Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities. (Q35992635)

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2 February 2020

title

Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities (English)

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1

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Pauli Kallio

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2 February 2020

Mikko Metsä-Ketelä

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author name string

Keqiang Fan

3

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2 February 2020

Karel D Klika

4

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Khaled A Shaaban

5

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2 February 2020

Pekka Mäntsälä

6

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Jürgen Rohr

7

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Keqian Yang

8

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Jarmo Niemi

9

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publication date

1 May 2012

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2 February 2020

published in

Chemistry and Biology

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volume

19

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issue

5

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page(s)

647-655

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Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis

2 February 2020

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2 October 2017

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Functional analyses of oxygenases in jadomycin biosynthesis and identification of JadH as a bifunctional oxygenase/dehydrase

2 October 2017

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Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycin

2 October 2017

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Enzymes with extra talents: moonlighting functions and catalytic promiscuity

2 October 2017

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Engineering anthracycline biosynthesis toward angucyclines

2 October 2017

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Coenzyme-based functional assignments of short-chain dehydrogenases/reductases (SDRs).

2 October 2017

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Modification of post-PKS tailoring steps through combinatorial biosynthesis

2 October 2017

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Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tü2717.

2 October 2017

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Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis

2 October 2017

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2 October 2017

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Cloning and characterization of a polyketide synthase gene from Streptomyces fradiae Tü2717, which carries the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation

2 October 2017

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2 October 2017

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14 November 2018

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12 December 2020

Flavoprotein hydroxylase PgaE catalyzes two consecutive oxygen-dependent tailoring reactions in angucycline biosynthesis

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12 December 2020

Determination of absolute configuration using optical rotation calculated using density functional theory

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12 December 2020

Artificial Reconstruction of Two Cryptic Angucycline Antibiotic Biosynthetic Pathways

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12 December 2020

10.1016/J.CHEMBIOL.2012.04.010

Identifiers

DOI

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PubMed publication ID

22633416

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