Extracellular proteases: biological and behavioral roles in the mammalian central nervous system (Q36096026)

12 August 2017

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title

Extracellular proteases: biological and behavioral roles in the mammalian central nervous system (English)

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12 August 2017

Yan Zhang

1

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PubMed ID

15825268

12 August 2017

Kostas Pothakos

series ordinal

2

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PubMed ID

15825268

12 August 2017

Styliana-Anna Stella Tsirka

series ordinal

3

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12 August 2017

1 January 2005

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Current Topics in Developmental Biology

12 August 2017

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12 August 2017

66

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12 August 2017

161-188

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The plasminogen activation system in tumor growth, invasion, and metastasis

12 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Neuronal Depolarization Enhances the Transcription of the Neuronal Serine Protease Inhibitor Neuroserpin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Structural Features Mediating Fibrin Selectivity of Vampire Bat Plasminogen Activators

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Species-specific urokinase receptor ligands reduce glioma growth and increase survival primarily by an antiangiogenesis mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Transforming growth factor-beta and ischemic brain injury

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Up-regulation of a serine protease inhibitor in astrocytes mediates the neuroprotective activity of transforming growth factor beta1.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Tissue plasminogen activator controls multiple forms of synaptic plasticity and memory

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Reduction of excitotoxicity and associated leukocyte recruitment by a broad-spectrum matrix metalloproteinase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Physiological consequences of loss of plasminogen activator gene function in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Tissue plasminogen activator is required for corticostriatal long-term potentiation.

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https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Zinc and brain injury

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Neuroserpin, a neuroprotective factor in focal ischemic stroke.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Familial dementia caused by polymerization of mutant neuroserpin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Generation and characterization of urokinase receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

The fibrinolysis system: regulation of activity and physiologic functions of its main components

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Smad3-dependent induction of plasminogen activator inhibitor-1 in astrocytes mediates neuroprotective activity of transforming growth factor-beta 1 against NMDA-induced necrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Prion protein stimulates tissue-type plasminogen activator-mediated plasmin generation via a lysine-binding site on kringle 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Binding of disease-associated prion protein to plasminogen.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

A different form of long-lasting potentiation revealed in tissue plasminogen activator mutant mice.

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https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Tissue plasminogen activator mRNA expression in granule neurons coincides with their migration in the developing cerebellum

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Transforming growth factor alpha-induced expression of type 1 plasminogen activator inhibitor in astrocytes rescues neurons from excitotoxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Characterization of ameboid microglia isolated from developing mammalian brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Binding of the NG2 proteoglycan to kringle domains modulates the functional properties of angiostatin and plasmin(ogen).

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Membrane depolarization induces calcium-dependent secretion of tissue plasminogen activator.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Selective behaviors altered in plasminogen-deficient mice are reconstituted with intracerebroventricular injection of plasminogen.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

DRL performance in mice with deletion of tPA, uPA or PAI-1 genes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Evidence for disrupted NMDA receptor function in tissue plasminogen activator knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Nonproteolytic neuroprotection by human recombinant tissue plasminogen activator

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Plasminogen activator inhibitor-1 represses integrin- and vitronectin-mediated cell migration independently of its function as an inhibitor of plasminogen activation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

The fate of the prion protein in the prion/plasminogen complex

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

The plasminogen activator family from the salivary gland of the vampire bat Desmodus rotundus: cloning and expression

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Microglia: a sensor for pathological events in the CNS

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Proteases in brain tumour progression

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Catching up on schizophrenia: natural history and neurobiology

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Vampire bat salivary plasminogen activator (desmoteplase): a unique fibrinolytic enzyme that does not promote neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Gene targeting in hemostasis. Alpha2-antiplasmin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Excitatory amino acids as a final common pathway for neurologic disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Urokinase induces receptor mediated brain tumor cell migration and invasion.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Impaired explorative behavior and neophobia in genetically modified mice lacking or overexpressing the extracellular serine protease inhibitor neuroserpin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Progressive neuronal and motor dysfunction in mice overexpressing the serine protease inhibitor protease nexin-1 in postmitotic neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Overexpression of urokinase-type plasminogen activator in transgenic mice is correlated with impaired learning

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

The Possible Role of Tissue-Type Plasminogen Activator (tPA) and tPA Blockers in the Pathogenesis and Treatment of Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Transgenic mice overexpressing urokinase-type plasminogen activator in the brain exhibit reduced food consumption, body weight and size, and increased longevity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Modulation of invasive properties of human glioblastoma cells stably expressing amino-terminal fragment of urokinase-type plasminogen activator.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

In vitro inhibition of human glioblastoma cell line invasiveness by antisense uPA receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Proteolysis and invasiveness of brain tumors: role of urokinase-type plasminogen activator receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Tissue plasminogen activator mediates reverse occlusion plasticity in visual cortex.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Activity-dependent formation of perforated synapses in cultured hippocampal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Rapid, specific and active site-catalyzed effect of tissue-plasminogen activator on hippocampus-dependent learning in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Effects of Disruption of The Plasminogen Gene on Thrombosis, Growth, and Health in Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Role of plasminogen activator-plasmin system in tumor angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Detection of glia-derived nexin in the olfactory system of the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Urokinase-type plasminogen activator (uPA) and its receptor (uPAR): development of antagonists of uPA/uPAR interaction and their effects in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Evidence for impairment of behavioural inhibition in performance of operant tasks in tPA-/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Targeting the over-expressed urokinase-type plasminogen activator receptor on glioblastoma multiforme

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Expression of the proteolytic factors, tPA and uPA, PAI-1 and VEGF during malignant glioma progression.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Extracellular proteolysis in the adult murine brain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Absence of tissue plasminogen activator gene or activity impairs mouse cerebellar motor learning.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Neuronal migration is retarded in mice lacking the tissue plasminogen activator gene

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Neuronal extracellular proteases facilitate cell migration, axonal growth, and pathfinding

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Tissue plasminogen activator induction in Purkinje neurons after cerebellar motor learning.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Cell Type-Specific Roles for Tissue Plasminogen Activator Released by Neurons or Microglia after Excitotoxic Injury

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Tissue plasminogen activator mediates microglial activation via its finger domain through annexin II.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Modulation of zinc toxicity by tissue plasminogen activator.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Plasminogen activator inhibitor-1 contains a cryptic high affinity binding site for the low density lipoprotein receptor-related protein

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Novel aspects and new roles for the serine protease plasmin.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Neuroserpin mutation S52R causes neuroserpin accumulation in neurons and is associated with progressive myoclonus epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Fibrin selectivity of the isolated protease domains of tissue-type and vampire bat salivary gland plasminogen activators.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

The plasmin system is induced by and degrades amyloid-beta aggregates

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

The plasminogen activator/plasmin system

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Localization of tissue plasminogen activator mRNA in adult rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

The molecular basis for anti-proteolytic and non-proteolytic functions of plasminogen activator inhibitor type-1: roles of the reactive centre loop, the shutter region, the flexible joint region and the small serpin fragment

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Plasminogen activator inhibitor-1 is a major stress-regulated gene: implications for stress-induced thrombosis in aged individuals.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Neuroserpin: a selective inhibitor of tissue-type plasminogen activator in the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Expression and significance of urokinase type plasminogen activator gene in human brain gliomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Adjuvant treatment with neuroserpin increases the therapeutic window for tissue-type plasminogen activator administration in a rat model of embolic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Transforming growth factor-beta 1 increases bad phosphorylation and protects neurons against damage.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

Transforming growth factor-beta1 as a regulator of the serpins/t-PA axis in cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2966005-X

7 January 2021

10.1016/S0070-2153(05)66005-X

Identifiers

DOI

1 reference

12 August 2017

1 reference

PubMed ID

15825268