Impairment of osteoblast differentiation due to proliferation-independent telomere dysfunction in mouse models of accelerated aging (Q36103691)

12 August 2017

Impairment of osteoblast differentiation due to proliferation-independent telomere dysfunction in mouse models of accelerated aging (English)

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12 August 2017

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Haitao Wang

1

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12 August 2017

Qijun Chen

2

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12 August 2017

Seoung-Hoon Lee

3

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12 August 2017

Yongwon Choi

4

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12 August 2017

Frederick Brad Johnson

5

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12 August 2017

Robert J Pignolo

6

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12 August 2017

11 June 2012

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12 August 2017

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12 August 2017

11

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12 August 2017

4

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12 August 2017

704-713

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Senescence-associated intrinsic mechanisms of osteoblast dysfunctions.

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Extrinsic mechanisms involved in age-related defective bone formation.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Donor age and cell passage affects differentiation potential of murine bone marrow-derived stem cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Dual roles of telomere dysfunction in initiation and suppression of tumorigenesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

The tec family tyrosine kinase Btk Regulates RANKL-induced osteoclast maturation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

The role of DNA damage repair in aging of adult stem cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Cellular senescence: when bad things happen to good cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Sustained stromal stem cell self-renewal and osteoblastic differentiation during aging

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Dyskeratosis congenita -- a disease of dysfunctional telomere maintenance

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Shared phenotypes among segmental progeroid syndromes suggest underlying pathways of aging

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Telomerase mediates vascular endothelial growth factor-dependent responsiveness in a rat model of hind limb ischemia.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Phosphorylation of H2AX at short telomeres in T cells and fibroblasts

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Involvement of telomere dysfunction in the induction of genomic instability by radiation in scid mouse cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Modeling pO(2) distributions in the bone marrow hematopoietic compartment. II. Modified Kroghian models

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Telomerase expression restores dermal integrity to in vitro-aged fibroblasts in a reconstituted skin model.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Nuclear structure in normal and Bloom syndrome cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Tumor spectrum analysis in p53-mutant mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400025

A theoretical simulation of hematopoietic stem cells during oxygen fluctuations: prediction of bone marrow responses during hemorrhagic shock.

2 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00838.X

Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00838.X

Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00838.X

Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00838.X

Reconstituting telomerase activity using the telomerase catalytic subunit prevents the telomere shorting and replicative senescence in human osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00838.X

Hypoxia affects mesenchymal stromal cell osteogenic differentiation and angiogenic factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00838.X

Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan

21 January 2018

1 reference

12 December 2020

Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths

1 reference

12 December 2020

p21(WAF1/CIP1) acts as a brake in osteoblast differentiation

1 reference

12 December 2020

Kinetics of hemopoietic stem cells in a hypoxic culture

1 reference

12 December 2020

Positional mapping of genes by chromosome blotting and chromosome fragmentation

1 reference

12 December 2020

10.1111/J.1474-9726.2012.00838.X

Identifiers

DOI

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

22621437

1 reference