Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility (Q35958226)

11 August 2017

Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility (English)

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11 August 2017

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ChEBI release 2020-05-28

Koji Takeuchi

1

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PMCID

3351764

11 August 2017

language of work or name

English

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publication date

1 May 2012

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World Journal of Gastroenterology

11 August 2017

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11 August 2017

18

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11 August 2017

18

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11 August 2017

2147-2160

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Translocation of heme oxygenase-1 to mitochondria is a novel cytoprotective mechanism against non-steroidal anti-inflammatory drug-induced mitochondrial oxidative stress, apoptosis, and gastric mucosal injury.

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

A role for HSP70 in protecting against indomethacin-induced gastric lesions

2 October 2017

1 reference

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Gastric mucosal defense and cytoprotection: bench to bedside

2 October 2017

1 reference

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Effect of (S)-4-(1-(5-chloro-2-(4-fluorophenyoxy)benzamido)ethyl) benzoic acid (CJ-42794), a selective antagonist of prostaglandin E receptor subtype 4, on ulcerogenic and healing responses in rat gastrointestinal mucosa

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Oral but not parenteral aspirin upregulates COX-2 expression in rat stomachs. a relationship between COX-2 expression and PG deficiency

2 October 2017

1 reference

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Gastritis increases resistance to aspirin-induced mucosal injury via COX-2-mediated lipoxin synthesis

2 October 2017

1 reference

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Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Ulcerogenic influence of selective cyclooxygenase-2 inhibitors in the rat stomach with adjuvant-induced arthritis

2 October 2017

1 reference

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Prevention by parenteral aspirin of indomethacin-induced gastric lesions in rats: mediation by salicylic acid

2 October 2017

1 reference

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Alteration of gastric ulcerogenic and healing responses in rats with adjuvant-induced arthritis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Up-regulation of COX-2 by inhibition of COX-1 in the rat: a key to NSAID-induced gastric injury

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

The roles of prostaglandin E receptor subtypes in the cytoprotective action of prostaglandin E2 in rat stomach

2 October 2017

1 reference

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Prostanoid receptors: structures, properties, and functions

2 October 2017

2 references

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2 October 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Indomethacin induced gastropathy in CD18, intercellular adhesion molecule 1, or P-selectin deficient mice

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB.

2 October 2017

1 reference

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Gastric mucosal contraction and vascular injury induced by indomethacin precede neutrophil infiltration in the rat.

2 October 2017

1 reference

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NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Relationship between gastric mucosal hemodynamics and gastric motility

2 October 2017

1 reference

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Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

2 October 2017

1 reference

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Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats. Relation to gastric hypermotility

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Prostaglandin E inhibits indomethacin-induced gastric lesions through EP-1 receptors

2 October 2017

1 reference

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Investigation of the inhibitory effects of PGE2 and selective EP agonists on chemotaxis of human neutrophils

11 July 2018

1 reference

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Pentoxifylline prevents indomethacin induced acute gastric mucosal damage in rats: role of tumour necrosis factor alpha

11 July 2018

1 reference

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The relationship between serum gastrin, gastric ulceration and basal acid output in the polyarthritic rat.

11 July 2018

1 reference

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Letter: Ulcerogenic potential of indomethacin in arthritic and non-arthritic rats

11 July 2018

1 reference

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Gastric motility is a major factor in cold restraint-induced lesion formation in rats.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Gastric motility is an important factor in the pathogenesis of indomethacin-induced gastric mucosal lesions in rats

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Role of prostaglandin deficiency in pathogenetic mechanism of gastric lesions induced by indomethacin in rats

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Increased microvascular permeability and lesion formation during gastric hypermotility caused by indomethacin and 2-deoxy-D-glucose in the rat.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Gastric microvascular endothelium: a major target for aspirin-induced injury and arachidonic acid protection. An ultrastructural analysis in the rat.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Indomethacin-induced leukocyte adhesion in mesenteric venules: role of lipoxygenase products

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Preconditioning stress prevents cold restraint stress-induced gastric lesions in rats: roles of COX-1, COX-2, and PLA2.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Involvement of intracellular Ca2+ levels in nonsteroidal anti-inflammatory drug-induced apoptosis

24 September 2018

1 reference

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Functional mechanism underlying COX-2 expression following administration of indomethacin in rat stomachs: importance of gastric hypermotility

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Both selective COX-1 and COX-2 inhibitors aggravate gastric damage induced in rats by 2-deoxy-D-glucose. relation to gastric hypermotility and COX-2 expression

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Role of cyclooxygenase (COX)-1 and COX-2 inhibition in nonsteroidal anti-inflammatory drug-induced intestinal damage in rats: relation to various pathogenic events

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Up-regulation of cyclooxygenase-2 by inhibition of cyclooxygenase-1: a key to nonsteroidal anti-inflammatory drug-induced intestinal damage

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Inhibition of both COX-1 and COX-2 is required for development of gastric damage in response to nonsteroidal antiinflammatory drugs

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Neutrophil infiltration does not contribute to the ulcerogenic effects of indomethacin in the rat gastric antrum.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351764

Gallic acid prevents nonsteroidal anti-inflammatory drug-induced gastropathy in rat by blocking oxidative stress and apoptosis

24 September 2018

1 reference

12 December 2020

Effect of acetylsalicylic and 2,3-dihydroxybenzoic acids on liver mitochondrial respiration in rats

1 reference

12 December 2020

Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat

1 reference

12 December 2020

Gastric cytoprotection by sodium salicylate

1 reference

12 December 2020

Prevention of phenylbutazone ulcer in the rat by glucose: role of a glycoprivic receptor system

1 reference

12 December 2020

Contractile responses of longitudinal and circular smooth muscle of the canine stomach to prostaglandins E and F2alpha

1 reference

12 December 2020

Endoscopic studies of gastric and duodenal injury after the use of ibuprofen, aspirin, and other nonsteroidal anti-inflammatory agents

1 reference

12 December 2020

Alterations in the gastro-intestinal functions during the development of adjuvant disease in rats

1 reference

12 December 2020

Importance of gastric motility in the pathogenesis of indomethacin-induced gastric lesions in rats

1 reference

12 December 2020

Delayed healing of acetic acid-induced gastric ulcers in rats by indomethacin

1 reference

12 December 2020

Bilateral adrenalectomy worsens gastric mucosal lesions induced by indomethacin in the rat. Role of enhanced gastric motility

1 reference

12 December 2020

Possible mechanisms involved in gastric hypermotility caused by indomethacin in the rat. Role of glycoprivic response

1 reference

12 December 2020

Role of epidermal growth factor, prostaglandin, and sulfhydryls in stress-induced gastric lesions

1 reference

12 December 2020

NSAID-induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2

1 reference

12 December 2020

Role of cyclooxygenase-2 in Helicobacter pylori- induced gastritis in Mongolian gerbils

1 reference

12 December 2020

Permissive role of neutrophils in pathogenesis of indomethacin-induced gastric lesions in rats

1 reference

12 December 2020

Pathogenesis of NSAID gastropathy: are neutrophils the culprits?

1 reference

12 December 2020

Role of tumor necrosis factor alpha release and leukocyte margination in indomethacin-induced gastric injury in rats

1 reference

12 December 2020

Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat

1 reference

12 December 2020

Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts

1 reference

12 December 2020

Diethyldithiocarbamate, a superoxide dismutase inhibitor, reduces indomethacin-induced gastric lesions in rats

1 reference

12 December 2020

Cellular localization of mRNAs for prostaglandin E receptor subtypes in mouse gastrointestinal tract

1 reference

12 December 2020

Analysis of pathogenic elements involved in gastric lesions induced by non-steroidal anti-inflammatory drugs in rats

1 reference

12 December 2020

Distribution of prostaglandin E receptors in the rat gastrointestinal tract

1 reference

12 December 2020

Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach

1 reference

12 December 2020

Changes in gastric mucosal ulcerogenic responses in rats with adjuvant arthritis: role of nitric oxide

1 reference

12 December 2020

Identifiers

DOI

10.3748/WJG.V18.I18.2147

1 reference

11 August 2017

1 reference

11 August 2017

1 reference

PMCID

3351764