Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on the brain distribution of a novel BRAF inhibitor: vemurafenib (PLX4032) (Q36057973)

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English	Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on the brain distribution of a novel BRAF inhibitor: vemurafenib (PLX4032)	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

11 August 2017

Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on the brain distribution of a novel BRAF inhibitor: vemurafenib (PLX4032) (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

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author name string

Rajendar K Mittapalli

1

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Europe PubMed Central

PMC publication ID

11 August 2017

Shruthi Vaidhyanathan

2

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Europe PubMed Central

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11 August 2017

Ramola Sane

3

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Europe PubMed Central

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11 August 2017

William F Elmquist

4

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11 August 2017

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publication date

27 March 2012

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11 August 2017

Journal of Pharmacology and Experimental Therapeutics

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Europe PubMed Central

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11 August 2017

342

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Europe PubMed Central

PMC publication ID

11 August 2017

1

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Europe PubMed Central

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11 August 2017

33-40

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Europe PubMed Central

PMC publication ID

11 August 2017

Quantitative proteomics of transporter expression in brain capillary endothelial cells isolated from P-glycoprotein (P-gp), breast cancer resistance protein (Bcrp), and P-gp/Bcrp knockout mice

1 reference

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Immunohistochemical testing of BRAF V600E status in 1,120 tumor tissue samples of patients with brain metastases

1 reference

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Targeting the RAS pathway in melanoma

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Improved survival with vemurafenib in melanoma with BRAF V600E mutation

1 reference

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Targeting BRAF in advanced melanoma: a first step toward manageable disease

1 reference

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Systematic review of medical treatment in melanoma: current status and future prospects.

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Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K

1 reference

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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

1 reference

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

1 reference

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2 October 2017

The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain

1 reference

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Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux

1 reference

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2 October 2017

P-glycoprotein and breast cancer resistance protein influence brain distribution of dasatinib

1 reference

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2 October 2017

Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors.

1 reference

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Brain and leptomeningeal metastases from cutaneous melanoma: survival outcomes based on clinical features

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2 October 2017

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

1 reference

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Blood-brain barrier active efflux transporters: ATP-binding cassette gene family

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Determinants of outcome in melanoma patients with cerebral metastases

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

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Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

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Mutations of the BRAF gene in human cancer

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Demographics of brain metastasis.

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1 reference

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Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma.

1 reference

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An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amin

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P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan

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Identifiers

10.1124/JPET.112.192195

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

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