NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets (Q35992694)

11 August 2017

NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets (English)

1 reference

11 August 2017

0 references

congenital heart disease

1 reference

Romaric Bouveret

1

0 references

Ashley J Waardenberg

Ashley J Waardenberg

2

0 references

Chiann-Mun Chen

Chiann-Mun Chen

11

0 references

Gavin Chapman

Gavin Chapman

16

0 references

Mirana Ramialison

Mirana Ramialison

4

0 references

Merridee A. Wouters

Merridee A Wouters

12

0 references

Sally L. Dunwoodie

Sally L Dunwoodie

15

0 references

Shoumo Bhattacharya

Shoumo Bhattacharya

13

0 references

Richard P. Harvey

Richard P Harvey

18

0 references

Cédric Blanpain

17

Cédric Blanpain

1 reference

11 August 2017

Nicole Schonrock

3

1 reference

11 August 2017

Tram Doan

5

1 reference

11 August 2017

Danielle de Jong

6

1 reference

11 August 2017

Antoine Bondue

7

1 reference

11 August 2017

Gurpreet Kaur

8

1 reference

11 August 2017

Stephanie Mohamed

9

1 reference

11 August 2017

Hananeh Fonoudi

10

1 reference

11 August 2017

Nicolas Plachta

14

1 reference

11 August 2017

language of work or name

English

0 references

publication date

6 July 2015

1 reference

11 August 2017

1 reference

11 August 2017

4

1 reference

describes a project that uses

11 August 2017

Cytoscape

Cytoscape

2 references

9 June 2022

https://europepmc.org/search?query=(METHODS:'Cytoscape')

inferred from PubMed Central ID database lookup

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

affy

affy

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

cites work

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Highly expressed loci are vulnerable to misleading ChIP localization of multiple unrelated proteins

2 October 2017

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Genome-wide screens for in vivo Tinman binding sites identify cardiac enhancers with diverse functional architectures

2 October 2017

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Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium.

2 October 2017

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Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer

2 October 2017

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Initial deployment of the cardiogenic gene regulatory network in the basal chordate, Ciona intestinalis

2 October 2017

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A high-resolution whole-genome map of key chromatin modifications in the adult Drosophila melanogaster

2 October 2017

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Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function

2 October 2017

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ETS-dependent regulation of a distal Gata4 cardiac enhancer

2 October 2017

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Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5

2 October 2017

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Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm

2 October 2017

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Genomic and biochemical insights into the specificity of ETS transcription factors

2 October 2017

1 reference

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Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart.

2 October 2017

1 reference

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Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation

2 October 2017

1 reference

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The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

The insulator protein SU(HW) fine-tunes nuclear lamina interactions of the Drosophila genome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Stem Cells and Their Derivatives: A Renaissance in Cardiovascular Translational Research

2 October 2017

1 reference

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Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors

2 October 2017

1 reference

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ChIP on Chip: surprising results are often artifacts.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

GREAT improves functional interpretation of cis-regulatory regions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Starr: Simple Tiling ARRay analysis of Affymetrix ChIP-chip data

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

BEDTools: a flexible suite of utilities for comparing genomic features

2 October 2017

1 reference

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Genome-wide discovery of human heart enhancers

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Overlapping promoter targeting by Elk-1 and other divergent ETS-domain transcription factor family members

2 October 2017

1 reference

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Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery

2 October 2017

1 reference

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Transcriptional remodeling of rapidly stimulated HL-1 atrial myocytes exhibits concordance with human atrial fibrillation

2 October 2017

1 reference

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NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Diversity and complexity in DNA recognition by transcription factors

2 October 2017

1 reference

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

2 October 2017

1 reference

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An integrated software system for analyzing ChIP-chip and ChIP-seq data

2 October 2017

1 reference

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BioVenn - a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams

2 October 2017

1 reference

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Visualization, documentation, analysis, and communication of large-scale gene regulatory networks

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

JASPAR, the open access database of transcription factor-binding profiles: new content and tools in the 2008 update

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Characterization of spectral FRET imaging microscopy for monitoring nuclear protein interactions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Detection of in vivo protein-DNA interactions using DamID in mammalian cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Human heterochromatin proteins form large domains containing KRAB-ZNF genes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

FGF signaling delineates the cardiac progenitor field in the simple chordate, Ciona intestinalis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Hotspots of transcription factor colocalization in the genome of Drosophila melanogaster

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Erm/thyroid transcription factor 1 interactions modulate surfactant protein C transcription

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Chromosomal distribution of PcG proteins during Drosophila development

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

p204 protein overcomes the inhibition of the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes by Id proteins.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Gene regulatory networks and the evolution of animal body plans

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

TileMap: create chromosomal map of tiling array hybridizations

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Foxh1 is essential for development of the anterior heart field

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Detection of functional DNA motifs via statistical over-representation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

affy--analysis of Affymetrix GeneChip data at the probe level

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Nuclear factor I/thyroid transcription factor 1 interactions modulate surfactant protein C transcription

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Novel point mutation in the cardiac transcription factor CSX/NKX2.5 associated with congenital heart disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

The human genome browser at UCSC

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Chromatin profiling using targeted DNA adenine methyltransferase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Identification of in vivo DNA targets of chromatin proteins using tethered dam methyltransferase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tisue-specifying homeobox gene product Csx/Nkx2.5

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

A third-generation lentivirus vector with a conditional packaging system

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Ternary complex factors: growth factor regulated transcriptional activators

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Combinatorial function of ETS transcription factors in the developing vasculature

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Biochemical analyses of eight NKX2.5 homeodomain missense mutations causing atrioventricular block and cardiac anomalies

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Probing transcription factor diffusion dynamics in the living mammalian embryo with photoactivatable fluorescence correlation spectroscopy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Using Trawler_standalone to discover overrepresented motifs in DNA and RNA sequences derived from various experiments including chromatin immunoprecipitation.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Using Weeder for the discovery of conserved transcription factor binding sites.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

A TAT-DEF-Elk-1 peptide regulates the cytonuclear trafficking of Elk-1 and controls cytoskeleton dynamics.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Site-directed mutations in the vnd/NK-2 homeodomain. Basis of variations in structure and sequence-specific DNA binding.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Competition between negative acting YY1 versus positive acting serum response factor and tinman homologue Nkx-2.5 regulates cardiac alpha-actin promoter activity.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548209

Progressive AV-block and anomalous venous return among cardiac anomalies associated with two novel missense mutations in the CSX/NKX2-5 gene

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26146939

12 December 2020

inferred from PubMed ID database lookup

Cytoscape: a community-based framework for network modeling

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26146939

12 December 2020

inferred from PubMed ID database lookup

Interaction of transcription factors with serum response factor. Identification of the Elk-1 binding surface

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26146939

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.7554/ELIFE.06942

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

26146939

1 reference