Discovery of histone deacetylase 8 selective inhibitors (Q36111962)

12 August 2017

Discovery of histone deacetylase 8 selective inhibitors (English)

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12 August 2017

5

Stuart L Schreiber

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12 August 2017

Weiping Tang

1

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12 August 2017

Tuoping Luo

series ordinal

2

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12 August 2017

Edward F Greenberg

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3

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12 August 2017

James E Bradner

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4

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12 August 2017

language of work or name

English

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publication date

2 February 2011

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12 August 2017

5

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Bioorganic & Medicinal Chemistry Letters

inferred from page(s)

published in

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12 August 2017

21

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12 August 2017

9

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12 August 2017

2601-2605

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Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A

12 August 2017

1 reference

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On the inhibition of histone deacetylase 8

2 October 2017

1 reference

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Chemical phylogenetics of histone deacetylases

2 October 2017

1 reference

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Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum

2 October 2017

1 reference

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Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.

2 October 2017

1 reference

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Isoform-selective histone deacetylase inhibitors

2 October 2017

1 reference

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A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum

2 October 2017

1 reference

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A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

2 October 2017

1 reference

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Histone deacetylase inhibitors: from bench to clinic

2 October 2017

1 reference

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Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors

2 October 2017

1 reference

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Small molecules: the missing link in the central dogma

2 October 2017

1 reference

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Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

2 October 2017

1 reference

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Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

The nucleosome: from genomic organization to genomic regulation

2 October 2017

1 reference

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From discovery to the coming generation of histone deacetylase inhibitors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays

2 October 2017

1 reference

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From Knowing to Controlling: A Path from Genomics to Drugs Using Small Molecule Probes

2 October 2017

1 reference

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Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

2 October 2017

1 reference

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Signaling network model of chromatin

2 October 2017

1 reference

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In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family

2 October 2017

1 reference

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Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Isolation and characterization of mammalian HDAC10, a novel histone deacetylase

2 October 2017

1 reference

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Cloning and characterization of a histone deacetylase, HDAC9

2 October 2017

1 reference

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Translating the Histone Code

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Split--pool synthesis of 1,3-dioxanes leading to arrayed stock solutions of single compounds sufficient for multiple phenotypic and protein-binding assays

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Deacetylation of p53 modulates its effect on cell growth and apoptosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Acetylation: a regulatory modification to rival phosphorylation?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Three proteins define a class of human histone deacetylases related to yeast Hda1p

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Second generation hybrid polar compounds are potent inducers of transformed cell differentiation.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Microtubules containing acetylated alpha-tubulin in mammalian cells in culture

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Azetidinones as zinc-binding groups to design selective HDAC8 inhibitors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Histone Deacetylase Inhibitors

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Structural Biasing Elements for In-Cell Histone Deacetylase Paralog Selectivity

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Inhibitors of histone deacetylase are potentially effective anticancer agents

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3403710

Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21334896

12 December 2020

inferred from PubMed ID database lookup

Toward selective histone deacetylase inhibitor design: homology modeling, docking studies, and molecular dynamics simulations of human class I histone deacetylases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21334896

12 December 2020

inferred from PubMed ID database lookup

Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21334896

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.BMCL.2011.01.134

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12 August 2017

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12 August 2017

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