Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults. (Q35993635)

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English	Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults.	scientific article

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23 January 2020

Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults (English)

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23 January 2020

Melissa M Markofski

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23 January 2020

Douglas Paddon-Jones

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23 January 2020

Blake B. Rasmussen

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23 January 2020

Micah J Drummond

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Micah J Drummond

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23 January 2020

Kyle L Timmerman

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Kyle L Timmerman

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23 January 2020

Christopher S Fry

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Christopher S Fry

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23 January 2020

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Paul T Reidy

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23 January 2020

author name string

Jared M Dickinson

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23 January 2020

Dillon K Walker

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23 January 2020

David M Gundermann

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23 January 2020

publication date

14 February 2012

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23 January 2020

American Journal of Physiology - Endocrinology and Metabolism

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23 January 2020

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23 January 2020

E1113-22

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23 January 2020

SNAT2 transceptor signalling via mTOR: a role in cell growth and proliferation?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

Early ambulation and length of stay in older adults hospitalized for acute illness

1 reference

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2 October 2017

Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women

1 reference

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2 October 2017

Forty-eight hours of unloading and 24 h of reloading lead to changes in global gene expression patterns related to ubiquitination and oxidative stress in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

Bidirectional transport of amino acids regulates mTOR and autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

Skeletal muscle proteolysis in response to short-term unloading in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

Insulin signaling and the general amino acid control response. Two distinct pathways to amino acid synthesis and uptake.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

Nutrient signalling in the regulation of human muscle protein synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

Ceramide down-regulates System A amino acid transport and protein synthesis in rat skeletal muscle cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise

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2 October 2017

The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

Insulin promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

Prolonged bed rest decreases skeletal muscle and whole body protein synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

2 October 2017

Enhanced amino acid sensitivity of myofibrillar protein synthesis persists for up to 24 h after resistance exercise in young men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

23 September 2018

Effects of aging on muscle mechanical function and muscle fiber morphology during short-term immobilization and subsequent retraining

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

23 September 2018

Effects of 3 days unloading on molecular regulators of muscle size in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

23 September 2018

Little change in markers of protein breakdown and oxidative stress in humans in immobilization-induced skeletal muscle atrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

23 September 2018

Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

23 September 2018

Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

23 September 2018

Regulation of placental amino acid transporter activity by mammalian target of rapamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

23 September 2018

Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

23 September 2018

Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

23 September 2018

A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

23 September 2018

L-leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-re

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

23 September 2018

The determination of low d5-phenylalanine enrichment (0.002-0.09 atom percent excess), after conversion to phenylethylamine, in relation to protein turnover studies by gass chromatography/electron ionization mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3361979

23 September 2018

Effects of aging on human skeletal muscle after immobilization and retraining

1 reference

https://pubmed.ncbi.nlm.nih.gov/22338078

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deleterious effects of bed rest among community-living older persons

1 reference

https://pubmed.ncbi.nlm.nih.gov/22338078

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/22338078

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decrease in human quadriceps muscle protein turnover consequent upon leg immobilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/22338078

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in lower limb muscle cross-sectional area and tissue fluid volume after transition from standing to supine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22338078

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/22338078

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Using step activity monitoring to characterize ambulatory activity in community-dwelling older adults

1 reference

https://pubmed.ncbi.nlm.nih.gov/22338078

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of 10 days of bed rest on skeletal muscle in healthy older adults

1 reference

https://pubmed.ncbi.nlm.nih.gov/22338078

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the transcription factor ATF4 in the anabolic actions of insulin and the anti-anabolic actions of glucocorticoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/22338078

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging does not impair the anabolic response to a protein-rich meal

1 reference

https://pubmed.ncbi.nlm.nih.gov/22338078

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1152/AJPENDO.00603.2011

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23 January 2020

1 reference

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23 January 2020

1 reference

Europe PubMed Central

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23 January 2020

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