The chemistry and biology of nitroxide compounds (Q36009998)

11 August 2017

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title

The chemistry and biology of nitroxide compounds (English)

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11 August 2017

Benjamin P Soule

1

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11 August 2017

Fuminori Hyodo

2

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11 August 2017

Ken-Ichiro Matsumoto

3

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11 August 2017

Nicole L Simone

4

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11 August 2017

John A Cook

5

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11 August 2017

Murali C Krishna

6

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11 August 2017

James B Mitchell

7

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11 August 2017

12 March 2007

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Free Radical Biology and Medicine

11 August 2017

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11 August 2017

42

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11 August 2017

11

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11 August 2017

1632-1650

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Dramatic extension of tumor latency and correction of neurobehavioral phenotype in Atm-mutant mice with a nitroxide antioxidant

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Nitroxide TEMPOL impairs mitochondrial function and induces apoptosis in HL60 cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Cellular sites of H2O2-induced damage and their protection by nitroxides

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

The nitroxide tempol induces oxidative stress, p21(WAF1/CIP1), and cell death in HL60 cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Neuroprotection by the stable nitroxide Tempol during reperfusion in a rat model of transient focal ischemia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Tempol reduces infarct size in rodent models of regional myocardial ischemia and reperfusion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Pathophysiology of Parkinson's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Hypothesis: can N-acetylcysteine be beneficial in Parkinson's disease?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: possible mechanisms of formation involving reactive oxygen species.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Studies of structure-activity relationship of nitroxide free radicals and their precursors as modifiers against oxidative damage

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Antiproliferative effect of the piperidine nitroxide TEMPOL on neoplastic and nonneoplastic mammalian cell lines

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

On a novel MRI technique (OMRI) for the determination of tissue parameters.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Stimulation by nitroxides of catalase-like activity of hemeproteins. Kinetics and mechanism

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Protective effect of 4-hydroxy-TEMPO, a low molecular weight superoxide dismutase mimic, on free radical toxicity in experimental pancreatitis.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Lithium phthalocyanine: a probe for electron paramagnetic resonance oximetry in viable biological systems

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Three-dimensional spectral-spatial EPR imaging of free radicals in the heart: a technique for imaging tissue metabolism and oxygenation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Work in progress: methods of contrast enhancement for NMR imaging and potential applications. A subject review

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

A novel metal-free low molecular weight superoxide dismutase mimic.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Principles of the metabolism of nitroxides and their implications for spin trapping

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Cardiac reperfusion damage prevented by a nitroxide free radical

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Low levels of glutathione peroxidase 1 activity in selenium-deficient mouse liver affect c-Jun N-terminal kinase activation and p53 phosphorylation on Ser-15 in pro-oxidant-induced aponecrosis.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Brain nuclear magnetic resonance imaging enhanced by a paramagnetic nitroxide contrast agent: preliminary report.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Feasibility study of imaging a living murine tumor by electron paramagnetic resonance

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Superoxide reaction with nitroxides

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Nitroxide SOD-mimics: modes of action

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Topical application of nitroxide protects radiation-induced alopecia in guinea pigs

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Nitroxide-mediated protection against X-ray- and neocarzinostatin-induced DNA damage

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Antimutagenicity of a low molecular weight superoxide dismutase mimic against oxidative mutagens

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Acute antihypertensive action of nitroxides in the spontaneously hypertensive rat.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

The effects of antioxidants on radiation-induced apoptosis pathways in TK6 cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

In vivo measurement of redox status in streptozotocin-induced diabetic rat using targeted nitroxyl probes

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

The stable nitroxide tempol facilitates salivary gland protection during head and neck irradiation in a mouse model

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Tempol-H inhibits opacification of lenses in organ culture

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Tempol, a novel stable nitroxide, reduces brain damage and free radical production, after acute subdural hematoma in the rat.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Stable nitroxide Tempol ameliorates brain injury by inhibiting lipid peroxidation in a rat model of transient focal cerebral ischemia

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Reaction of cyclic nitroxides with nitrogen dioxide: the intermediacy of the oxoammonium cations

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Study of in vitro and in vivo effects of the piperidine nitroxide Tempol--a potential new therapeutic agent for gliomas.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

A low molecular weight antioxidant decreases weight and lowers tumor incidence

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Changes in oxygenation of intracranial tumors with carbogen: a BOLD MRI and EPR oximetry study.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Feasibility and assessment of non-invasive in vivo redox status using electron paramagnetic resonance imaging

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

A naphthalocyanine-based EPR probe for localized measurements of tissue oxygenation.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Tempol, a membrane-permeable radical scavenger, reduces dinitrobenzene sulfonic acid-induced colitis.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Hemodynamic effect of the nitroxide superoxide dismutase mimics.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Decline in the expression of copper/zinc superoxide dismutase in the kidney of rats with endotoxic shock: effects of the superoxide anion radical scavenger, tempol, on organ injury

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Nitroxides increase the detectable amount of nitric oxide released from endothelial cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

DNA repair by thiols in air shows two radicals make a double-strand break

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Identification of nitroxide radioprotectors

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1991293

Nitroxide-doped liposomes containing entrapped oxidant: an approach to the "reduction problem" of nitroxides as MRI contrast agents

23 September 2018

1 reference

12 December 2020

Caloric restriction and aging

1 reference

12 December 2020

Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat

1 reference

12 December 2020

In vivo radioprotection and effects on blood pressure of the stable free radical nitroxides

1 reference

12 December 2020

Protection from lethal irradiation by the combination of stem cell factor and tempol

1 reference

12 December 2020

The effect of oxygen at physiological levels on the detection of free radical intermediates by electron paramagnetic resonance

1 reference

12 December 2020

Stable nitroxide radicals protect lipid acyl chains from radiation damage

1 reference

12 December 2020

Beneficial effects of tempol, a membrane-permeable radical scavenger, in a rodent model of collagen-induced arthritis

1 reference

12 December 2020

High-resolution mapping of tumor redox status by magnetic resonance imaging using nitroxides as redox-sensitive contrast agents

1 reference

12 December 2020

Evaluation of tempol radioprotection in a murine tumor model

1 reference

12 December 2020

Cytotoxicity of commonly used nitroxide radical spin probes

1 reference

12 December 2020

Nitroxide stable radical suppresses autoimmune uveitis in rats

1 reference

12 December 2020

THE EFFECT OF RETARDATION OF GROWTH UPON THE BREEDING PERIOD AND DURATION OF LIFE OF RATS

1 reference

12 December 2020

Effects of tempol, a membrane-permeable radical scavenger, in a rodent model of carrageenan-induced pleurisy

1 reference

12 December 2020

Synthesis and ESR studies of a novel cyclic nitrone spin trap attached to a phosphonium group-a suitable trap for mitochondria-generated ROS?

1 reference

12 December 2020

A new nitroxyl-probe with high retention in the brain and its application for brain imaging

1 reference

12 December 2020

Protection from oxidative insult in glutathione depleted lens epithelial cells

1 reference

12 December 2020

Biologically active metal-independent superoxide dismutase mimics

1 reference

12 December 2020

Tempol, a stable free radical, is a novel murine radiation protector

1 reference

12 December 2020

Work in progress: nuclear magnetic resonance study of a paramagnetic nitroxide contrast agent for enhancement of renal structures in experimental animals

1 reference

12 December 2020

Evaluation of the hydroxylamine Tempol-H as an in vivo radioprotector

1 reference

12 December 2020

Effects of tempol, a membrane-permeable radical scavenger, in a gerbil model of brain injury

1 reference

12 December 2020

A membrane-permeable radical scavenger reduces the organ injury in hemorrhagic shock

1 reference

12 December 2020

Hypoxia-sensitive NMR contrast agents

1 reference

12 December 2020

Amyloid beta peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides

1 reference

12 December 2020

Protection from radiation-induced chromosomal aberrations by the nitroxide Tempol

1 reference

12 December 2020

Antioxidant activity of nitroxide radicals in lipid peroxidation of rat liver microsomes

1 reference

12 December 2020

Hydrogen peroxide and human cataract

1 reference

12 December 2020

Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents

1 reference

12 December 2020

Do nitroxide antioxidants act as scavengers of O2-. or as SOD mimics?

1 reference

12 December 2020

Two-week administration of tempol attenuates both hypertension and renal excretion of 8-Iso prostaglandin f2alpha

1 reference

12 December 2020

In vivo electron paramagnetic resonance imaging of tumor heterogeneity and oxygenation in a murine model

1 reference

12 December 2020

The superoxide dismutase mimic TEMPOL protects cultured rabbit lens epithelial cells from hydrogen peroxide insult

1 reference

12 December 2020

10.1016/J.FREERADBIOMED.2007.02.030

Identifiers

DOI

1 reference

11 August 2017

1 reference

11 August 2017

1 reference