Cell entry and export of nucleoside analogues (Q36008876)

11 August 2017

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title

Cell entry and export of nucleoside analogues (English)

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11 August 2017

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Marçal Pastor-Anglada

1

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11 August 2017

Pedro Cano-Soldado

2

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11 August 2017

Míriam Molina-Arcas

3

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11 August 2017

M Pilar Lostao

4

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11 August 2017

Ignacio Larráyoz

5

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11 August 2017

Javier Martínez-Picado

6

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11 August 2017

F Javier Casado

7

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11 August 2017

1 February 2005

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11 August 2017

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11 August 2017

107

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11 August 2017

2

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11 August 2017

151-164

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Therapeutic and biological importance of getting nucleotides out of cells: a case for the ABC transporters, MRP4 and 5.

11 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Regulation of expression of the intestinal oligopeptide transporter (Pept-1) in health and disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Curing of foot-and-mouth disease virus from persistently infected cells by ribavirin involves enhanced mutagenesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Inhibition of intestinal dipeptide transport by the neuropeptide VIP is an anti-absorptive effect via the VPAC1 receptor in a human enterocyte-like cell line (Caco-2).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

How to Make Drugs Orally Active: A Substrate Template for Peptide Transporter PepT1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

The equilibrative nucleoside transporter family, SLC29

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Nucleoside transporters: molecular biology and implications for therapeutic development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, beta-lactam antibiotics and ACE-inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Structure and function of efflux pumps that confer resistance to drugs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Mammalian ABC transporters in health and disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Phylogenetic and functional classification of ATP-binding cassette (ABC) systems

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Functional expression of human intestinal Na+-dependent and Na+-independent nucleoside transporters in Xenopus laevis oocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na(+)-nucleoside cotransporter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Role of organic cation transporters in the renal secretion of nucleosides.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

RNA virus error catastrophe: direct molecular test by using ribavirin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Developmental regulation of the concentrative nucleoside transporters CNT1 and CNT2 in rat liver.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Differential expression and regulation of nucleoside transport systems in rat liver parenchymal and hepatoma cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Minimal molecular determinants of substrates for recognition by the intestinal peptide transporter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Selective loss of nucleoside carrier expression in rat hepatocarcinomas.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

ATP-sensitive K(+) channels regulate the concentrative adenosine transporter CNT2 following activation by A(1) adenosine receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Error catastrophe and antiviral strategy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Expression cloning of a mammalian proton-coupled oligopeptide transporter.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Na+-dependent nucleoside transport in liver: two different isoforms from the same gene family are expressed in liver cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Up-regulation of the high-affinity pyrimidine-preferring nucleoside transporter concentrative nucleoside transporter 1 by tumor necrosis factor-alpha and interleukin-6 in liver parenchymal cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Synthesis of analogs of L-valacyclovir and determination of their substrate activity for the oligopeptide transporter in Caco-2 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

The concentrative nucleoside transporter family, SLC28

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

The kinetics of uptake of 5-fluorouracil by rat liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Ribavirin uptake by human erythrocytes and the involvement of nitrobenzylthioinosine-sensitive (es)-nucleoside transporters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Intestinal absorption of drugs mediated by drug transporters: mechanisms and regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

The SLC22 drug transporter family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

The MRP family of drug efflux pumps

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Gene Expression in the Human Intestine and Correlation with Oral Valacyclovir Pharmacokinetic Parameters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Acquisition of human concentrative nucleoside transporter 2 (hcnt2) activity by gene transfer confers sensitivity to fluoropyrimidine nucleosides in drug-resistant leukemia cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Electrophysiological characterization of the human Na(+)/nucleoside cotransporter 1 (hCNT1) and role of adenosine on hCNT1 function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Lethal mutagenesis of HIV with mutagenic nucleoside analogs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Lethal mutagenesis of HIV by mutagenic ribonucleoside analogs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Electrogenic uptake of nucleosides and nucleoside-derived drugs by the human nucleoside transporter 1 (hCNT1) expressed in Xenopus laevis oocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

3'-Azido-3'-deoxythymidine (AZT) and AZT-resistant reverse transcriptase can increase the in vivo mutation rate of human immunodeficiency virus type 1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Di/tri-peptide transporters as drug delivery targets: regulation of transport under physiological and patho-physiological conditions.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Influence of pH on the uptake of 5-fluorouracil into isolated tumour cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Mutagenesis versus Inhibition in the Efficiency of Extinction of Foot-and-Mouth Disease Virus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Efficient Virus Extinction by Combinations of a Mutagen and Antiviral Inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Complex regulation of nucleoside transporter expression in epithelial and immune system cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Transport and mode of action of nucleoside derivatives used in chemical and antiviral therapies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Nucleoside transporters in chronic lymphocytic leukaemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Intestinal absorption of ribavirin is preferentially mediated by the Na+-nucleoside purine (N1) transporter.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Differential expression of human nucleoside transporters in normal and tumor tissue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Modulation of the equilibrative nucleoside transporter by inhibitors of DNA synthesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Effects of glibenclamide on glycylsarcosine transport by the rat peptide transporters PEPT1 and PEPT2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

The organic cation transporters rOCT1 and hOCT2 are inhibited by cGMP.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

The multispecific organic anion transporter (OAT) family.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Expression cloning and characterization of a novel multispecific organic anion transporter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Cellular and molecular mechanisms of dietary regulation on rat intestinal H+/Peptide transporter PepT1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Interferon-gamma regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathways.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Macrophages require different nucleoside transport systems for proliferation and activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Lipopolysaccharide-induced apoptosis of macrophages determines the up-regulation of concentrative nucleoside transporters Cnt1 and Cnt2 through tumor necrosis factor-alpha-dependent and -independent mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Lack of evidence for proofreading mechanisms associated with an RNA virus polymerase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Human organic anion transporters and human organic cation transporters mediate renal antiviral transport

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Regulation of the PepT1 peptide transporter in the rat small intestine in response to 5-fluorouracil-induced injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Structural requirements for determining the substrate affinity of peptide transporters PEPT1 and PEPT2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Functional and molecular expression of intestinal oligopeptide transporter (Pept-1) after a brief fast.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

H/dipeptide absorption across the human intestinal epithelium is controlled indirectly via a functional Na/H exchanger.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Cell-cycle-dependent regulation of CNT1, a concentrative nucleoside transporter involved in the uptake of cell-cycle-dependent nucleoside-derived anticancer drugs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Nutritional regulation of nucleoside transporter expression in rat small intestine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Molecular pharmacology of renal organic anion transporters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Substrate upregulation of the human small intestinal peptide transporter, hPepT1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. Ent2 exhibits a low affinity for guanosine and cytidine but a high affinity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Feedback inhibition of amidophosphoribosyltransferase regulates the rate of cell growth via purine nucleotide, DNA, and protein syntheses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Transport of antiviral 3'-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Uridine binding motifs of human concentrative nucleoside transporters 1 and 3 produced in Saccharomyces cerevisiae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

Mutation Frequencies at Defined Single Codon Sites in Vesicular Stomatitis Virus and Poliovirus Can Be Increased Only Slightly by Chemical Mutagenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIRUSRES.2004.11.005

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7 January 2021

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DOI

10.1016/J.VIRUSRES.2004.11.005

1 reference

11 August 2017

1 reference