Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. (Q36098242)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942707%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential (English)

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9 January 2020

1 reference

3

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9 January 2020

author name string

Piu Wong

1

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9 January 2020

Masayuki Iwasaki

2

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9 January 2020

Chi Wai Eric So

4

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9 January 2020

Michael L Cleary

5

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9 January 2020

publication date

17 October 2007

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9 January 2020

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9 January 2020

volume

21

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9 January 2020

issue

21

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9 January 2020

page(s)

2762-2774

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HOX deregulation in acute myeloid leukemia

9 January 2020

cites work

1 reference

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The role of HOX genes in malignant myeloid disease

2 October 2017

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Leukemic stem cells: where do they come from?

2 October 2017

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Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia.

2 October 2017

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Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

2 October 2017

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Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression

2 October 2017

1 reference

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The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis

2 October 2017

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Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells.

2 October 2017

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Global and Hox-specific roles for the MLL1 methyltransferase

2 October 2017

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Hox regulation of normal and leukemic hematopoietic stem cells.

2 October 2017

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hDOT1L links histone methylation to leukemogenesis

2 October 2017

1 reference

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Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus

2 October 2017

1 reference

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MLL is fused to EB1 (MAPRE1), which encodes a microtubule-associated protein, in a patient with acute lymphoblastic leukemia

2 October 2017

1 reference

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Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.

2 October 2017

1 reference

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Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs

2 October 2017

1 reference

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Pbx3 deficiency results in central hypoventilation

2 October 2017

1 reference

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Cre-lox-regulated conditional RNA interference from transgenes

2 October 2017

1 reference

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The TALE homeodomain protein Pbx2 is not essential for development and long-term survival

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Expression of HOX genes in acute leukemia cell lines with and without MLL translocations

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Hematopoietic, angiogenic and eye defects in Meis1 mutant animals

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

A novel infant acute lymphoblastic leukemia cell line with MLL-AF5q31 fusion transcript

2 October 2017

1 reference

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Common mechanism for oncogenic activation of MLL by forkhead family proteins

2 October 2017

1 reference

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2 October 2017

1 reference

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MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation

2 October 2017

1 reference

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The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Development of a model for evaluating the interaction between human pre-B acute lymphoblastic leukemic cells and the bone marrow stromal cell microenvironment

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Functional and regulatory interactions between Hox and extradenticle genes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

NovelMLL-CBP fusion transcript in therapy-related chronic myelomonocytic leukemia with a t(11;16) (q23;p13) chromosome translocation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

The specificity of homeotic gene function

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Altered Hox expression and segmental identity in Mll-mutant mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Gene expression profiling of pediatric acute myelogenous leukemia

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

XMeis3 protein activity is required for proper hindbrain patterning in Xenopus laevis embryos

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Genetic evidence for the transcriptional-activating function of Homothorax during adult fly development.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045130

Frequent co-expression of HoxA9 and Meis1 genes in infant acute lymphoblastic leukaemia with MLL rearrangement

23 September 2018

1 reference

12 December 2020

Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny

1 reference

12 December 2020

Interaction of MLL amino terminal sequences with menin is required for transformation

1 reference

12 December 2020

Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia

1 reference

12 December 2020

The proportion of clonal divisions varies in different hematologic malignancies. The United Kingdom Cancer Cytogenetics Group (UKCCG) [corrected]

1 reference

12 December 2020

Identifiers

DOI

10.1101/GAD.1602107

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942707%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942707%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

17942707

1 reference