Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells (Q35956150)

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8 February 2020

title

Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells (English)

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8 February 2020

4

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8 February 2020

Shoukat Dedhar

10

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8 February 2020

Michael S Parmacek

11

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author name string

Dongxiao Shen

1

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8 February 2020

Jian Li

2

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8 February 2020

John J Lepore

3

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8 February 2020

Sumita Sinha

5

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8 February 2020

Alexander Y Lin

6

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8 February 2020

Lan Cheng

7

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Ethan David Cohen

8

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Jesse D Roberts

9

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8 February 2020

Robert E Gerszten

12

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8 February 2020

language of work or name

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21 July 2011

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8 February 2020

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8 February 2020

volume

109

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8 February 2020

issue

6

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8 February 2020

page(s)

616-628

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Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation

8 February 2020

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1 reference

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Integrin-linked kinase in the vascular smooth muscle cell response to injury

2 October 2017

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Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL.

2 October 2017

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Force activates smooth muscle alpha-actin promoter activity through the Rho signaling pathway

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Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome

2 October 2017

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Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival

2 October 2017

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Integrin-linked kinase is responsible for Ca2+-independent myosin diphosphorylation and contraction of vascular smooth muscle

2 October 2017

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GATA-6 regulates genes promoting synthetic functions in vascular smooth muscle cells

2 October 2017

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Integrin-linked kinase regulates endothelial cell survival and vascular development.

2 October 2017

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Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells

2 October 2017

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Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes

2 October 2017

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The integrin-actin connection, an eternal love affair

2 October 2017

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Actin dynamics control SRF activity by regulation of its coactivator MAL

2 October 2017

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Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation

2 October 2017

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Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation

2 October 2017

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Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation.

2 October 2017

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Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome

2 October 2017

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A critical role for elastin signaling in vascular morphogenesis and disease

2 October 2017

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Integrins: bidirectional, allosteric signaling machines

2 October 2017

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Ca2+-independent smooth muscle contraction. a novel function for integrin-linked kinase

2 October 2017

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Analysis of SM22alpha-deficient mice reveals unanticipated insights into smooth muscle cell differentiation and function

2 October 2017

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Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion

2 October 2017

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Smooth muscle differentiation marker gene expression is regulated by RhoA-mediated actin polymerization

2 October 2017

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Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

2 October 2017

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Integrin-linked kinase and PINCH: partners in regulation of cell-extracellular matrix interaction and signal transduction.

2 October 2017

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2 October 2017

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Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

2 October 2017

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Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways

2 October 2017

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Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity

2 October 2017

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2 October 2017

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Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase

2 October 2017

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2 October 2017

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2 October 2017

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Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton

2 October 2017

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Unique geometry of actin-membrane anchorage sites in avian gizzard smooth muscle cells

2 October 2017

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Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction

2 October 2017

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Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure

11 July 2018

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PI3-kinase/Akt modulates vascular smooth muscle tone via cAMP signaling pathways

11 July 2018

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Phosphatidylinositol 3-kinase modulates vascular smooth muscle contraction by calcium and myosin light chain phosphorylation-independent and -dependent pathways

11 July 2018

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C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes

24 September 2018

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Integrin receptors on aortic smooth muscle cells mediate adhesion to fibronectin, laminin, and collagen

24 September 2018

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Isolation of vascular smooth muscle cells from a single murine aorta

24 September 2018

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12 December 2020

High-efficiency somatic mutagenesis in smooth muscle cells and cardiac myocytes in SM22alpha-Cre transgenic mice

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12 December 2020

Role of integrin-linked kinase in vascular smooth muscle cells: regulation by statins and angiotensin II

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12 December 2020

Osteopontin stimulates vascular smooth muscle cell migration by inducing FAK phosphorylation and ILK dephosphorylation

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12 December 2020

Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro

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12 December 2020

10.1161/CIRCRESAHA.110.239343

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778429%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

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8 February 2020

PubMed publication ID

21778429

1 reference