Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice (Q35982759)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22529362%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice (English)

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29 January 2020

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1

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29 January 2020

author name string

David E Housman

series ordinal

2

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29 January 2020

language of work or name

English

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publication date

23 April 2012

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Proceedings of the National Academy of Sciences of the United States of America

29 January 2020

number of pages

6

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based on heuristic

inferred from page(s)

published in

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29 January 2020

volume

109

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29 January 2020

issue

19

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29 January 2020

page(s)

7487-7492

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Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.

29 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

Huntington's disease: can mice lead the way to treatment?

2 October 2017

1 reference

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Longitudinal behavioral, cross-sectional transcriptional and histopathological characterization of a knock-in mouse model of Huntington's disease with 140 CAG repeats

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

The R6 lines of transgenic mice: a model for screening new therapies for Huntington's disease

2 October 2017

1 reference

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Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice

2 October 2017

1 reference

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Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington's disease.

2 October 2017

1 reference

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FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains

2 October 2017

1 reference

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The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies

2 October 2017

1 reference

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A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

2 October 2017

1 reference

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Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

siRNA-mediated gene silencing in vitro and in vivo.

2 October 2017

1 reference

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Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

Huntington's disease progression. PET and clinical observations.

2 October 2017

1 reference

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Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

Adenosine A2 receptors regulate the gene expression of striatopallidal and striatonigral neurons

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358846

24 September 2018

Identifiers

DOI

10.1073/PNAS.1204542109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22529362%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

0 references

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29 January 2020

PubMed publication ID

22529362

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22529362%20AND%20SRC:MED&resulttype=core&format=json