A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcγRIIIa-mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques (Q36023146)

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English	A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcγRIIIa-mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

11 August 2017

A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcγRIIIa-mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques (English)

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Europe PubMed Central

PMC publication ID

11 August 2017

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based on heuristic

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monoclonal antibody

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based on heuristic

inferred from title

Samantha L Finstad

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Samantha L Finstad

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Falk Nimmerjahn

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Falk Nimmerjahn

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David I Watkins

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David I Watkins

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11 August 2017

Pascal Poignard

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Pascal Poignard

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Dennis R. Burton

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Dennis R Burton

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Galit Alter

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Donald N Forthal

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Donald N Forthal

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11 August 2017

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Eva G Rakasz

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Ann J Hessell

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9

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Gary Landucci

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1

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Brian Moldt

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11 August 2017

Niccole Schultz

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Niccole Schultz

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11 August 2017

author name string

Mami Shibata-Koyama

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11 August 2017

Yutaka Kanda

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11 August 2017

D Cameron Dunlop

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11 August 2017

Chenggang Jin

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11 August 2017

Michael D Alpert

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Anne-Sophie Dugast

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11 August 2017

Paul W H I Parren

12

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11 August 2017

David T Evans

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Jörn E Schmitz

17

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Shigeru Iida

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11 August 2017

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publication date

28 March 2012

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11 August 2017

Journal of Virology

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11 August 2017

86

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11 August 2017

11

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11 August 2017

6189-6196

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11 August 2017

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372207

2 October 2017

High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses

1 reference

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Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody

1 reference

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2 October 2017

Antibody-dependent cell-mediated cytotoxicity in simian immunodeficiency virus-infected rhesus monkeys

1 reference

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2 October 2017

Natural killer cells in spontaneous control of HIV infection.

1 reference

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The broadly neutralizing HIV-1 IgG 2F5 elicits gp41-specific antibody-dependent cell cytotoxicity in a FcγRI-dependent manner.

1 reference

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Fc-glycosylation influences Fcγ receptor binding and cell-mediated anti-HIV activity of monoclonal antibody 2G12.

1 reference

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2 October 2017

A dimeric form of the HIV-1 antibody 2G12 elicits potent antibody-dependent cellular cytotoxicity

1 reference

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2 October 2017

Fc receptor-mediated antiviral antibodies

1 reference

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Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand

1 reference

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Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target

1 reference

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Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques

1 reference

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Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers

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Contribution of nonneutralizing vaccine-elicited antibody activities to improved protective efficacy in rhesus macaques immunized with Tat/Env compared with multigenic vaccines.

1 reference

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Rapid degranulation of NK cells following activation by HIV-specific antibodies.

1 reference

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The utility of ADCC responses in HIV infection

1 reference

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Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells

1 reference

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Robust NK cell-mediated human immunodeficiency virus (HIV)-specific antibody-dependent responses in HIV-infected subjects

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Mamu-B*08-positive macaques control simian immunodeficiency virus replication

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A nonfucosylated anti-HER2 antibody augments antibody-dependent cellular cytotoxicity in breast cancer patients

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The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication

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Establishment of FUT8 knockout Chinese hamster ovary cells: an ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity

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Antibody-dependent cell-mediated cytotoxic responses in participants enrolled in a phase I/II ALVAC-HIV/AIDSVAX B/E prime-boost HIV-1 vaccine trial in Thailand

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10.1128/JVI.00491-12

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

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