Cannabinoid-based drugs as anti-inflammatory therapeutics (Q36111923)

12 August 2017

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title

Cannabinoid-based drugs as anti-inflammatory therapeutics (English)

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12 August 2017

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Thomas W Klein

1

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12 August 2017

1 May 2005

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Nature Reviews Immunology

12 August 2017

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12 August 2017

5

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12 August 2017

400-411

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12 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nri1602

12 August 2017

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Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance

31 March 2020

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Isolation and structure of a brain constituent that binds to the cannabinoid receptor

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Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

31 March 2020

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Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

31 March 2020

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2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor

31 March 2020

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Structure of a cannabinoid receptor and functional expression of the cloned cDNA

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Molecular characterization of a peripheral receptor for cannabinoids

31 March 2020

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Cannabinoid receptors and immunity.

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Cannabinoid receptors and the regulation of immune response

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Modulation of transmitter release via presynaptic cannabinoid receptors

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Toll-like receptor signalling

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Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages

31 March 2020

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Endocannabinoid degradation, endotoxic shock and inflammation.

31 March 2020

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Presence and regulation of the endocannabinoid system in human dendritic cells

31 March 2020

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Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes

31 March 2020

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Inflammation in neurodegenerative disease--a double-edged sword

31 March 2020

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Chemokines: multiple levels of leukocyte migration control.

31 March 2020

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2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces the migration of EoL-1 human eosinophilic leukemia cells and human peripheral blood eosinophils

31 March 2020

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Distinct expression profiles of the peripheral cannabinoid receptor in lymphoid tissues depending on receptor activation status

31 March 2020

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The endogenous cannabinoid 2-arachidonoyl glycerol as in vivo chemoattractant for dendritic cells and adjuvant for Th1 response to a soluble protein

31 March 2020

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The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner

31 March 2020

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Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain

31 March 2020

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Differential expression of cannabinoid CB(2) receptor mRNA in mouse immune cell subpopulations and following B cell stimulation

31 March 2020

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Anti-CD40, anti-CD3, and IL-2 stimulation induce contrasting changes in CB1 mRNA expression in mouse splenocytes

31 March 2020

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Autocrine and paracrine regulation of lymphocyte CB2 receptor expression by TGF-beta

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delta 9-Tetrahydrocannabinol, cytokines, and immunity to Legionella pneumophila

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Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation

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Nonpsychotropic cannabinoid receptors regulate microglial cell migration.

31 March 2020

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The immunological synapse.

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In vitro and in vivo suppressive effects of delta-9-tetrahydrocannabinol on interferon production by murine spleen cells.

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Delta 9-tetrahydrocannabinol decreases alpha/beta interferon response to herpes simplex virus type 2 in the B6C3F1 mouse.

31 March 2020

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The cannabinoid system and cytokine network

31 March 2020

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Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant

31 March 2020

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The role of excitotoxicity in neurodegenerative disease: implications for therapy

31 March 2020

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Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN

31 March 2020

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Marijuana and cocaine impair alveolar macrophage function and cytokine production

31 March 2020

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Modulation of cytokine responses in Corynebacterium parvum-primed endotoxemic mice by centrally administered cannabinoid ligands

31 March 2020

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Genomic and functional changes induced by the activation of the peripheral cannabinoid receptor CB2 in the promyelocytic cells HL-60. Possible involvement of the CB2 receptor in cell differentiation

31 March 2020

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2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells

31 March 2020

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Cannabinoids inhibit neurodegeneration in models of multiple sclerosis

31 March 2020

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Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model.

31 March 2020

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IFN-gamma affects homing of diabetogenic T cells

31 March 2020

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Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease

31 March 2020

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Delta 9-tetrahydrocannabinol treatment suppresses immunity and early IFN-gamma, IL-12, and IL-12 receptor beta 2 responses to Legionella pneumophila infection

31 March 2020

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Regulation of interleukin-12 production by G-protein-coupled receptors

31 March 2020

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Delta-9-tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway

31 March 2020

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Cornerstone of peripheral tolerance: naturally occurring CD4+CD25+ regulatory T cells

31 March 2020

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Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells

31 March 2020

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Delta 9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells

31 March 2020

1 reference

Modulation of the Immune System in Cannabis Users

31 March 2020

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Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R+WIN55,212

31 March 2020

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Therapeutic action of cannabinoids in a murine model of multiple sclerosis.

31 March 2020

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A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation

31 March 2020

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Cannabinoid receptors and T helper cells

31 March 2020

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31 March 2020

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Cannabinoid physiology and pharmacology: 30 years of progress.

31 March 2020

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Cannabinoids control spasticity and tremor in a multiple sclerosis model

31 March 2020

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The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation.

31 March 2020

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Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation

31 March 2020

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A new strategy to block tumor growth by inhibiting endocannabinoid inactivation

31 March 2020

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Delta 9-tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis

31 March 2020

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Suppression of experimental autoimmune encephalomyelitis by cannabinoids

31 March 2020

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The THC-induced suppression of Th1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2.

31 March 2020

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A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes

31 March 2020

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Control of pain initiation by endogenous cannabinoids.

31 March 2020

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Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS

31 March 2020

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Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial

31 March 2020

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Endocannabinoids control spasticity in a multiple sclerosis model

31 March 2020

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Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial

31 March 2020

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Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study

31 March 2020

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Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients

31 March 2020

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An endogenous cannabinoid (2-AG) is neuroprotective after brain injury

31 March 2020

1 reference

Dexanabinol (HU-211) in the treatment of severe closed head injury: a randomized, placebo-controlled, phase II clinical trial

31 March 2020

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Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia.

31 March 2020

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Functional assessment of neuronal cannabinoid receptors in the muscular layers of human ileum and colon

31 March 2020

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Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation

31 March 2020

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Endocannabinoids as physiological regulators of colonic propulsion in mice

31 March 2020

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Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats

31 March 2020

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The endogenous cannabinoid system protects against colonic inflammation

31 March 2020

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Suppression of human monocyte interleukin-1beta production by ajulemic acid, a nonpsychoactive cannabinoid

31 March 2020

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Pain reduction and lack of psychotropic effects with ajulemic acid: comment on the article by Sumariwalla et al.

31 March 2020

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The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis

31 March 2020

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Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells

31 March 2020

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A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis

31 March 2020

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Simultaneous measurement of anandamide and 2-arachidonoylglycerol by polymyxin B-selective adsorption and subsequent high-performance liquid chromatography analysis: increase in endogenous cannabinoids in the sera of patients with endotoxic shock

31 March 2020

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Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases.

31 March 2020

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Evidence for a new G protein-coupled cannabinoid receptor in mouse brain.

31 March 2020

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Membrane cholesterol but not putative receptors mediates anandamide-induced hepatocyte apoptosis

31 March 2020

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Clustering of MHC-peptide complexes prior to their engagement in the immunological synapse: lipid raft and tetraspan microdomains

31 March 2020

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Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids.

31 March 2020

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Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide

31 March 2020

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Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells

31 March 2020

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inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NRI1602

1 reference

PubMed ID

15864274

Dimensions Publication ID

12 August 2017

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1 reference

PubMed ID

15864274