The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes (Q36061917)

11 August 2017

The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes (English)

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11 August 2017

Caenorhabditis elegans

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author

Elisa Izaurralde

series ordinal

4

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11 August 2017

2

Eric Huntzinger

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11 August 2017

Duygu Kuzuoglu-Öztürk

series ordinal

1

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11 August 2017

Steffen Schmidt

series ordinal

3

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11 August 2017

language of work or name

English

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publication date

7 March 2012

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11 August 2017

Nucleic Acids Research

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11 August 2017

40

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11 August 2017

12

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11 August 2017

5651-5665

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Creative Commons Attribution-NonCommercial 3.0 Unported

11 August 2017

start time

7 November 2016

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro

1 reference

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miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT

2 October 2017

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miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs

2 October 2017

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GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets

2 October 2017

1 reference

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Attributes of short linear motifs.

2 October 2017

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Gene silencing by microRNAs: contributions of translational repression and mRNA decay

2 October 2017

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Pervasive and cooperative deadenylation of 3'UTRs by embryonic microRNA families.

2 October 2017

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Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing

2 October 2017

1 reference

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Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein

2 October 2017

1 reference

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Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

2 October 2017

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The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation

2 October 2017

1 reference

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The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing

2 October 2017

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The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins

2 October 2017

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The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing

2 October 2017

1 reference

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Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression.

2 October 2017

1 reference

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Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila

2 October 2017

1 reference

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The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

Reiterated WG/GW motifs form functionally and evolutionarily conserved ARGONAUTE-binding platforms in RNAi-related components.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

GW182 family proteins are crucial for microRNA-mediated gene silencing

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

The HHpred interactive server for protein homology detection and structure prediction

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

Positive and negative regulation of poly(A) nuclease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

A C-terminal silencing domain in GW182 is essential for miRNA function

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384334

23 September 2018

Identifiers

DOI

10.1093/NAR/GKS218

1 reference

11 August 2017

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11 August 2017

PubMed publication ID

22402495

1 reference