Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism? (Q35956848)

11 August 2017

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title

Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism? (English)

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11 August 2017

Spahn-Langguth H

1

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PubMed ID

1555494

11 August 2017

Benet LZ

series ordinal

2

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PubMed ID

1555494

11 August 2017

language of work or name

English

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publication date

1 January 1992

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11 August 2017

Drug Metabolism Reviews

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11 August 2017

24

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11 August 2017

5-47

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11 August 2017

1

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Properties of acyl glucuronides: implications for studies of the pharmacokinetics and metabolism of acidic drugs

11 August 2017

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The significance of phase II (conjugation) reactions in drug disposition and toxicity

21 January 2018

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Contrasting systemic stabilities of the acyl and phenolic glucuronides of diflunisal in the rat

21 January 2018

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Separation of two conjugates of clofibric acid (CPIB) found in the urine of subjects taking clofibrate

21 January 2018

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The formation of beta-glucuronidase resistant glucuronides by the intramolecular rearrangement of glucuronic acid conjugates at mild alkaline pH.

21 January 2018

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Irreversible binding of tolmetin glucuronic acid esters to albumin in vitro

21 January 2018

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Procedures to characterize in vivo and in vitro enantioselective glucuronidation properly: studies with benoxaprofen glucuronides

21 January 2018

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The fate of bilirubin-IXα glucuronide in cholestasis and during storage in vitro. Intramolecular rearrangement to positional isomers of glucuronic acid

21 January 2018

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pH dependent formation of beta-glucuronidase resistant conjugates from the biosynthetic ester glucuronide of isoxepac.

21 January 2018

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Irreversible binding of zomepirac to plasma protein in vitro and in vivo

21 January 2018

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Immobilized glucuronosyltransferase for the synthesis of conjugates

21 January 2018

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Micro-analytic detection and structure elucidation of ester-glycosides

21 January 2018

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Simultaneous determination of gemfibrozil and its metabolites in plasma and urine by a fully automated high performance liquid chromatographic system

21 January 2018

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The Fate of Bilirubin-IXα Glucuronides in Cholestatic Bile: Sequential Migration of the 1-Acylaglycone to the 2-, 3- and 4-Positions of Glucuronic Acid

21 January 2018

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Clofibrate disposition in renal failure and acute and chronic liver disease

21 January 2018

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Effect of probenecid on the formation and elimination of acyl glucuronides: studies with zomepirac.

21 January 2018

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The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences

21 January 2018

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Biotransformation and excretion of lorazepam in patients with chronic renal failure

21 January 2018

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Plasma half-life of clofibric acid in renal failure

21 January 2018

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Biotransformation of diflunisal and renal excretion of its glucuronides in renal insufficiency

21 January 2018

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Pharmacokinetics of ketoprofen in the elderly

21 January 2018

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Reduced elimination of ketoprofen in the elderly is not necessarily due to impaired glucuronidation

21 January 2018

1 reference

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Probenecid-induced changes in the clearance of carprofen enantiomers: a preliminary study

21 January 2018

1 reference

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Effects of probenecid on ketoprofen kinetics

21 January 2018

1 reference

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Effect of dose on the glucuronidation and sulphation kinetics of diflunisal in man: single dose studies

21 January 2018

1 reference

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Disposition and irreversible plasma protein binding of tolmetin in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996289

Stereoselective binding of the glucuronide conjugates of carprofen enantiomers to human serum albumin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996289

Irreversible binding of conjugated bilirubin to albumin in cholestatic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539208996289

Origin of mammalian biliprotein and rearrangement of bilirubin glucuronides in vivo in the rat

21 January 2018

1 reference

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Analyses of azopigments obtained from the delta fraction of bilirubin from mammalian plasma (mammalian biliprotein).

21 January 2018

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Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications

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The Glycosylation of Hemoglobin: Relevance to Diabetes Mellitus

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Detection of a protein-acetaldehyde adduct in the liver of rats fed alcohol chronically

21 January 2018

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Leukotrienes: regulation of biosynthesis, metabolism, and bioactivity

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Liquid chromatographic assay for the measurement of glucuronidation of arylcarboxylic acids using uridine diphospho-[U-14C]glucuronic acid

21 January 2018

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10.3109/03602539208996289

21 January 2018

Identifiers

DOI

1 reference

11 August 2017

1 reference

PubMed ID

1555494