α-Synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits (Q36034871)

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30 January 2020

title

α-Synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits (English)

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30 January 2020

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1 reference

1

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30 January 2020

Ole Isacson

5

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30 January 2020

author name string

Jesse R McLean

2

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30 January 2020

Andrew Kartunen

3

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30 January 2020

J William Langston

4

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30 January 2020

publication date

19 April 2012

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30 January 2020

published in

Neurobiology of Disease

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30 January 2020

volume

47

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30 January 2020

issue

2

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30 January 2020

page(s)

258-267

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Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression

30 January 2020

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Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

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Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes.

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Medical records documentation of constipation preceding Parkinson disease: A case-control study

2 October 2017

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Cardiovascular autonomic dysfunction in Parkinson's disease

2 October 2017

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The second brain and Parkinson's disease.

2 October 2017

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Alpha-synuclein immunopositive aggregates in the myenteric plexus of the aging Fischer 344 rat.

2 October 2017

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Nonmotor symptoms of Parkinson's disease revealed in an animal model with reduced monoamine storage capacity

2 October 2017

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Alterations in corticostriatal synaptic plasticity in mice overexpressing human alpha-synuclein

2 October 2017

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Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy.

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Olfactory deficits in mice overexpressing human wildtype alpha-synuclein

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Strengths and limitations of genetic mouse models of Parkinson's disease

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Abnormal colonic motility in mice overexpressing human wild-type alpha-synuclein

2 October 2017

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Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression

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2 October 2017

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Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease

11 July 2018

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Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

11 July 2018

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Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters

11 July 2018

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Loss of transmitter-associated enzyme staining following axotomy does not indicate death of brainstem cholinergic neurons.

11 July 2018

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11 July 2018

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What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them?

11 July 2018

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MPTP-induced parkinsonism extends to a subclass of TH-positive neurons in the gut.

23 September 2018

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Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: an anatomical study

23 September 2018

1 reference

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Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology.

23 September 2018

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Neurochemical plasticity in the enteric nervous system of a primate animal model of experimental Parkinsonism.

23 September 2018

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Cardiac sympathetic denervation in Parkinson's disease linked to SNCA duplication

23 September 2018

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Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease

23 September 2018

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Alteration of dopaminergic markers in gastrointestinal tract of different rodent models of Parkinson's disease

23 September 2018

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Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease

23 September 2018

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Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease

23 September 2018

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Pathology of the sympathetic nervous system corresponding to the decreased cardiac uptake in 123I-metaiodobenzylguanidine (MIBG) scintigraphy in a patient with Parkinson disease

23 September 2018

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Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein.

23 September 2018

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Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

23 September 2018

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alpha-synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain stem nuclei

23 September 2018

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Alpha-synuclein accumulation in a case of neurodegeneration with brain iron accumulation type 1 (NBIA-1, formerly Hallervorden-Spatz syndrome) with widespread cortical and brainstem-type Lewy bodies

23 September 2018

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Impaired cardiac uptake of meta-[123I]iodobenzylguanidine in Parkinson's disease with autonomic failure

21 October 2018

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12 December 2020

Cardiac sympathetic denervation in Parkinson disease

1 reference

12 December 2020

Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses

1 reference

12 December 2020

Cardiac sympathetic denervation preceding motor signs in Parkinson disease*

1 reference

12 December 2020

Gastrointestinal, urological, and sexual dysfunction in Parkinson's disease

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12 December 2020

Skin biopsy for assessment of autonomic denervation in Parkinson's disease

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12 December 2020

Gastrointestinal dysfunction in Parkinson’s disease

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12 December 2020

10.1016/J.NBD.2012.04.009

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22549133%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22549133%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PubMed publication ID

22549133

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22549133%20AND%20SRC:MED&resulttype=core&format=json