Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A-induced cytotoxicity (Q36072775)

12 August 2017

Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A-induced cytotoxicity (English)

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12 August 2017

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Vojo Deretic

5

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Wojciech Ornatowski

series ordinal

1

object named as

Wojciech Ornatowski

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12 August 2017

3

Elizabeth Perkett

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12 August 2017

2

Jens F Poschet

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12 August 2017

Jennifer L Taylor-Cousar

series ordinal

4

1 reference

12 August 2017

language of work or name

English

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publication date

1 November 2007

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Journal of Clinical Investigation

12 August 2017

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12 August 2017

117

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12 August 2017

11

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12 August 2017

3489-3497

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describes a project that uses

12 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2030457/fullTextXML

inferred from PubMed Central ID database lookup

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The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo

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2 October 2017

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Furin at the cutting edge: from protein traffic to embryogenesis and disease

2 October 2017

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Processing of immunosuppressive pro-TGF-beta 1,2 by human glioblastoma cells involves cytoplasmic and secreted furin-like proteases

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2 October 2017

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Pseudomonas aeruginosa induction of apoptosis in respiratory epithelial cells: analysis of the effects of cystic fibrosis transmembrane conductance regulator dysfunction and bacterial virulence factors

2 October 2017

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Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec61p channel

2 October 2017

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TGF-beta(1) genotype and accelerated decline in lung function of patients with cystic fibrosis

2 October 2017

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Enhanced macrophage resistance to Pseudomonas exotoxin A is correlated with decreased expression of the low-density lipoprotein receptor-related protein.

2 October 2017

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Inducible nitric oxide synthase expression is reduced in cystic fibrosis murine and human airway epithelial cells

2 October 2017

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Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects

2 October 2017

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Elevation of vacuolar pH inhibits the cytotoxic activity of furin-cleaved exotoxin A.

2 October 2017

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TGFbeta1 regulates gene expression of its own converting enzyme furin

2 October 2017

1 reference

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Transforming growth factors-beta 1, -beta 2, and -beta 3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis

2 October 2017

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Overexpression of R domain eliminates cAMP-stimulated Cl- secretion in 9/HTEo- cells in culture.

2 October 2017

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Role of CAS, a human homologue to the yeast chromosome segregation gene CSE1, in toxin and tumor necrosis factor mediated apoptosis

2 October 2017

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Furin regulates both the activation of Pseudomonas exotoxin A and the Quantity of the toxin receptor expressed on target cells

2 October 2017

1 reference

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Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections.

2 October 2017

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In vivo production of exotoxin A and its role in endogenous Pseudomonas aeruginosa septicemia in mice.

2 October 2017

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Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases

2 October 2017

1 reference

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Production of elastase, exotoxin A, and alkaline protease in sputa during pulmonary exacerbation of cystic fibrosis in patients chronically infected by Pseudomonas aeruginosa

2 October 2017

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Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface

2 October 2017

1 reference

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Transforming growth factor beta as a virulence mechanism for Leishmania braziliensis

2 October 2017

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CFTR as a cAMP-dependent regulator of sodium channels

2 October 2017

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Cellular ADP-ribosyltransferase with the same mechanism of action as diphtheria toxin and Pseudomonas toxin A

2 October 2017

1 reference

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Pseudomonas exotoxin: chimeric toxins

2 October 2017

1 reference

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Characterization of human tracheal epithelial cells transformed by an origin-defective simian virus 40.

2 October 2017

1 reference

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Transforming growth factor-beta activity in sheep lung lymph during the development of pulmonary hypertension

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2030457

Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta).

2 October 2017

1 reference

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Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2030457

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2030457

Comparative Toxicities of Diphtherial Toxin and Pseudomonas aeruginosa Exotoxin A: Evidence for Different Cell Receptors

2 October 2017

1 reference

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Nonclassical pathway of Pseudomonas aeruginosa DNA-induced interleukin-8 secretion in cystic fibrosis airway epithelial cells

2 October 2017

1 reference

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Reduced Smad3 protein expression and altered transforming growth factor-beta1-mediated signaling in cystic fibrosis epithelial cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2030457

Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2030457

Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2030457

A Cystic Fibrosis Bronchial Epithelial Cell Line: Immortalization by Adeno-12-SV40 Infection

11 July 2018

1 reference

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Defective regulation of outwardly rectifying Cl- channels by protein kinase A corrected by insertion of CFTR

11 July 2018

1 reference

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End-organ dysfunction in cystic fibrosis: association with angiotensin I converting enzyme and cytokine gene polymorphisms.

11 July 2018

1 reference

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Control of nitric oxide production by transforming growth factor-beta1: mechanistic insights and potential relevance to human disease

23 September 2018

1 reference

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CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2030457

An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct

23 September 2018

1 reference

12 December 2020

Enhancement Of Intracellular Growth Of Mycobacterium Tuberculosis In Human Monocytes by Transforming Growth Factor- l

1 reference

12 December 2020

Furin activates Pseudomonas exotoxin A by specific cleavage in vivo and in vitro

1 reference

12 December 2020

Genetic modifiers of lung disease in cystic fibrosis

1 reference

12 December 2020

CFTR regulates phagosome acidification in macrophages and alters bactericidal activity

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12 December 2020

Diagnostic value of serum antibodies in early Pseudomonas aeruginosa infection in cystic fibrosis patients

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Cytokine expression in bronchial biopsies of cystic fibrosis patients with and without acute exacerbation

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12 December 2020

Identifiers

DOI

10.1172/JCI31499

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

17948127

1 reference