Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity (Q35950846)

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27 January 2020

title

Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity (English)

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27 January 2020

3

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27 January 2020

author name string

Noortje M van Maarseveen

1

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27 January 2020

Dan Andersson

2

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27 January 2020

Axel Fun

4

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27 January 2020

Pauline J Schipper

5

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27 January 2020

Dorien de Jong

6

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27 January 2020

Charles A B Boucher

7

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27 January 2020

Monique Nijhuis

8

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27 January 2020

publication date

1 April 2012

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27 January 2020

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27 January 2020

volume

9

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27 January 2020

page(s)

29

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https://scigraph.springernature.com/pub.10.1186/1742-4690-9-29

27 January 2020

exact match

0 references

cites work

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Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease

2 October 2017

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Changes in human immunodeficiency virus type 1 Gag at positions L449 and P453 are linked to I50V protease mutants in vivo and cause reduction of sensitivity to amprenavir and improved viral fitness in vitro

2 October 2017

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2 October 2017

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2 October 2017

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Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: phenotypic analysis of protease and gag coevolution in protease inhibitor-treated patients

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Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites

2 October 2017

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Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors

2 October 2017

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Crossref

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An increase in viral replicative capacity drives the evolution of protease inhibitor-resistant human immunodeficiency virus type 1 in the absence of drugs

21 January 2018

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21 January 2018

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21 January 2018

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A novel real-time PCR assay to determine relative replication capacity for HIV-1 protease variants and/or reverse transcriptase variants

24 September 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22462820

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22462820

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1742-4690-9-29

1 reference

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Dimensions Publication ID

27 January 2020

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27 January 2020

1 reference

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