Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans (Q36053421)

11 August 2017

Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans (English)

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11 August 2017

D J Carlile

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11 August 2017

N Hakooz

series ordinal

2

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11 August 2017

M K Bayliss

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3

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11 August 2017

J B Houston

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4

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11 August 2017

language of work or name

English

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publication date

1 June 1999

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British Journal of Clinical Pharmacology

11 August 2017

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11 August 2017

47

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11 August 2017

6

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11 August 2017

625-635

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Protein measurement with the Folin phenol reagent

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Prediction of in vivo disposition from in vitro systems: clearance of phenytoin and tolbutamide using rat hepatic microsomal and hepatocyte data.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Steady-state pharmacokinetics of phenytoin from routinely collected patient data

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Stereoselective disposition of ibuprofen enantiomers in man

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Cotrimoxazole as an inhibitor of oxidative drug metabolism: effects of trimethoprim and sulphamethoxazole separately and combined on tolbutamide disposition

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Comparative effects of two antimycotic agents, ketoconazole and terbinafine on the metabolism of tolbutamide, ethinyloestradiol, cyclosporin and ethoxycoumarin by human liver microsomes in vitro

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

A screening test for slow metabolisers of tolbutamide

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Co-regulation of phenytoin and tolbutamide metabolism in humans

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Alteration of drug metabolism in Gilbert's syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Biotransformation of diclofenac sodium (Voltaren) in animals and in man. I. Isolation and identification of principal metabolites

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

The pharmacokinetics and metabolism of diclofenac sodium (Voltarol) in animals and man

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Stereoselective plasma protein binding of ibuprofen enantiomers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Relationship between phenytoin and tolbutamide hydroxylations in human liver microsomes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Erythrocyte uptake and plasma binding of diphenylhydantoin.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Tolbutamide hydroxylation by human liver microsomes. Kinetic characterisation and relationship to other cytochrome P-450 dependent xenobiotic oxidations

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014252

Influence of acute viral hepatitis on disposition and plasma binding of tolbutamide

23 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1046%2FJ.1365-2125.1999.00935.X

Effects of age and gender on in vitro properties of human liver microsomal monooxygenases

21 January 2018

1 reference

12 December 2020

Stereoselective metabolism of ibuprofen in humans: administration of R-, S- and racemic ibuprofen

1 reference

12 December 2020

Cytochrome P450TB (CYP2C): a major monooxygenase catalyzing diclofenac 4'-hydroxylation in human liver

1 reference

12 December 2020

Tolbutamide hydroxylation in humans: lack of bimodality in 106 healthy subjects

1 reference

12 December 2020

In vivo inhibition profile of cytochrome P450TB (CYP2C9) by (±)-fluvastatin*

1 reference

12 December 2020

Effect of albumin on the estimation, in vitro, of phenytoin Vmax and Km values: implications for clinical correlation

1 reference

12 December 2020

High-performance liquid chromatographic determination of ibuprofen and its major metabolites in biological fluids

1 reference

12 December 2020

Extent of urinary excretion of p-hydroxyphenytoin in healthy subjects given phenytoin

1 reference

12 December 2020

The metabolic fate of tolbutamide in man and in the rat

1 reference

12 December 2020

Phenytoin: Pharmacokinetics and bioavailability

1 reference

12 December 2020

The influence of disulfiram on the half life and metabolic clearance rate of diphenylhydantoin and tolbtamide in man

1 reference

12 December 2020

The elimination of phenytoin in man

1 reference

12 December 2020

Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance

1 reference

12 December 2020

The pharmacokinetics of diclofenac sodium following intravenous and oral administration

1 reference

12 December 2020

In vivo pharmacokinetics of felodipine predicted from in vitro studies in rat, dog and man

1 reference

12 December 2020

In vitro protein binding of diclofenac sodium in plasma and synovial fluid

1 reference

12 December 2020

Selective inhibition of drug oxidation after simultaneous administration of two probe drugs, antipyrine and tolbutamide

1 reference

12 December 2020

Pharmacokinetics of diclofenac and five metabolites after single doses in healthy volunteers and after repeated doses in patients

1 reference

12 December 2020

10.1046/J.1365-2125.1999.00935.X

Identifiers

DOI

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11 August 2017

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11 August 2017

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