A thrombin-cross-reactive anticardiolipin antibody binds to and inhibits the anticoagulant function of activated protein C. (Q35995065)

11 August 2017

A thrombin-cross-reactive anticardiolipin antibody binds to and inhibits the anticoagulant function of activated protein C. (English)

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11 August 2017

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Kwan-Ki Hwang

1

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11 August 2017

Cheng-De Yang

2

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11 August 2017

Weihong Yan

3

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11 August 2017

Jennifer M Grossman

4

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11 August 2017

Bevra H Hahn

5

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11 August 2017

Pojen P Chen

6

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11 August 2017

1 June 2003

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11 August 2017

Arthritis & Rheumatology

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11 August 2017

48

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11 August 2017

6

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11 August 2017

1622-1630

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Regulation of blood coagulation

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein C activation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

Thrombosis in primary antiphospholipid syndrome: a pivotal role for monocyte tissue factor expression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

The 2.8 A crystal structure of Gla-domainless activated protein C

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

Mutation in blood coagulation factor V associated with resistance to activated protein C.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

Induction of tissue factor-like activity in monocytes by anti-cardiolipin antibodies.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

On the role of phosphatidylethanolamine in the inhibition of activated protein C activity by antiphospholipid antibodies

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

Activation of cultured vascular endothelial cells by antiphospholipid antibodies.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

A comprehensive set of sequence analysis programs for the VAX

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

Anti-prothrombin antibodies and the lupus anticoagulant

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H)

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

An IgG antiprothrombin antibody enhances prothrombin binding to damaged endothelial cells and shortens plasma coagulation times

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

Binding of anticardiolipin antibodies to protein C via beta2-glycoprotein I (beta2-GPI): a possible mechanism in the inhibitory effect of antiphospholipid antibodies on the protein C system

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

Characterization of IgG monoclonal anti-cardiolipin/anti-beta2GP1 antibodies from two patients with antiphospholipid syndrome reveals three species of antibodies

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

Functional requirements for inhibition of thrombin by antithrombin III in the presence and absence of heparin

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1978198

Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor

23 September 2018

1 reference

12 December 2020

Inhibition of activated protein C and its cofactor protein S by antiphospholipid antibodies

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12 December 2020

Lupus anticoagulant IgG's (LA) are not directed to phospholipids only, but to a complex of lipid-bound human prothrombin

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12 December 2020

Immunoglobulin fractions isolated from patients with antiphospholipid antibodies prevent the inactivation of factor Va by activated protein C on human endothelial cells

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12 December 2020

Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C, or protein S: an explanation for their pathogenic mechanism?

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12 December 2020

Anticoagulant protein C pathway defective in majority of thrombophilic patients

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12 December 2020

Endothelial cells as target for antiphospholipid antibodies. Human Polyclonal and Monoclonal Anti-β2-Glycoprotein I Antibodies React In Vitro with Endothelial Cells Through Adherent β2-Glycoprotein I and Induce Endothelial Activation

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12 December 2020

Extensive venous and arterial thrombosis associated with an inhibitor to activated protein C

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12 December 2020

A fatal thrombotic disorder associated with an acquired inhibitor of protein C

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12 December 2020

Measurements of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunosorbent assay

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12 December 2020

Three-dimensional modeling of thrombin-fibrinogen interaction

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12 December 2020

Identification of anti-thrombin antibodies in the antiphospholipid syndrome that interfere with the inactivation of thrombin by antithrombin

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12 December 2020

Functional analyses of patient-derived IgG monoclonal anticardiolipin antibodies using in vivo thrombosis and in vivo microcirculation models

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12 December 2020

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12 December 2020

Inhibition of activated protein C anticoagulant activity by prothrombin

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12 December 2020

Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease

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12 December 2020

Effect of lupus anticoagulant on antithrombogenic properties of endothelial cells--inhibition of thrombomodulin-dependent protein C activation

1 reference

12 December 2020

Impaired catalytic function of activated protein C: a new in vitro manifestation of lupus anticoagulant

1 reference

12 December 2020

Identifiers

DOI

10.1002/ART.10983

1 reference

11 August 2017

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11 August 2017

PubMed publication ID

12794830

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