Cyclosporin A and cardioprotection: from investigative tool to therapeutic agent. (Q36024824)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21955136%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

review article

1 reference

title

Cyclosporin A and cardioprotection: from investigative tool to therapeutic agent (English)

1 reference

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13 February 2020

1 reference

1

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13 February 2020

author name string

E A Boston-Griffiths

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21955136%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

D M Yellon

series ordinal

3

1 reference

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13 February 2020

language of work or name

English

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publication date

1 March 2012

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21955136%20AND%20SRC:MED&resulttype=core&format=json

British Journal of Pharmacology

13 February 2020

published in

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13 February 2020

volume

165

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13 February 2020

issue

5

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13 February 2020

page(s)

1235-1245

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21955136%20AND%20SRC:MED&resulttype=core&format=json

The mitochondrial permeability transition pore and cyclophilin D in cardioprotection

13 February 2020

cites work

1 reference

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Mitochondrial cyclophilin-D as a potential therapeutic target for post-myocardial infarction heart failure

2 October 2017

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Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice

2 October 2017

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Cyclosporine A at reperfusion reduces infarct size in pigs

2 October 2017

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Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation

2 October 2017

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Mitochondria and reperfusion injury of the heart--a holey death but not beyond salvation

2 October 2017

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Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning.

2 October 2017

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Myocardial reperfusion injury.

2 October 2017

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Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure

2 October 2017

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Cardioprotective effects of cyclosporine A in an in vivo model of myocardial ischemia and reperfusion

2 October 2017

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Preconditioning and postconditioning: the essential role of the mitochondrial permeability transition pore

2 October 2017

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Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

2 October 2017

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Real-time 2-photon imaging of mitochondrial function in perfused rat hearts subjected to ischemia/reperfusion

2 October 2017

1 reference

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Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

2 October 2017

1 reference

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

2 October 2017

1 reference

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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

2 October 2017

1 reference

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Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.

2 October 2017

1 reference

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Preconditioning protects by inhibiting the mitochondrial permeability transition

2 October 2017

1 reference

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The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

2 October 2017

1 reference

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Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury

2 October 2017

1 reference

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Pharmacological preconditioning with low-dose cyclosporine or FK506 reduces subsequent ischemia/reperfusion injury in rat kidney

2 October 2017

1 reference

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Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart.

2 October 2017

1 reference

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The mitochondrial permeability transition pore and its role in cell death

2 October 2017

1 reference

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Cyclophilin: a specific cytosolic binding protein for cyclosporin A

2 October 2017

1 reference

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Myocardial reperfusion: a double-edged sword?

2 October 2017

1 reference

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The entrapment of the Ca2+ indicator arsenazo III in the matrix space of rat liver mitochondria by permeabilization and resealing. Na+-dependent and -independent effluxes of Ca2+ in arsenazo III-loaded mitochondria

2 October 2017

1 reference

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Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

2 October 2017

1 reference

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Mechanisms by which mitochondria transport calcium

2 October 2017

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Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adeni

2 October 2017

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The discovery and development of cyclosporine (Sandimmune).

2 October 2017

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

2 October 2017

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Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin

2 October 2017

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Cyclosporin inhibits mitochondrial calcium efflux in isolated adult rat ventricular cardiomyocytes

2 October 2017

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The mechanism of action of cyclosporin A and FK506

2 October 2017

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Mitochondrial Ca2+ influx and efflux rates in guinea pig cardiac mitochondria: low and high affinity effects of cyclosporine A

2 October 2017

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Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury

11 July 2018

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Cyclosporine A limits myocardial infarct size even when administered after onset of ischemia

11 July 2018

1 reference

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Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion

11 July 2018

1 reference

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Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress

11 July 2018

1 reference

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Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria

11 July 2018

1 reference

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The reversible Ca2+-induced permeabilization of rat liver mitochondria

11 July 2018

1 reference

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Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa. One gene codes for both the cytosolic and mitochondrial forms.

11 July 2018

1 reference

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Impairment by cyclosporin A of reperfusion-induced arrhythmias

11 July 2018

1 reference

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Cyclosporin A protects against ischemia-reperfusion injury in the brain

11 July 2018

1 reference

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Cyclosporine does not reduce myocardial infarct size in a porcine ischemia-reperfusion model

11 July 2018

1 reference

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Effect of cyclosporine on left ventricular remodeling after reperfused myocardial infarction

23 September 2018

1 reference

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TRO40303, a new cardioprotective compound, inhibits mitochondrial permeability transition.

23 September 2018

1 reference

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Cyclosporine A administered during reperfusion fails to restore cardioprotection in prediabetic Zucker obese rats in vivo

23 September 2018

1 reference

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Time to take myocardial reperfusion injury seriously

23 September 2018

1 reference

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Effect of cyclosporine on reperfusion injury in acute myocardial infarction

23 September 2018

1 reference

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Inhibition of mitochondrial remodeling by cyclosporine A preserves myocardial performance in a neonatal rabbit model of cardioplegic arrest.

23 September 2018

1 reference

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Preconditioning the diabetic heart: the importance of Akt phosphorylation

23 September 2018

1 reference

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Mitochondrial permeability transition pore as a target for cardioprotection in the human heart

23 September 2018

1 reference

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Preconditioning delays Ca2+-induced mitochondrial permeability transition

23 September 2018

1 reference

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Protection of myocardium by cyclosporin a and insulin: in vitro simulated ischemia study in human myocardium

23 September 2018

1 reference

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Ischaemic preconditioning inhibits opening of mitochondrial permeability transition pores in the reperfused rat heart

23 September 2018

1 reference

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Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine.

23 September 2018

1 reference

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Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?

23 September 2018

1 reference

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Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A.

23 September 2018

1 reference

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Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca(2+) overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection

23 September 2018

1 reference

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Failure to precondition pathological human myocardium

23 September 2018

1 reference

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Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion

23 September 2018

1 reference

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Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372712

Involvement of Cyclophilin D in the Activation of A mitochondrial Pore by Ca2+ and Oxidant Stress

23 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01700.X

Giant mitochondria in renal tubular cells and cyclosporin A

21 January 2018

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12 December 2020

Giant mitochondria in renal tubular cells and cyclosporin

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12 December 2020

Cyclosporine improves outcome in high-risk cadaveric renal allograft recipients

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12 December 2020

Influence of cyclosporin A on the respiration of isolated rat kidney mitochondria

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12 December 2020

Action of cyclosporine on mitochondrial calcium fluxes

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12 December 2020

Alleviation of cyclosporine nephrotoxicity with verapamil and ATP-MgCl2. Mitochondrial respiratory and calcium studies

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12 December 2020

Beneficial effect of cyclosporine pretreatment in preventing ischemic damage to the liver in dogs

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12 December 2020

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

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12 December 2020

The beneficial effect of cyclosporine on liver ischemia in rats

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12 December 2020

Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A

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12 December 2020

A fresh look at reperfusion injury

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12 December 2020

Cyclosporin-A reduces leukocyte accumulation and protects against myocardial ischaemia reperfusion injury in rats

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12 December 2020

Postconditioning inhibits mitochondrial permeability transition

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12 December 2020

Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice

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12 December 2020

Inhibition of mitochondrial permeability transition to prevent the post-cardiac arrest syndrome: a pre-clinical study

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12 December 2020

Transient mitochondrial permeability transition pore opening after neonatal cardioplegic arrest

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12 December 2020

Cyclosporin A inhibits cardiac hypertrophy and enhances cardiac dysfunction during postinfarction failure in rats

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12 December 2020

The mitochondrial permeability transition pore: its fundamental role in mediating cell death during ischaemia and reperfusion

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12 December 2020

10.1111/J.1476-5381.2011.01700.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21955136%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21955136%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference