Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria (Q35991425)

From Wikidata

Jump to navigation Jump to search

scientific article

Language	Label	Description	Also known as
English	Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

0 references

Plasmodium falciparum

0 references

type II NADH:ubiquinone oxidoreductase

1 reference

11 September 2018

0 references

0 references

Janet Hemingway

25

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Giancarlo Biagini

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Sitthivut Charoensutthivarakul

18

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

23

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

24

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

26

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

29

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

30

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

32

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Ashley J Warman

8

object named as

Ashley J Warman

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

3

object named as

Alison E Shone

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Richard K Amewu

11

object named as

Richard K Amewu

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Chandrakala Pidathala

10

object named as

Chandrakala Pidathala

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Anne-Marie Zeeman

28

object named as

Anne-Marie Zeeman

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Alexandre S Lawrenson

17

object named as

Alexandre S Lawrenson

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Alison Mbekeani

21

object named as

Alison Mbekeani

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

12

object named as

Suet C Leung

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

22

object named as

Paul A Stocks

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Bénédicte Pacorel

16

object named as

Bénédicte Pacorel

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

20

object named as

Olivier Berger

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Robert E Sinden

27

object named as

Robert E Sinden

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

author name string

Nicholas Fisher

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Murad A Mubaraki

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Abhishek Srivastava

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Alisdair Hill

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Thomas Antoine

7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Jill Davies

9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Raman Sharma

13

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Peter Gibbons

14

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

David W Hong

15

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Lee Taylor

19

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Paul M O'Neill

31

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

language of work or name

0 references

publication date

7 May 2012

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

109

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

8298-8303

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

21

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

Inhibiting Plasmodium cytochrome bc1: a complex issue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

Current trends in ligand-based virtual screening: molecular representations, data mining methods, new application areas, and performance evaluation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

Chapter 17 Type II NADH: quinone oxidoreductases of Plasmodium falciparum and Mycobacterium tuberculosis kinetic and high-throughput assays.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

Network pharmacology: the next paradigm in drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

Similarity-based virtual screening using 2D fingerprints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

PowerMV: a software environment for molecular viewing, descriptor generation, data analysis and hit evaluation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

Reoptimization of MDL keys for use in drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

Drug-like properties and the causes of poor solubility and poor permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

Human malaria parasites in continuous culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

2 October 2017

Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

27 July 2018

Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

27 July 2018

Access to hematin: the basis of chloroquine resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

27 July 2018

Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361392

27 July 2018

Inhibition of pyrimidine biosynthesis de novo in Plasmodium falciparum by 2-(4-t-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone in vitro

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1205651109

21 January 2018

Plasmodium falciparum: the effects of atovaquone resistance on respiration.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1205651109

21 January 2018

Acidic acetonitrile for cellular metabolome extraction from Escherichia coli.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1205651109

21 January 2018

Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4'-chlorophenyl) cyclohexyl]-3- hydroxy-1,4-naphthoquinone (566C80)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22566611

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

dCTP levels are maintained in Plasmodium falciparum subjected to pyrimidine deficiency or excess

1 reference

https://pubmed.ncbi.nlm.nih.gov/22566611

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.1205651109

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

2012PNAS..109.8298B

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22566611%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q35991425&oldid=1959300589"