

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Histology predicts a favorable outcome in young children with desmoplastic medulloblastoma: a report from the children's oncology group.

2 October 2017

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2 October 2017

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Subtypes of medulloblastoma have distinct developmental origins

2 October 2017

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Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

2 October 2017

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A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models

2 October 2017

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2 October 2017

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Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis

2 October 2017

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Definition of Disease-Risk Stratification Groups in Childhood Medulloblastoma Using Combined Clinical, Pathologic, and Molecular Variables

2 October 2017

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Medulloblastoma comprises four distinct molecular variants

2 October 2017

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Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children's Oncology Group phase I consortium report

2 October 2017

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2 October 2017

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

2 October 2017

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Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

2 October 2017

1 reference

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Pediatric medulloblastoma: toxicity of current treatment and potential role of protontherapy

2 October 2017

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Treatment of early childhood medulloblastoma by postoperative chemotherapy and deferred radiotherapy

2 October 2017

1 reference

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Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features

2 October 2017

1 reference

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Proton versus photon radiotherapy for common pediatric brain tumors: comparison of models of dose characteristics and their relationship to cognitive function

2 October 2017

1 reference

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Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic acid (SAHA).

2 October 2017

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Which clinical and biological tumor markers proved predictive in the prospective multicenter trial HIT'91--implications for investigating childhood medulloblastoma

2 October 2017

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The 2007 WHO classification of tumours of the central nervous system

2 October 2017

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Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations

2 October 2017

1 reference

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Outcome for children <4 years of age with malignant central nervous system tumors treated with high-dose chemotherapy and autologous stem cell rescue

2 October 2017

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Molecular genetics of supratentorial primitive neuroectodermal tumors and pineoblastoma

2 October 2017

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Multiagent chemotherapy and deferred radiotherapy in infants with malignant brain tumors: a report from the Children's Cancer Group

2 October 2017

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Treatment strategies for high-risk medulloblastoma and supratentorial primitive neuroectodermal tumors. Review of the literature

2 October 2017

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Intellectual and functional outcome of children 3 years old or younger who have CNS malignancies

2 October 2017

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Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells

2 October 2017

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Concurrent chemotherapy and reduced-dose cranial spinal irradiation followed by conformal posterior fossa tumor bed boost for average-risk medulloblastoma: efficacy and patterns of failure

2 October 2017

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Medulloblastoma: present concepts of stratification into risk groups

2 October 2017

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Retinoic acid decreases targeting of p27 for degradation via an N-myc-dependent decrease in p27 phosphorylation and an N-myc-independent decrease in Skp2.

2 October 2017

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MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group

2 October 2017

1 reference

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Prediction of central nervous system embryonal tumour outcome based on gene expression

2 October 2017

1 reference

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Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32.

2 October 2017

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Expression of the c-Myc protein in childhood medulloblastoma

2 October 2017

1 reference

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Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

2 October 2017

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Human homolog of patched, a candidate gene for the basal cell nevus syndrome

2 October 2017

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Results of treatment of children with recurrent medulloblastoma/primitive neuroectodermal tumors with lomustine, cisplatin, and vincristine

2 October 2017

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Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts

2 October 2017

1 reference

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N-myc and c-myc oncogenes amplification in medulloblastomas. Evidence of particularly aggressive behavior of a tumor with c-myc amplification.

27 July 2018

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Radiobiological risk estimates of adverse events and secondary cancer for proton and photon radiation therapy of pediatric medulloblastoma

27 July 2018

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Adult medulloblastoma comprises three major molecular variants.

24 September 2018

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Disease control and ototoxicity using intensity-modulated radiation therapy tumor-bed boost for medulloblastoma

24 September 2018

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Treatment of recurrent central nervous system primitive neuroectodermal tumours in children and adolescents: results of a Children's Cancer and Leukaemia Group study.

24 September 2018

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Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification

24 September 2018

1 reference

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Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors

24 September 2018

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Identification of a SUFU germline mutation in a family with Gorlin syndrome.

24 September 2018

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Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics

24 September 2018

1 reference

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Molecular risk stratification of medulloblastoma patients based on immunohistochemical analysis of MYC, LDHB, and CCNB1 expression

24 September 2018

1 reference

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The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread.

24 September 2018

1 reference

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Outcome of children less than three years old at diagnosis with non-metastatic medulloblastoma treated with chemotherapy on the "Head Start" I and II protocols.

24 September 2018

1 reference

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Supratentorial primitive neuroectodermal tumors: a Canadian pediatric brain tumor consortium report

24 September 2018

1 reference

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Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial

24 September 2018

1 reference

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Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma.

24 September 2018

1 reference

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Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma

24 September 2018

1 reference

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Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children.

24 September 2018

1 reference

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Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients.

24 September 2018

1 reference

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Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348176

c-Myc promoter activation in medulloblastoma.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348176

MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/medulloblastoma.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348176

Patterns of intellectual development among survivors of pediatric medulloblastoma: a longitudinal analysis.

24 September 2018

1 reference

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Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.

24 September 2018

1 reference

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"Large cell/anaplastic" medulloblastomas: a Pediatric Oncology Group Study.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348176

C-MYC expression in medulloblastoma and its prognostic value.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348176

Oncogene amplification in pediatric brain tumors.

24 September 2018

1 reference

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Large-cell medulloblastomas. A distinct variant with highly aggressive behavior

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348176

Outcome for children with supratentorial primitive neuroectodermal tumors treated with surgery, radiation, and chemotherapy

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22189395

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1097/MOP.0B013E32834EC106

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22189395%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22189395%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

22189395

1 reference