Hitting multiple targets with multimeric ligands (Q35976363)

11 August 2017

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title

Hitting multiple targets with multimeric ligands (English)

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11 August 2017

Heather L Handl

1

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11 August 2017

Josef Vagner

2

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11 August 2017

Haiyong Han

3

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11 August 2017

Eugene Mash

4

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11 August 2017

Victor J Hruby

5

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11 August 2017

Robert J Gillies

6

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11 August 2017

language of work or name

English

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publication date

1 December 2004

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Expert Opinion on Therapeutic Targets

11 August 2017

published in

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11 August 2017

volume

8

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11 August 2017

issue

6

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11 August 2017

page(s)

565-586

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Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of alpha-MSH.

11 August 2017

cites work

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New protein engineering approaches to multivalent and bispecific antibody fragments

21 January 2018

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Design and application of diabodies, triabodies and tetrabodies for cancer targeting

21 January 2018

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Surface modification of liposomes for selective cell targeting in cardiovascular drug delivery

21 January 2018

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Peptide-targeted PEG-liposomes in anti-angiogenic therapy

21 January 2018

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A growth factor antagonist as a targeting agent for sterically stabilized liposomes in human small cell lung cancer

21 January 2018

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Tobacco mosaic virus as a carrier for small molecules: Artificial receptor antibodies and superhormones

21 January 2018

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Tobacco mosaic virus-enkephalin conjugates: potentiation of opioid activity

21 January 2018

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Stoichiometry of active smad-transcription factor complexes on DNA

21 January 2018

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Kinetic analysis of adenovirus fiber binding to its receptor reveals an avidity mechanism for trimeric receptor-ligand interactions.

21 January 2018

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Tuning chemotactic responses with synthetic multivalent ligands.

21 January 2018

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High-avidity, low-affinity multivalent interactions and the block to polyspermy in Xenopus laevis

21 January 2018

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Synthetic multivalent ligands in the exploration of cell-surface interactions

21 January 2018

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The cluster glycoside effect

21 January 2018

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Probing polyvalency in artificial systems exhibiting molecular recognition

21 January 2018

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Melanotropic peptide-conjugated beads for microscopic visualization and characterization of melanoma melanotropin receptors

21 January 2018

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1H nuclear-magnetic-resonance studies of the molecular conformation of monomeric glucagon in aqueous solution

21 January 2018

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The relation of polypeptide hormone structure and flexibility to receptor binding: The relevance of X-ray studies on insulins, glucagon and human placental lactogen

21 January 2018

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The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution

21 January 2018

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Nonstatistical binding of a protein to clustered carbohydrates

21 January 2018

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Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension

21 January 2018

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Measurement of the lateral mobility of cell surface components in single, living cells by fluorescence recovery after photobleaching

21 January 2018

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Compartmentalized structure of the plasma membrane for receptor movements as revealed by a nanometer-level motion analysis

21 January 2018

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DNA probes: applications of the principles of nucleic acid hybridization

21 January 2018

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Hybridization and renaturation kinetics of nucleic acids

21 January 2018

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Kinetics of renaturation of DNA

21 January 2018

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Kinetic studies by fluorescence resonance energy transfer employing a double-labeled oligonucleotide: hybridization to the oligonucleotide complement and to single-stranded DNA.

21 January 2018

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Multivalent inhibition of AB(5) toxins

21 January 2018

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On the attribution and additivity of binding energies

21 January 2018

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Additivity and the physical basis of multivalency effects: a thermodynamic investigation of the calcium EDTA interaction

21 January 2018

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Predicting DNA duplex stability from the base sequence

21 January 2018

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Her-2/neu and breast cancer

21 January 2018

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Bivalency as a principle for proteasome inhibition

21 January 2018

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Kinetics and thermodynamics of virus binding to receptor. Studies with rhinovirus, intercellular adhesion molecule-1 (ICAM-1), and surface plasmon resonance

21 January 2018

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Towards the development of antimicrobial drugs acting by inhibition of pathogen attachment to host cells: a need for polyvalency

21 January 2018

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Dimerization of sumatriptan as an efficient way to design a potent, centrally and orally active 5-HT1B agonist

21 January 2018

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Opioid agonist and antagonist bivalent ligands as receptor probes

21 January 2018

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Narcotic antagonistic potency of bivalent ligands which contain beta-naltrexamine. Evidence for bridging between proximal recognition sites

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.8.6.565

Synthesis and characterization of bivalent peptide ligands targeted to G-protein-coupled receptors

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.8.6.565

Opioid antagonist activity of naltrexone-derived bivalent ligands: importance of a properly oriented molecular scaffold to guide "address" recognition at kappa opioid receptors

21 January 2018

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New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity

21 January 2018

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Dimers of D-myo-inositol 1,4,5-trisphosphate: design, synthesis, and interaction with Ins(1,4,5)P3 receptors.

21 January 2018

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Interactions of inositol 1,4,5-trisphosphate (IP(3)) receptors with synthetic poly(ethylene glycol)-linked dimers of IP(3) suggest close spacing of the IP(3)-binding sites.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.8.6.565

Template assembled cyclopeptides as multimeric system for integrin targeting and endocytosis

21 January 2018

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Bolaforms with fourteen galactose units: a proposed site-directed cohesion of cancer cells

21 January 2018

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Bivalent inhibition of human beta-tryptase

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.8.6.565

Inhibition of cell adhesion to fibronectin by oligopeptide-substituted polynorbornenes

21 January 2018

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Novel class of bivalent glutathione S-transferase inhibitors

21 January 2018

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Dimerization of neurokinin A and B COOH-terminal heptapeptide fragments enhanced the selectivity for tachykinin receptor subtypes

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.8.6.565

Discovering high-affinity ligands for proteins: SAR by NMR

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.8.6.565

Chemically induced dimerization of dihydrofolate reductase by a homobifunctional dimer of methotrexate.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.8.6.565

Amino propynyl benzoic acid building block in rigid spacers of divalent ligands binding to the Syk SH2 domains with equally high affinity as the natural ligand

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.8.6.565

A novel multivalent human CTL peptide construct elicits robust cellular immune responses in HLA-A*0201 transgenic mice: implications for HTLV-1 vaccine design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.565

A new class of bradykinin antagonists: synthesis and in vitro activity of bissuccinimidoalkane peptide dimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.565

Highly Effective Poly(Ethylene Glycol) Architectures for Specific Inhibition of Immune Receptor Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.565

Influencing Receptor−Ligand Binding Mechanisms with Multivalent Ligand Architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.565

Control of Multivalent Interactions by Binding Epitope Density

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.565

Serotonin Dimers: Application of the Bivalent Ligand Approach to the Design of New Potent and Selective 5-HT1B/1DAgonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.565

Spanning binding sites on allosteric proteins with polymer-linked ligand dimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.565

Nanometre-level analysis demonstrates that lipid flow does not drive membrane glycoprotein movements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.565

21 January 2018

Identifiers

DOI

10.1517/14728222.8.6.565

1 reference

11 August 2017

1 reference