Targeting malignant B cells with an immunotoxin against ROR1 (Q35969887)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22531447%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Targeting malignant B cells with an immunotoxin against ROR1 (English)

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29 January 2020

5

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3

Wyndham H Wilson

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29 January 2020

author name string

Sivasubramanian Baskar

series ordinal

1

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29 January 2020

Adrian Wiestner

series ordinal

2

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29 January 2020

Ira Pastan

series ordinal

4

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29 January 2020

publication date

26 April 2012

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29 January 2020

published in

Monoclonal Antibodies

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29 January 2020

volume

4

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29 January 2020

issue

3

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29 January 2020

page(s)

349-361

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Treatment-induced oxidative stress and cellular antioxidant capacity determine response to bortezomib in mantle cell lymphoma

29 January 2020

cites work

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Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies

2 October 2017

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Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis

2 October 2017

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Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes.

2 October 2017

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A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease

2 October 2017

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Phase I clinical trial of the chimeric anti-mesothelin monoclonal antibody MORAb-009 in patients with mesothelin-expressing cancers

2 October 2017

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The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor.

2 October 2017

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Stat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells

2 October 2017

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ABT-737 overcomes resistance to immunotoxin-mediated apoptosis and enhances the delivery of pseudomonas exotoxin-based proteins to the cell cytosol.

2 October 2017

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A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice.

2 October 2017

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Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase-dependent pathway

2 October 2017

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Variable contribution of monoclonal antibodies to ADCC in patients with chronic lymphocytic leukemia

2 October 2017

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Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia

2 October 2017

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CAT-8015: a second-generation pseudomonas exotoxin A-based immunotherapy targeting CD22-expressing hematologic malignancies

2 October 2017

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Flow cytometric analysis of mitochondrial membrane potential using JC-1.

2 October 2017

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Differential cellular internalization of anti-CD19 and -CD22 immunotoxins results in different cytotoxic activity

2 October 2017

1 reference

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Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy

2 October 2017

1 reference

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Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3355487

Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3355487

FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins

2 October 2017

1 reference

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Immunotoxins in the treatment of hematologic malignancies

2 October 2017

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Complement-induced cell death by rituximab depends on CD20 expression level and acts complementary to antibody-dependent cellular cytotoxicity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3355487

Recombinant immunotoxins in the treatment of cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3355487

Immunotoxins containing Pseudomonas exotoxin A: a short history

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3355487

Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

2 October 2017

1 reference

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Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells.

2 October 2017

1 reference

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2 October 2017

Caspases: enemies within

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Epstein-Barr virus susceptibility of normal human B lymphocyte populations

2 October 2017

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Pseudomonas exotoxin--immunotoxins.

2 October 2017

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The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia

2 October 2017

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A novel family of cell surface receptors with tyrosine kinase-like domain

2 October 2017

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Novel anti-CD30 recombinant immunotoxins containing disulfide-stabilized Fv fragments

2 October 2017

1 reference

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Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli.

11 July 2018

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Ricin A-chain containing immunotoxins directed against different epitopes on the CD2 molecule differ in their ability to kill normal and malignant T cells.

11 July 2018

1 reference

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Recombinant toxins containing the variable domains of the anti-Tac monoclonal antibody to the interleukin-2 receptor kill malignant cells from patients with chronic lymphocytic leukemia

11 July 2018

1 reference

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Immunotoxins directed against the high-molecular-weight melanoma-associated antigen. Identification of potent antibody-toxin combinations

11 July 2018

1 reference

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Monoclonal antibodies against ROR1 induce apoptosis of chronic lymphocytic leukemia (CLL) cells.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3355487

Silencing of ROR1 and FMOD with siRNA results in apoptosis of CLL cells.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3355487

Initial characterization of an immunotoxin constructed from domains II and III of cholera exotoxin

24 September 2018

1 reference

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Immunotoxin therapy of cancer

24 September 2018

1 reference

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Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

24 September 2018

1 reference

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Engineering antibody Fv fragments for cancer detection and therapy: disulfide-stabilized Fv fragments

24 September 2018

1 reference

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Influence of cellular trafficking on protein synthesis inhibition of immunotoxins directed against the transferrin receptor

24 September 2018

1 reference

12 December 2020

Interferon gamma induces upregulation and activation of caspases 1, 3, and 8 to produce apoptosis in human erythroid progenitor cells

1 reference

12 December 2020

Phase I trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with B-cell malignancies

1 reference

12 December 2020

Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias

1 reference

12 December 2020

Induction of caspase-dependent programmed cell death in B-cell chronic lymphocytic leukemia by anti-CD22 immunotoxins

1 reference

12 December 2020

Purine-rich box-1-mediated reduced expression of CD20 alters rituximab-induced lysis of chronic lymphocytic leukemia B cells

1 reference

12 December 2020

Immunotoxin BL22 induces apoptosis in mantle cell lymphoma (MCL) cells dependent on Bcl-2 expression

1 reference

12 December 2020

ROR1 expression is not a unique marker of CLL

1 reference

12 December 2020

Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers

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12 December 2020

Identifiers

DOI

10.4161/MABS.19870

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22531447%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

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29 January 2020

PubMed publication ID

22531447

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22531447%20AND%20SRC:MED&resulttype=core&format=json