Unraveling the pathogenesis of type 1 diabetes with proteomics: present and future directions (Q36033860)

11 August 2017

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title

Unraveling the pathogenesis of type 1 diabetes with proteomics: present and future directions (English)

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11 August 2017

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Martin R Larsen

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Flemming Pociot

object named as

Flemming Pociot

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author name string

Thomas Sparre

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11 August 2017

Peter E Heding

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11 August 2017

Allan E Karlsen

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11 August 2017

Ole N Jensen

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11 August 2017

language of work or name

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7 February 2005

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Molecular & Cellular Proteomics

11 August 2017

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11 August 2017

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11 August 2017

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11 August 2017

441-457

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11 August 2017

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Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention

21 January 2018

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Globalization, coca-colonization and the chronic disease epidemic: can the Doomsday scenario be averted?

21 January 2018

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Global and societal implications of the diabetes epidemic

21 January 2018

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Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group

21 January 2018

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Diabetes trends in Europe

21 January 2018

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Increasing prevalence of diabetes mellitus and impaired glucose tolerance among 60-year-old Danes

21 January 2018

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A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

21 January 2018

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EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

21 January 2018

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A review of the recent epidemiological data on the worldwide incidence of type 1 (insulin-dependent) diabetes mellitus. World Health Organization DIAMOND Project Group

21 January 2018

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Genetics of type 1 diabetes mellitus

21 January 2018

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Environmental factors in the etiology of type 1 diabetes

21 January 2018

1 reference

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A new look at viruses in type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis

21 January 2018

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Impaired fetal growth and atherosclerosis of carotid and peripheral arteries

21 January 2018

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Intrauterine growth retardation leads to the development of type 2 diabetes in the rat.

21 January 2018

1 reference

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Intrauterine low protein diet increases fetal beta-cell sensitivity to NO and IL-1 beta: the protective role of taurine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Effect of a diabetic environment in utero on predisposition to type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

On the pathogenesis of IDDM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Insulin-secreting beta-cells possess specific receptors for interleukin-1 beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Interleukin 1 inhibits insulin secretion from isolated rat pancreatic islets by a process that requires gene transcription and mRNA translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Tumour necrosis factor alpha production is upregulated in diabetes prone BB rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Islet expression of interferon-alpha precedes diabetes in both the BB rat and streptozotocin-treated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Comparison of cytokine effects on mouse pancreatic alpha-cell and beta-cell lines. Viability, secretory function, and MHC antigen expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Interleukin-1 beta induces the expression of an isoform of nitric oxide synthase in insulin-producing cells, which is similar to that observed in activated macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Endogenous nitric oxide induced by interleukin-1 beta in rat islets of Langerhans and HIT-T15 cells causes significant DNA damage as measured by the 'comet' assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

N omega-nitro-L-arginine methyl ester reduces the incidence of IDDM in BB/E rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Interferon- Induces Interleukin-1 Converting Enzyme Expression in Pancreatic Islets by an Interferon Regulatory Factor-1-Dependent Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Cell lines derived from pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Human autoimmune diabetes mellitus: lessons from BB rats and NOD mice--Caveat emptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Rat models of type 1 diabetes: genetics, environment, and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Epigenesis: the missing beat in biotechnology?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Heterozygosity: an expanding role in proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Application of genomics and proteomics in Type 1 diabetes pathogenesis research

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Autoimmune islet destruction in spontaneous type 1 diabetes is not beta-cell exclusive.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Two-dimensional protein database of human pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Tissue-specific expression of glucokinase: identification of the gene product in liver and pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Hexokinase isoenzymes of RIN-m5F insulinoma cells. Expression of glucokinase gene in insulin-producing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Origin of the beta cells of the islets of Langerhans is further questioned by the expression of neuronal intermediate filament proteins, peripherin and NF-L, in the rat insulinoma RIN5F cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Characterization of small-molecular-mass guanine-nucleotide-binding regulatory proteins in insulin-secreting cells and PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

High-resolution two-dimensional polyacrylamide gel electrophoresis reveals a glucose-response protein of 65 kDa in pancreatic islet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Proteomics as a Tool for Discovery: Proteins Implicated in Alzheimer's Disease are Highly Expressed in Normal Pancreatic Islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Gene regulatory factors in pancreatic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Beta-cell maturation leads to in vitro sensitivity to cytotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Tissue-specific expression of transfected human insulin genes in pluripotent clonal rat insulinoma lines induced during passage in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Protein expression changes in a cell system of beta-cell maturation reflect an acquired sensitivity to IL-1beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Proteome Analysis of Interleukin-1 -Induced Changes in Protein Expression in Rat Islets of Langerhans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Massive parallel gene expression profiling of RINm5F pancreatic islet beta-cells stimulated with interleukin-1beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

A comparison of selected mRNA and protein abundances in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Correlation between protein and mRNA abundance in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Two-dimensional electrophoresis of proteins: an updated protocol and implications for a functional analysis of the genome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Onset of type 1 diabetes: a dynamical instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Changes in expression of IL-1 beta influenced proteins in transplanted islets during development of diabetes in diabetes-prone BB rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

beta-Cell death during progression to diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Endocrine pancreas plasticity under physiological and pathological conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

beta-cell turnover: its assessment and implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Taurine supplementation to a low protein diet during foetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Islet function in offspring of mothers on low-protein diet during gestation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Taurine supplement in early life altered islet morphology, decreased insulitis and delayed the onset of diabetes in non-obese diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Intrauterine programming of fetal islet gene expression in rats--effects of maternal protein restriction during gestation revealed by proteome analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Nutritional influences on pancreatic development and potential links with non-insulin-dependent diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Programming of islet functions in the progeny of hyperinsulinemic/obese rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Lethality and centrality in protein networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Maneuvering in the complex path from genotype to phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Interleukin-1-induced expression of nitric oxide synthase in insulin-producing cells is preceded by c-fos induction and depends on gene transcription and protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

IL-1beta induces serine protease inhibitor 3 (SPI-3) gene expression in rat pancreatic beta-cells. Detection by differential display of messenger RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Expression profiling of pancreatic beta cells: glucose regulation of secretory and metabolic pathway genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Gene Microarray Study Corroborates Proteomic Findings in Rodent Islet Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Transcriptional program of the endocrine pancreas in mice and humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Gene expression profiles define a key checkpoint for type 1 diabetes in NOD mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Discordant protein and mRNA expression in lung adenocarcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

A genomic and proteomic analysis of activation of the human neutrophil by lipopolysaccharide and its mediation by p38 mitogen-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

A sampling of the yeast proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Complementary profiling of gene expression at the transcriptome and proteome levels in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Modulation of gene expression by extracellular pH variations in human fibroblasts: a transcriptomic and proteomic study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Proteomics meets cell biology: the establishment of subcellular proteomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Perspective: proteomics--see "spots" run.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Organelle proteomics: implications for subcellular fractionation in proteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

A comprehensive guide to antibody and T-cell responses in type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Low-molecular-weight human serum proteome using ultrafiltration, isoelectric focusing, and mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Current two-dimensional electrophoresis technology for proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Mass spectrometry-based proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Mass spectral analysis in proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

The application of mass spectrometry to membrane proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Advances in quantitative proteomics via stable isotope tagging and mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Accurate quantitation of protein expression and site-specific phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Metabolic labeling of mammalian organisms with stable isotopes for quantitative proteomic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Proteomic analysis of post-translational modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Modification-specific proteomics: characterization of post-translational modifications by mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

A new strategy for identification of N-glycosylated proteins and unambiguous assignment of their glycosylation sites using HILIC enrichment and partial deglycosylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Characterization of gel-separated glycoproteins using two-step proteolytic digestion combined with sequential microcolumns and mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Proteomic Analysis of Glycosylphosphatidylinositol-anchored Membrane Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Large-scale Analysis ofin VivoPhosphorylated Membrane Proteins by Immobilized Metal Ion Affinity Chromatography and Mass Spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

IL-1β induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

Increased Risk of Childhood Type 1 Diabetes in Children Born After 1985

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FMCP.R500002-MCP200

10.1074/MCP.R500002-MCP200

21 January 2018

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DOI

1 reference

11 August 2017

1 reference