A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge (Q36024470)

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English	A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge	scientific article

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Europe PubMed Central

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11 August 2017

A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge (English)

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Europe PubMed Central

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11 August 2017

David B. Allison

6

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11 August 2017

Andrea M Weiler

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Andrea M Weiler

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11 August 2017

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David I Watkins

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David I Watkins

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11 August 2017

Shari M Piaskowski

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Shari M Piaskowski

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11 August 2017

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4

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Michael Piatak

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11 August 2017

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12

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Wayne C Koff

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11 August 2017

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author name string

Matthew R Reynolds

1

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11 August 2017

Henry T Robertson

5

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11 August 2017

Andrew J Bett

7

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11 August 2017

Danilo R Casimiro

8

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11 August 2017

John W Shiver

9

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11 August 2017

Nancy A Wilson

10

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11 August 2017

Jeffrey D Lifson

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11 August 2017

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publication date

6 May 2012

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11 August 2017

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11 August 2017

30

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11 August 2017

30

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Europe PubMed Central

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11 August 2017

4465-4475

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Europe PubMed Central

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11 August 2017

Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372643

2 October 2017

Low-dose penile SIVmac251 exposure of rhesus macaques infected with adenovirus type 5 (Ad5) and then immunized with a replication-defective Ad5-based SIV gag/pol/nef vaccine recapitulates the results of the phase IIb step trial of a similar HIV-1 va

1 reference

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2 October 2017

The TRIM5 gene modulates penile mucosal acquisition of simian immunodeficiency virus in rhesus monkeys

1 reference

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2 October 2017

The TRIM5{alpha} genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge

1 reference

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2 October 2017

Mapping HIV-1 vaccine induced T-cell responses: bias towards less-conserved regions and potential impact on vaccine efficacy in the Step study

1 reference

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Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study

1 reference

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Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys

1 reference

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Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial

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An Ad5-vectored HIV-1 vaccine elicits cell-mediated immunity but does not affect disease progression in HIV-1-infected male subjects: results from a randomized placebo-controlled trial (the Step study)

1 reference

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2 October 2017

Host genetic determinants of T cell responses to the MRKAd5 HIV-1 gag/pol/nef vaccine in the step trial

1 reference

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Novel adenovirus vector-based vaccines for HIV-1.

1 reference

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Comparison of T cell immune responses induced by vectored HIV vaccines in non-human primates and humans

1 reference

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TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species

1 reference

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2 October 2017

Macaques vaccinated with simian immunodeficiency virus SIVmac239Delta nef delay acquisition and control replication after repeated low-dose heterologous SIV challenge

1 reference

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2 October 2017

Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys

1 reference

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2 October 2017

TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus Monkeys

1 reference

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2 October 2017

Efficacy of multivalent adenovirus-based vaccine against simian immunodeficiency virus challenge

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Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand

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Power to detect the effects of HIV vaccination in repeated low-dose challenge experiments

1 reference

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2 October 2017

Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1.

1 reference

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2 October 2017

Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challenge

1 reference

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2 October 2017

Assessing vaccine effects in repeated low-dose challenge experiments.

1 reference

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2 October 2017

Post-step modifications for research on HIV vaccines

1 reference

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2 October 2017

HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis

1 reference

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2 October 2017

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

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Macaques vaccinated with live-attenuated SIV control replication of heterologous virus

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2 October 2017

Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans

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2 October 2017

The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development?

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Loss of T cell responses following long-term cryopreservation

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Mamu-B*08-positive macaques control simian immunodeficiency virus replication

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Predictors of disease progression in HIV infection: a review

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Coping with viral diversity in HIV vaccine design

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Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and D

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Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys

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Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239

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1 reference

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Identifiers

10.1016/J.VACCINE.2012.04.082

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

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