An effective second-generation outer surface protein A-derived Lyme vaccine that eliminates a potentially autoreactive T cell epitope (Q36017879)

11 August 2017

An effective second-generation outer surface protein A-derived Lyme vaccine that eliminates a potentially autoreactive T cell epitope (English)

1 reference

11 August 2017

0 references

Theresa A Willett

1

1 reference

11 August 2017

Abbie L Meyer

series ordinal

2

1 reference

11 August 2017

Eric L Brown

series ordinal

3

1 reference

11 August 2017

Brigitte T Huber

series ordinal

4

1 reference

11 August 2017

language of work or name

English

0 references

publication date

23 January 2004

1 reference

Proceedings of the National Academy of Sciences of the United States of America

11 August 2017

1 reference

11 August 2017

101

1 reference

11 August 2017

5

1 reference

11 August 2017

1303-1308

1 reference

Molecular adaptation of Borrelia burgdorferi in the murine host

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Approaches toward the directed design of a vaccine against Borrelia burgdorferi

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Two Controlled Trials of Antibiotic Treatment in Patients with Persistent Symptoms and a History of Lyme Disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Safety and immunogenicity of a recombinant Borrelia burgdorferi outer surface protein A vaccine against lyme disease in healthy children and adolescents: a randomized controlled trial

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Autoimmune mechanisms in antibiotic treatment-resistant lyme arthritis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Resistance to Lyme disease in decorin-deficient mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

VraA (BBI16) protein of Borrelia burgdorferi is a surface-exposed antigen with a repetitive motif that confers partial protection against experimental Lyme borreliosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Evidence for vaccine synergy between Borrelia burgdorferi decorin binding protein A and outer surface protein A in the mouse model of lyme borreliosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Borrelia burgdorferi gene expression in vivo and spirochete pathogenicity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Rapid and sensitive quantification of Borrelia burgdorferi-infected mouse tissues by continuous fluorescent monitoring of PCR.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Active and passive immunity against Borrelia burgdorferi decorin binding protein A (DbpA) protects against infection

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Therapeutic passive vaccination against chronic Lyme disease in mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Reactivity with a specific epitope of outer surface protein A predicts protection from infection with the Lyme disease spirochete, Borrelia burgdorferi

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Experimental immunization against Lyme borreliosis with recombinant Osp proteins: an overview

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Early and late antibody responses to full-length and truncated constructs of outer surface protein A of Borrelia burgdorferi in Lyme disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

A monoclonal antibody to OspA inhibits association of Borrelia burgdorferi with human endothelial cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Association between different clinical manifestations of Lyme disease and different species of Borrelia burgdorferi sensu lato

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Chronic Lyme arthritis. Clinical and immunogenetic differentiation from rheumatoid arthritis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

The clinical spectrum and treatment of Lyme disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Outer surface protein A (OspA) from the Lyme disease spirochete, Borrelia burgdorferi: high level expression and purification of a soluble recombinant form of OspA.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

Experimental Borrelia burgdorferi infection in inbred mouse strains: antibody response and association of H-2 genes with resistance and susceptibility to development of arthritis.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=337048

A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease. Recombinant Outer-Surface Protein A Lyme Disease Vaccine Study Consortium

11 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0305680101

Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0305680101

Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1 alpha L is a partial agonist for outer surface protein A-reactive T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0305680101

Biophysical and molecular mechanisms of Shaker potassium channel inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0305680101

Protection against tick-transmitted Lyme disease in dogs vaccinated with a multiantigenic vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0305680101

21 January 2018

Chronic Lyme Arthritis

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0305680101

Binding of outer surface protein A and human lymphocyte function-associated antigen 1 peptides to HLA-DR molecules associated with antibiotic treatment-resistant Lyme arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0305680101

The Spirochetal Etiology of Lyme Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0305680101

Assessing the prevention effectiveness of local Lyme disease control

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0305680101

Occupational risk of Lyme disease in endemic areas of New York State

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0305680101

Recombinant Outer Surface Protein A from Borrelia burgdorferi Induces Antibodies Protective against Spirochetal Infection in Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0305680101

Immunogenicity of a recombinant Borrelia burgdorferi outer surface protein A vaccine against Lyme disease in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0305680101

The clinical evolution of Lyme arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0305680101

Association of chronic Lyme arthritis with HLA-DR4 and HLA-DR2 alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0305680101

Evaluation of the safety, reactogenicity and immunogenicity of three recombinant outer surface protein (OspA) lyme vaccines in healthy adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0305680101

Plasmid DNA and protein vaccination of mice to the outer surface protein A of Borrelia burgdorferi leads to induction of T helper cells with specificity for a major epitope and augmentation of protective IgG antibodies in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0305680101

Human T lymphocyte response to Borrelia burgdorferi infection: no correlation between human leukocyte function antigen type 1 peptide response and clinical status

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0305680101

Surveillance for Lyme disease--United States, 1992-1998

21 January 2018

1 reference

12 December 2020

Arthritis following recombinant outer surface protein A vaccination for Lyme disease

1 reference

12 December 2020

Adverse event reports following vaccination for Lyme disease: December 1998-July 2000

1 reference

12 December 2020

CNS manifestations of third stage Lyme disease

1 reference

12 December 2020

Inability of truncated recombinant Osp A proteins to elicit protective immunity to Borrelia burgdorferi in mice

1 reference

12 December 2020

Identification of a Borrelia burgdorferi OspA T cell epitope that promotes anti-OspA IgG in mice

1 reference

12 December 2020

T helper 1 response is dominant and localized to the synovial fluid in patients with Lyme arthritis

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0305680101

1 reference

11 August 2017

0 references

1 reference

11 August 2017

PubMed publication ID

14742868

1 reference