Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion (Q36002013)

11 August 2017

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion (English)

1 reference

11 August 2017

Miguel Ganuza

1

0 references

Gonzalo Gómez-López

object named as

Gonzalo Gómez

4

0 references

David G. Pisano

object named as

David Pisano

7

0 references

Maria A Blasco

object named as

María A Blasco

6

0 references

author name string

Cristina Sáiz-Ladera

2

1 reference

11 August 2017

Marta Cañamero

3

1 reference

11 August 2017

Ralph Schneider

5

1 reference

11 August 2017

Jesús M Paramio

8

1 reference

11 August 2017

David Santamaría

9

1 reference

11 August 2017

Mariano Barbacid

10

1 reference

11 August 2017

language of work or name

English

0 references

publication date

13 April 2012

1 reference

11 August 2017

1 reference

11 August 2017

31

1 reference

11 August 2017

11

1 reference

11 August 2017

2498-2510

1 reference

describes a project that uses

11 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3365431/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/3365431

based on heuristic

inferred from PubMed Central ID database lookup

cites work

The role of telomeres and telomerase in stem cell aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

The longest telomeres: a general signature of adult stem cell compartments

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

High-throughput telomere length quantification by FISH and its application to human population studies

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

Secrets of a double agent: CDK7 in cell-cycle control and transcription

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

Mammalian cyclin-dependent kinases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

Genomewide production of multipurpose alleles for the functional analysis of the mouse genome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

E2F target genes: unraveling the biology

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

Cdk2 knockout mice are viable

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

Investigating RNA polymerase II carboxyl-terminal domain (CTD) phosphorylation.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

Human housekeeping genes are compact

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

cdk-7 Is required for mRNA transcription and cell cycle progression in Caenorhabditis elegans embryos

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

Cdk1 is sufficient to drive the mammalian cell cycle

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

The role of Cdk7 in CAK function, a retro-retrospective

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365431

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

27 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.94

Conditional ablation of the Mat1 subunit of TFIIH in Schwann cells provides evidence that Mat1 is not required for general transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.94

Stem cells and the rate of living

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.94

Impairment of the TFIIH-associated CDK-activating kinase selectively affects cell cycle-regulated gene expression in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.94

Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.94

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.94

Use of within-array replicate spots for assessing differential expression in microarray experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.94

Delayed ageing through damage protection by the Arf/p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.94

Pathology of aging B6;129 mice

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22505032

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2012.94

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

22505032

1 reference