The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the rat (Q36036237)

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English	The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the rat	scientific article

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18 February 2020

The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the rat (English)

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18 February 2020

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18 February 2020

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L Nagy

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18 February 2020

Á Kovács

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18 February 2020

B Bódi

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18 February 2020

E T Pásztor

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18 February 2020

G Á Fülöp

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18 February 2020

I Édes

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18 February 2020

Z Papp

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18 February 2020

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4 August 2015

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18 February 2020

British Journal of Pharmacology

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18 February 2020

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18 February 2020

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18 February 2020

4506-4518

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18 February 2020

Effects of a myofilament calcium sensitizer on left ventricular systolic and diastolic function in rats with volume overload heart failure

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2 October 2017

Analytical comparison of natural and pharmaceutical ventricular myosin activators

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2 October 2017

Inotropes and inodilators for acute heart failure: sarcomere active drugs in focus

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2 October 2017

Sarcomere length nanometry in rat neonatal cardiomyocytes expressed with α-actinin-AcGFP in Z discs.

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2 October 2017

Diaphragm dysfunction in heart failure is accompanied by increases in neutral sphingomyelinase activity and ceramide content

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2 October 2017

An overview of recent developments in the treatment of heart failure: update from the ESC Congress 2013.

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2 October 2017

ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the

1 reference

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2 October 2017

Fiber types in mammalian skeletal muscles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562511

2 October 2017

The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial.

1 reference

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2 October 2017

Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study

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2 October 2017

Cardiac myosin activation: a potential therapeutic approach for systolic heart failure

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2 October 2017

Animal research: reporting in vivo experiments: the ARRIVE guidelines

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2 October 2017

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

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2 October 2017

Improvement of cardiac function by a cardiac Myosin activator in conscious dogs with systolic heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562511

2 October 2017

Calcium sensitisation impairs diastolic relaxation in post-ischaemic myocardium: implications for the use of Ca(2+) sensitising inotropes after cardiac surgery

1 reference

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2 October 2017

A novel approach to improve cardiac performance: cardiac myosin activators

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562511

2 October 2017

Cardiac Ca2+ signaling and Ca2+ sensitizers

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562511

2 October 2017

Mechanisms and use of calcium-sensitizing agents in the failing heart

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562511

2 October 2017

Sarcomeric determinants of striated muscle relaxation kinetics

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562511

2 October 2017

Myosin crossbridge activation of cardiac thin filaments: implications for myocardial function in health and disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562511

2 October 2017

The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phosphodiesterase enzymes of the guinea pig

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2 October 2017

Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562511

2 October 2017

Mechanism of action of Ca2+ sensitizers--update 2001.

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2 October 2017

Strong binding of myosin increases shortening velocity of rabbit skinned skeletal muscle fibres at low levels of Ca(2+)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562511

2 October 2017

Regulation of contraction in striated muscle

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2 October 2017

Small molecule-mediated refolding and activation of myosin motor function

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11 July 2018

Electrophoretic separation of rat skeletal muscle myosin heavy-chain isoforms.

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11 July 2018

The 'calcium sensitising' effects of ORG30029 in saponin- or Triton-skinned rat cardiac muscle

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11 July 2018

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11 July 2018

Omecamtiv Mecarbil modulates the kinetic and motile properties of porcine β-cardiac myosin

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23 September 2018

Mechanical and kinetic properties of β-cardiac/slow skeletal muscle myosin

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23 September 2018

Translational medicine: to the rescue of the failing heart

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562511

23 September 2018

Effects of Ca2+ -sensitizers in permeabilized cardiac myocytes from donor and end-stage failing human hearts

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23 September 2018

Omecamtiv mecarbil: a promising new drug in systolic heart failure

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21 January 2018

Isometric tension development and its calcium sensitivity in skinned myocyte-sized preparations from different regions of the human heart

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21 January 2018

The effects of EMD 57033 on rigor tension in porcine skinned cardiac trabecula

1 reference

https://pubmed.ncbi.nlm.nih.gov/26140433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypermuscular mice with mutation in the myostatin gene display altered calcium signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/26140433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tension response of the cardiotonic agent (+)-EMD-57033 at the single cell level

1 reference

https://pubmed.ncbi.nlm.nih.gov/26140433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different effect of the Ca(2+) sensitizers EMD 57033 and CGP 48506 on cross-bridge cycling in human myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/26140433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/26140433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-bridge interaction kinetics in rat myocardium are accelerated by strong binding of myosin to the thin filament

1 reference

https://pubmed.ncbi.nlm.nih.gov/26140433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Negative lusitropy and abnormal calcium handling in hypoxic cardiac myocytes exposed to the calcium-sensitizer EMD 53998

1 reference

https://pubmed.ncbi.nlm.nih.gov/26140433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EMD 57033 partially reverses ventilator-induced diaphragm muscle fibre calcium desensitisation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26140433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereoselective actions of thiadiazinones on canine cardiac myocytes and myofilaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/26140433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The calcium sensitizer levosimendan improves human diaphragm function

1 reference

https://pubmed.ncbi.nlm.nih.gov/26140433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/BPH.13235

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18 February 2020

PMC publication ID

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18 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

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18 February 2020

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