Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes (Q35964119)

11 August 2017

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title

Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes (English)

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11 August 2017

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Michael J Riedel

1

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PubMed ID

15565284

11 August 2017

Diana C Steckley

series ordinal

2

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PubMed ID

15565284

11 August 2017

Peter E Light

series ordinal

3

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11 August 2017

23 November 2004

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11 August 2017

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11 August 2017

116

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11 August 2017

3

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11 August 2017

133-145

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https://scigraph.springernature.com/pub.10.1007/s00439-004-1216-5

11 August 2017

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cites work

C-terminal tails of sulfonylurea receptors control ADP-induced activation and diazoxide modulation of ATP-sensitive K(+) channels

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00439-004-1216-5

A gene knockout approach in mice to identify glucose sensors controlling glucose homeostasis

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00439-004-1216-5

Modulation of force development by Na+, K+, Na+ K+ pump and KATP channel during muscular activity.

21 January 2018

1 reference

12 December 2020

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

1 reference

12 December 2020

K(ATP) channels and insulin secretion disorders

1 reference

12 December 2020

Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53).

1 reference

12 December 2020

Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle

1 reference

12 December 2020

Activation of the ATP-sensitive K+ channel by long chain acyl-CoA. A role in modulation of pancreatic beta-cell glucose sensitivity.

1 reference

12 December 2020

Intracerebroventricular infusion of a triglyceride emulsion leads to both altered insulin secretion and hepatic glucose production in rats

1 reference

12 December 2020

The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide

1 reference

12 December 2020

Association and stoichiometry of K(ATP) channel subunits

1 reference

12 December 2020

Metabolic and genetic influence on glucose metabolism in type 2 diabetic subjects--experiences from relatives and twin studies

1 reference

12 December 2020

E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPARgamma Pro12Ala variant.

1 reference

12 December 2020

Molecular mechanism for ATP-dependent closure of the K+ channel Kir6.2

1 reference

12 December 2020

Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro

1 reference

12 December 2020

Acyl-CoA esters modulate intracellular Ca2+ handling by permeabilized clonal pancreatic beta-cells

1 reference

12 December 2020

Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins

1 reference

12 December 2020

ATP-sensitive K+ channels in pancreatic beta-cells. Spare-channel hypothesis.

1 reference

12 December 2020

Effect of AMPK activation on muscle glucose metabolism in conscious rats

1 reference

12 December 2020

Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor

1 reference

12 December 2020

Glucose-sensing in glucagon-like peptide-1-secreting cells

1 reference

12 December 2020

Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle.

1 reference

12 December 2020

Pharmaco-topology of sulfonylurea receptors. Separate domains of the regulatory subunits of K(ATP) channel isoforms are required for selective interaction with K(+) channel openers

1 reference

12 December 2020

A novel method for measurement of submembrane ATP concentration.

1 reference

12 December 2020

Adenosine diphosphate as an intracellular regulator of insulin secretion.

1 reference

12 December 2020

Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport.

1 reference

12 December 2020

Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians

1 reference

12 December 2020

Identification of the potassium channel opener site on sulfonylurea receptors

1 reference

12 December 2020

Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution

1 reference

12 December 2020

The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes

1 reference

12 December 2020

Physical activity, energy expenditure and fitness: an evolutionary perspective

1 reference

12 December 2020

K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels

1 reference

12 December 2020

Genomic variation in pancreatic ion channel genes in Japanese type 2 diabetic patients

1 reference

12 December 2020

Growing evidence for diabetes susceptibility genes from genome scan data

1 reference

12 December 2020

Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action

1 reference

12 December 2020

Long chain coenzyme A esters activate the pore-forming subunit (Kir6. 2) of the ATP-regulated potassium channel.

1 reference

12 December 2020

Peroxisome proliferator-activated receptor gamma in diabetes and metabolism

1 reference

12 December 2020

ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis.

1 reference

12 December 2020

The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion

1 reference

12 December 2020

Variants in the sulphonylurea receptor gene: association of the exon 16-3t variant with Type II diabetes mellitus in Dutch Caucasians

1 reference

12 December 2020

Eating, exercise, and "thrifty" genotypes: connecting the dots toward an evolutionary understanding of modern chronic diseases

1 reference

12 December 2020

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

1 reference

12 December 2020

5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle

1 reference

12 December 2020

Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM.

1 reference

12 December 2020

Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM.

1 reference

12 December 2020

Effect of obesity on ambient plasma glucose, free fatty acid, insulin, growth hormone, and glucagon concentrations.

1 reference

12 December 2020

Triggering and amplifying pathways of regulation of insulin secretion by glucose

1 reference

12 December 2020

Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis

1 reference

12 December 2020

Physiology and pathophysiology of K(ATP) channels in the pancreas and cardiovascular system: a review

1 reference

12 December 2020

Genetic variability of the SUR1 promoter in relation to beta-cell function and Type II diabetes mellitus

1 reference

12 December 2020

Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes?

1 reference

12 December 2020

Octameric stoichiometry of the KATP channel complex

1 reference

12 December 2020

Improved energy homeostasis of the heart in the metabolic state of exercise.

1 reference

12 December 2020

Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

1 reference

12 December 2020

Phosphatidylinositol 4,5-bisphosphate (PIP2) modulation of ATP and pH sensitivity in Kir channels. A tale of an active and a silent PIP2 site in the N terminus

1 reference

12 December 2020

Sequence variants in the pancreatic islet beta-cell inwardly rectifying K+ channel Kir6.2 (Bir) gene: identification and lack of role in Caucasian patients with NIDDM

1 reference

12 December 2020

Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cell

1 reference

12 December 2020

Crystal structure of the potassium channel KirBac1.1 in the closed state

1 reference

12 December 2020

Blocking ATP-sensitive K+ channel during metabolic inhibition impairs muscle contractility

1 reference

12 December 2020

The search for type 2 diabetes genes

1 reference

12 December 2020

The common single nucleotide polymorphism E23K in K(IR)6.2 sensitizes pancreatic beta-cell ATP-sensitive potassium channels toward activation through nucleoside diphosphates

1 reference

12 December 2020

Genes, environment and Oji-Cree type 2 diabetes

1 reference

12 December 2020

The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids

1 reference

12 December 2020

The Yin and Yang of the K(ATP) channel

1 reference

12 December 2020

Identification of residues contributing to the ATP binding site of Kir6.2.

1 reference

12 December 2020

Diabetes in identical twins. A study of 200 pairs

1 reference

12 December 2020

Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells

1 reference

12 December 2020

Molecular determinants of KATP channel inhibition by ATP.

1 reference

12 December 2020

Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion

1 reference

12 December 2020

Kir6.2 is required for adaptation to stress

1 reference

12 December 2020

Cell-type specific expression of ATP-sensitive potassium channels in the rat hippocampus.

1 reference

12 December 2020

Glucose generates sub-plasma membrane ATP microdomains in single islet beta-cells. Potential role for strategically located mitochondria.

1 reference

12 December 2020

The role of NH2-terminal positive charges in the activity of inward rectifier KATP channels

1 reference

12 December 2020

Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA

1 reference

12 December 2020

Evidence for a Unique Long Chain Acyl-CoA Ester Binding Site on the ATP-regulated Potassium Channel in Mouse Pancreatic Beta Cells

1 reference

12 December 2020

A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes

1 reference

12 December 2020

KATP channel formation by the sulphonylurea receptors SUR1 with Kir6.2 subunits in rat dorsal vagal neurons in situ

1 reference

12 December 2020

Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?

1 reference

12 December 2020

Effect of a diabetic environment in utero on predisposition to type 2 diabetes

1 reference

12 December 2020

Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians

1 reference

12 December 2020

Effects of glucose and amino acids on free ADP in betaHC9 insulin-secreting cells

1 reference

12 December 2020

Insulin secretion after short- and long-term low-grade free fatty acid infusion in men with increased risk of developing type 2 diabetes

1 reference

12 December 2020

Molecular biology of adenosine triphosphate-sensitive potassium channels

1 reference

12 December 2020

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

1 reference

12 December 2020

High-insulinogenic nutrition--an etiologic factor for obesity and the metabolic syndrome?

1 reference

12 December 2020

Electrophysiology of the pancreatic beta-cell

1 reference

12 December 2020

Toward understanding the assembly and structure of KATP channels

1 reference

12 December 2020

Effect of training on insulin-mediated glucose uptake in human muscle

1 reference

12 December 2020

Long-chain acyl-CoA esters and phosphatidylinositol phosphates modulate ATP inhibition of KATP channels by the same mechanism

1 reference

12 December 2020

Activation of adenosine triphosphate-sensitive potassium channels by acyl coenzyme A esters involves multiple phosphatidylinositol 4,5-bisphosphate-interacting residues

1 reference

12 December 2020

Regulation of KATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor

1 reference

12 December 2020

Environmental contributions to the obesity epidemic

1 reference

12 December 2020

The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction

1 reference

12 December 2020

Membrane phospholipid control of nucleotide sensitivity of KATP channels

1 reference

12 December 2020

Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

1 reference

12 December 2020

The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris Prospective Study.

1 reference

12 December 2020

Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

1 reference

12 December 2020

Perspective: the search for genes for type 2 diabetes in the post-genome era.

1 reference

12 December 2020

The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia

1 reference

12 December 2020

Analysis of acyl-coenzyme A esters in biological samples.

1 reference

12 December 2020

Nucleotide sensitivity of pancreatic ATP-sensitive potassium channels and type 2 diabetes

1 reference

12 December 2020

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor

1 reference

12 December 2020

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region

1 reference

12 December 2020

Peroxisome proliferator-activated receptor γ in diabetes and metabolism

1 reference

12 December 2020

10.1007/S00439-004-1216-5

Identifiers

DOI

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11 August 2017

1 reference

PubMed ID

15565284