HFE gene mutations in susceptibility to childhood leukemia: HuGE review (Q36073704)

12 August 2017

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title

HFE gene mutations in susceptibility to childhood leukemia: HuGE review (English)

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12 August 2017

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M Tevfik Dorak

1

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12 August 2017

Alan K Burnett

series ordinal

2

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12 August 2017

Mark Worwood

series ordinal

3

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12 August 2017

language of work or name

English

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publication date

1 March 2005

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12 August 2017

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12 August 2017

7

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12 August 2017

159-168

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12 August 2017

3

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https://scigraph.springernature.com/pub.10.1097/01.gim.0000156532.04648.81

12 August 2017

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Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

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Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis

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Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation

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HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype

21 January 2018

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The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22.

21 January 2018

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A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis

21 January 2018

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Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3)

21 January 2018

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A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload

21 January 2018

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Polymorphisms in the transferrin 5' flanking region associated with differences in total iron binding capacity: possible implications in iron homeostasis

21 January 2018

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A study of genes that may modulate the expression of hereditary hemochromatosis: transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (IRP)-1 and -2, and hepcidin

21 January 2018

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Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease.

21 January 2018

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Interaction between haemochromatosis and transferrin receptor genes in hepatocellular carcinoma

21 January 2018

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Hematologically important mutations: iron storage diseases

21 January 2018

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Expression of HLA-linked hemochromatosis in subjects homozygous or heterozygous for the C282Y mutation.

21 January 2018

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A population-based study of the clinical expression of the hemochromatosis gene

21 January 2018

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Penetrance of 845G--> A (C282Y) HFE hereditary haemochromatosis mutation in the USA.

21 January 2018

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Hemochromatosis mutations in the general population: iron overload progression rate

21 January 2018

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The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression

21 January 2018

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Contribution of the H63D mutation in HFE to murine hereditary hemochromatosis

21 January 2018

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The significance of the 187G (H63D) mutation in hemochromatosis

21 January 2018

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Differential HFE allele expression in hemochromatosis heterozygotes

21 January 2018

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Contribution of different HFE genotypes to iron overload disease: a pooled analysis

21 January 2018

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Polymorphisms in the 5' flanking region of the HFE gene: linkage disequilibrium and relationship to iron homeostasis

21 January 2018

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A common intron 3 mutation (IVS3 -48c-->g) leads to misdiagnosis of the c.845G-->A (C282Y) HFE gene mutation

21 January 2018

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Global prevalence of putative haemochromatosis mutations

21 January 2018

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Molecular diagnosis of hereditary hemochromatosis: application of a newly-developed reverse-hybridization assay in the South African population.

21 January 2018

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Geography of HFE C282Y and H63D mutations

21 January 2018

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Aetiology of acute leukaemia

21 January 2018

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21 January 2018

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Genetic susceptibility to childhood acute lymphoblastic leukemia.

21 January 2018

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Childhood acute lymphoblastic leukemia: genetic determinants of susceptibility and disease outcome

21 January 2018

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The inheritance of pyloric stenosis explained by a multifactorial threshold model with sex dimorphism for liability.

21 January 2018

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Imprinting, the X-chromosome, and the male brain: explaining sex differences in the liability to autism

21 January 2018

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Mechanisms and regulation of intestinal iron absorption

21 January 2018

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The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

21 January 2018

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Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation.

21 January 2018

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The effects of wild-type and mutant HFE expression upon cellular iron uptake in transfected human embryonic kidney cells

21 January 2018

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Effects of HFE C282Y and H63D polymorphisms and polygenic background on iron stores in a large community sample of twins

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Clinical and biochemical abnormalities in people heterozygous for hemochromatosis

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

High prevalence of the hemochromatosis-associated Cys282Tyr HFE gene mutation in a healthy Norwegian population in the city of Oslo, and its phenotypic expression.

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

The effect of HFE genotypes on measurements of iron overload in patients attending a health appraisal clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Mixture distribution analysis of phenotypic markers reflecting HFE gene mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Mild iron overload in patients carrying the HFE S65C gene mutation: a retrospective study in patients with suspected iron overload and healthy controls.

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Body iron stores and the risk of cancer

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Epidemiologic evidence of an association between body iron stores and risk of cancer

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Heme iron, zinc, alcohol consumption, and colon cancer: Iowa Women's Health Study

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Serum iron, copper and zinc concentrations and risk of cancer mortality in US adults.

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Body iron stores and risk of colonic neoplasia

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Increased serum ferritin in chronic liver disease: a risk factor for primary hepatocellular carcinoma

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

HFE C282Y heterozygosity in hepatocellular carcinoma: evidence for an increased prevalence.

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Transferrin saturation and risk of cancer

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

The incidence of cancer among blood donors

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Iron-induced carcinogenesis: the role of redox regulation

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

The immunological system in hemochromatosis

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

The role of metals in site-specific DNA damage with reference to carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Molecular bases of cellular iron toxicity

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Iron status and cellular immune competence

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Iron withholding: a defense against viral infections

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Iron and susceptibility to infectious disease

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Iron enhances tumor growth. Observation on spontaneous mammary tumors in mice

21 January 2018

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Influence of dietary iron overload on cell proliferation and intestinal tumorigenesis in mice.

21 January 2018

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Sex hormone-dependent renal cell carcinogenesis induced by ferric nitrilotriacetate in Wistar rats.

21 January 2018

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Sex differences in oxidative damage in ddY mouse kidney treated with a renal carcinogen, iron nitrilotriacetate.

21 January 2018

1 reference

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Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis

21 January 2018

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Cancer risk following primary hemochromatosis: a population-based cohort study in Denmark.

21 January 2018

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Cancer risk in patients with hereditary hemochromatosis and in their first-degree relatives.

21 January 2018

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Dietary iron overload as a risk factor for hepatocellular carcinoma in Black Africans

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Most free-radical injury is iron-related: it is promoted by iron, hemin, holoferritin and vitamin C, and inhibited by desferoxamine and apoferritin

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Increased cancer risk in a cohort of 230 patients with hereditary hemochromatosis in comparison to matched control patients with non-iron-related chronic liver disease.

21 January 2018

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Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases

21 January 2018

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Association between hemochromatosis (HFE) gene mutation carrier status and the risk of colon cancer

21 January 2018

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Increased prevalence of the HFE C282Y hemochromatosis allele in women with breast cancer

21 January 2018

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High frequency of the H63D mutation of the hemochromatosis gene (HFE) in malignant gliomas.

21 January 2018

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HFE C282Y and H63D in adults with malignancies in a community medical oncology practice

21 January 2018

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Iron: a target for the management of Kaposi's sarcoma?

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Hemochromatosis gene in leukemia and lymphoma

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Iron transport in a lymphoid cell line with the hemochromatosis C282Y mutation

21 January 2018

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Iron, radiation, and cancer

21 January 2018

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Ferritin-iron increases killing of Chinese hamster ovary cells by X-irradiation

21 January 2018

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Prognostic factor in neuroblastoma.

21 January 2018

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Prognostic importance of serum transferrin and ferritin in childhood Hodgkin's disease

21 January 2018

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Epidemiological evidence for an infective basis in childhood leukaemia

21 January 2018

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Morbidity risk in HFE associated hereditary hemochromatosis C282Y heterozygotes

21 January 2018

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Longevity and carrying the C282Y mutation for haemochromatosis on the HFE gene: case control study of 492 French centenarians

21 January 2018

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Genes that modify the hemochromatosis phenotype in mice

21 January 2018

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The 16189 variant of mitochondrial DNA occurs more frequently in C282Y homozygotes with haemochromatosis than those without iron loading

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Mutations in the HFE gene and their interaction with exogenous risk factors in hepatocellular carcinoma

21 January 2018

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Hereditary hemochromatosis: effect of excessive alcohol consumption on disease expression in patients homozygous for the C282Y mutation

21 January 2018

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Oxidative stress, human genetic variation, and disease

21 January 2018

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Prooxidant states and tumor promotion

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

Iron and its sensitive balance in the cell

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

The role of genetic polymorphisms in environmental health

21 January 2018

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Critical windows of exposure for children's health: cancer in human epidemiological studies and neoplasms in experimental animal models

21 January 2018

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A population-based study of the effect of the HFE C282Y and H63D mutations on iron metabolism

21 January 2018

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https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

HFE genotype and transferrin saturation in the United States

21 January 2018

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Biochemical expression of heterozygous hereditary hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2F01.GIM.0000156532.04648.81

10.1097/01.GIM.0000156532.04648.81

21 January 2018

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DOI

1 reference

Dimensions Publication ID

12 August 2017

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1 reference